Artery Research

Volume 24, Issue C, December 2018, Pages 91 - 92

P47 ABNORMAL FLOW PATTERN IN MARFAN PATIENTS IS RELATED TO AORTIC GEOMETRIC FEATURES: A 4D FLOW MRI STUDY

Authors
Andrea Guala, Gisela Teixido-Tura, Jose Rodriguez-Palomares, Aroa Ruiz-Muñoz, David Garcia-Dorado, Artur Evangelista
Hospital Vall d’Hebron, Department of Cardiology, VHIR, Universitat Autònoma de Barcelona, Barcelona, Spain
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.100How to use a DOI?
Abstract

Introduction: Ascending aorta aneurysm and dissection are the most common cardiovascular complications affecting Marfan syndrome patients (MFS). Recent large increase in life expectancy of MFS driven the growing prevalence of descending aorta (DAo) dilation and dissection. Despite local abnormal vortices in the proximal Dao were related to local dilation, their origins have never been explored. We investigated the link between aortic geometrical characteristics and abnormal flow pattern in the thoracic aorta of MFS.

Methods: Fifty-tree MFS without significant aortic valve disease and forty age-matched healthy volunteers (HV) were prospectively included in 4D flow-MRI study, obtaining flow field and angiography. Spatial distribution of flow (in-plane rotational flow (IRF) and systolic flow reversal ratio (SFRR)) and geometric (diameter, ellipticity and curvature) parameters were investigated.

Results: Compared to HV, MFS presented larger aortic diameters only in the proximal AAo (p < 0.001) and DAo (p = 0.028). Increased ellipticity and a more distal location for the peak of aortic curvature were evident, even in the absence of dilation. Through most of the thoracic aorta, IRF was substantially lower in MFS, while SFRR was larger. Interestingly, non-dilated MFS had decreased IRF in the thoracic aorta compared to HV, although SFRR was not increased. Statistically-significant bivariate relations were found between arch IRF and arch ellipticity (R = -0.34) and proximal DAo peak curvature (R = -0.35). Local diameter was negatively correlated with local IRF (R = -0.3) and positively correlated to local SFRR (R = 0.605).

Conclusions: MFS presented altered ellipticity and curvature distribution, which are related to abnormal flow patterns even in the absence of dilation.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
91 - 92
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.100How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Andrea Guala
AU  - Gisela Teixido-Tura
AU  - Jose Rodriguez-Palomares
AU  - Aroa Ruiz-Muñoz
AU  - David Garcia-Dorado
AU  - Artur Evangelista
PY  - 2018
DA  - 2018/12/04
TI  - P47 ABNORMAL FLOW PATTERN IN MARFAN PATIENTS IS RELATED TO AORTIC GEOMETRIC FEATURES: A 4D FLOW MRI STUDY
JO  - Artery Research
SP  - 91
EP  - 92
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.100
DO  - 10.1016/j.artres.2018.10.100
ID  - Guala2018
ER  -