Artery Research

Volume 24, Issue C, December 2018, Pages 86 - 86

P22 THE ROLE OF RENAL DYSFUNCTION ON TARGET ORGAN DAMAGE AND CARDIOVASCULAR RISK IN HYPERTENSIVES

Authors
Eirini Solomou1, Dimitrios Terentes Printzios2, Charalampos Vlachopoulos2, N. Ioakimidis2, K. Aznaouridis2, I. Koutagiar2, V. Gardikioti2, E. Sigala2, D. Tousoulis2
1First Academic Cardiology Clinic, Hippokration General Hospital, Athens, Greece
21st Cardiology Department, Athens Medical School, Hippokration General Hospital, Athens, Greece
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.075How to use a DOI?
Abstract

Purpose/Background/Objective: Hypertension is associated with increased left ventricular (LV) hypertrophy, aortic stiffness and renal dysfunction, which are all predictors of cardiovascular risk. We investigated the effect of renal dysfunction on LV mass and aortic stiffness in hypertensives.

Methods: We enrolled 1223 consecutive hypertensives (mean age 53.0 ± 11.6 years, 726 males). We estimated the glomerular filtration ratio (GFR) using the MDRD formula. We classified our population as hypertensives with moderate to severe renal dysfunction (GFR ≥ 60 ml/min/1.73 m2, n = 1091). LV mass index (LVMI) was assessed echocardiographically and calculated using the Devereux formula. Aortic stiffness and wave reflections were assessed with pulse wave velocity (PWV) and augmentation index (AIx), respectively. Ten-year cardiovascular risk was estimated with Framingham Risk score.

Results: After adjustment for age, gender, mean blood pressure, body-mass index, diabetes mellitus, low-density lipoprotein and C-reactive protein hypertensives with GFR < 60 ml/min/1.73 m2 compared to hypertensives with GFR ≥ 60 ml/min/1.73 m2 had higher PWV levels (8.86 m/s vs. 7.92 m/s, p = 0.014), higher LVMI (119.5 g/m2 vs. 114.9 g/m2, p = 0.012) and higher AIx (31.1% vs. 27.4%, p = 0.05). On the contrary, hypertensives with GFR < 60 ml/min/1.73 m2 had similar 10-year cardiovascular risk compared to hypertensives with GFR ≥ 60 ml/min/1.73 m2 (17.3% vs. 13.0%, p = 0.323).

Conclusions: Renal dysfunction is associated with LVMI and aortic stiffness. Hypertensives with moderate to severe renal dysfunction despite having similar 10-year cardiovascular risk with hypertensives with normal renal function or mild renal dysfunction, demonstrate higher aortic stiffness and LV mass, implying a possible underestimation of risk by Framingham.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
86 - 86
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.075How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Eirini Solomou
AU  - Dimitrios Terentes Printzios
AU  - Charalampos Vlachopoulos
AU  - N. Ioakimidis
AU  - K. Aznaouridis
AU  - I. Koutagiar
AU  - V. Gardikioti
AU  - E. Sigala
AU  - D. Tousoulis
PY  - 2018
DA  - 2018/12/04
TI  - P22 THE ROLE OF RENAL DYSFUNCTION ON TARGET ORGAN DAMAGE AND CARDIOVASCULAR RISK IN HYPERTENSIVES
JO  - Artery Research
SP  - 86
EP  - 86
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.075
DO  - 10.1016/j.artres.2018.10.075
ID  - Solomou2018
ER  -