Artery Research

Volume 24, Issue C, December 2018, Pages 103 - 103

P86 BLUNTED CEREBRAL MICROCIRCULATION OXYGENATION DURING EXERCISE IN NEWLY DIAGNOSED HYPERTENSIVE PATIENTS: LINKS WITH INDICES OF MACROCIRCULATION AND ARTERIAL STIFFNESS

Authors
Areti Triantafyllou1, Konstantina Dipla2, Nikolaos Koletsos1, Alexandros-Savvas Zafeiridis1, Stauros Papadopoulos2, Iris Grigoriadou2, Eugenia Gkaliagkousi1, Andreas Zafeiridis2, Stella Douma1
13rd Dep. of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
2Dep. of Physical Education and Sports Science at Serres, Aristotle University of Thessaloniki, Serres, Greece
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.139How to use a DOI?
Abstract

Purpose/Background/Objective: Hypertension has been considered as one of the most common modifiable risk factors for stroke and cognitive impairment. Decreased cerebral perfusion and oxygenation, as a result of capillary rarefaction and microvascular impairment of brain vessels, have been suggested as potentials underlying mechanisms. However, there is no study investigating whether these parameters are present in newly-diagnosed hypertensive patients (HP), without any co-morbidities. Thus, we examined (i) whether functional activation of the human cerebral cortex during handgrip exercise is altered in newly diagnosed HP and (ii) whether cerebral oxygenation correlates with different markers of arterial stiffness.

Methods: Forty-five newly diagnosed HP and 36 normotensives underwent an exercise protocol, consisting of a 3-min-rest, a 3-min-handgrip exercise (30% MVC), and a 3-min-recovery. Continuous-near-infrared-spectroscopy (NIRS) was used to monitor changes in cerebral-[O2Hb]. IMT, Augmentation Index, Central-BP and PWV (Sphygmocor) were assessed.

Results: No significant differences were detected between groups in age, BMI, sex, MVC and force maintained during handgrip. During handgrip, cerebral[O2Hb] increased in both groups; however, hypertensive patientsexhibited a significantly lower average response than normotensives [1.6(1.1–2.7) vs. 2.4(1.4–3.2)μM], respectively, p < 0.05 and a lower peak [O2Hb] [4.2(3.3–6.2) vs. 5.9(4.3–9.2), p < 0.01]. Significant negative correlations were found between cerebral-[O2Hb] and aortic BP, AI, and PWV.

Conclusions: Hypertensive patients exhibited a blunted cerebral [O2Hb] response during handgrip exercise compared to their normotensive counterparts. This blunted increase in cerebral oxygenation during exercise was present in patients with recent diagnosis of hypertension and without evident TOD and correlated with macrovascular stiffening, indicating a cross-talk between micro- and microcirculation.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
24 - C
Pages
103 - 103
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.139How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Areti Triantafyllou
AU  - Konstantina Dipla
AU  - Nikolaos Koletsos
AU  - Alexandros-Savvas Zafeiridis
AU  - Stauros Papadopoulos
AU  - Iris Grigoriadou
AU  - Eugenia Gkaliagkousi
AU  - Andreas Zafeiridis
AU  - Stella Douma
PY  - 2018
DA  - 2018/12/04
TI  - P86 BLUNTED CEREBRAL MICROCIRCULATION OXYGENATION DURING EXERCISE IN NEWLY DIAGNOSED HYPERTENSIVE PATIENTS: LINKS WITH INDICES OF MACROCIRCULATION AND ARTERIAL STIFFNESS
JO  - Artery Research
SP  - 103
EP  - 103
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.139
DO  - 10.1016/j.artres.2018.10.139
ID  - Triantafyllou2018
ER  -