Artery Research

Volume 24, Issue C, December 2018, Pages 47 - 61

Interaction of the blood components and plaque in a stenotic coronary artery

Authors
Alireza Karimia, *, Reza Razaghib
aDepartment of Mechanical Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan
bBasir Eye Health Research Center, Tehran Iran
*Corresponding author. Fax.: +81 92 802 0001. E-mail addresses: karimi@kyudai.jp (A. Karimi), rrazaghi@tabrizu.ac.ir (R. Razaghi).
Corresponding Author
Alireza Karimi
Received 29 September 2018, Accepted 5 November 2018, Available Online 19 November 2018.
DOI
https://doi.org/10.1016/j.artres.2018.11.002How to use a DOI?
Keywords
Coronary artery; Plaque; Red blood cell; White blood cell; Plasma; Finite element model
Abstract

Background: So far, in the stress calculation of the plaques, the blood has been simulated as a single component, and the role of the mechanical interaction between the red blood cells (RBCs), white blood cells (WBCs), and plasma with that of the plaque has been neglected. This study was aimed at proposing an interactive method based on smoothed particle hydrodynamics (SPH), a fully mesh-free particle approach, to simulate the blood as a fluid with free surfaces, including the RBC, WBC, and plasma, to determine the vulnerable plaque on a basis of the induced stresses.

Materials and methods: A three-dimensional (3D) finite element (FE) model of the atherosclerotic coronary artery was established according to the CT/MRI data of a patient. SPH method was employed toward our blood particles simulation by deriving the force density fields directly from the Navier-Stokes equation and incorporated into the FE equations. The stress in the plaque, necrotic core (NC), and arterial layers were then calculated and compared.

Results: The results revealed the highest stress in the adventitia layer while the lowest one was observed in the media. Regarding the blood components, the plasma experienced the highest stress in the downstream while the RBCs and WBCs in the location where in the direct contact with the plaque tissue.

Conclusions: The results have implications for understanding the roles of RBCs, WBCs, and plasma in inducing the stresses and deformations in the plaques and arterial layers to provide plaque vulnerability prediction information for the medical and biomechanical experts.

Copyright
© 2018 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
47 - 61
Publication Date
2018/11/19
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.1016/j.artres.2018.11.002How to use a DOI?
Copyright
© 2018 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Alireza Karimi
AU  - Reza Razaghi
PY  - 2018
DA  - 2018/11/19
TI  - Interaction of the blood components and plaque in a stenotic coronary artery
JO  - Artery Research
SP  - 47
EP  - 61
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.11.002
DO  - https://doi.org/10.1016/j.artres.2018.11.002
ID  - Karimi2018
ER  -