Artery Research

Volume 24, Issue C, December 2018, Pages 107 - 107

P98 AGE AND GENDER DIFFERENCES IN VARIABILITY OF WAVE REFLECTIONS OVER 24 HOURS: THE INTERNATIONAL 24-HOUR AMBULATORY AORTIC BLOOD PRESSURE CONSORTIUM (I24ABC)

Authors
Thomas Weber1, Siegfired Wasserheurer2, James Sharman3, Cristina Giannatasio4, Piotr Jankowski5, Yan Li6, Alessandro Maloberti4, Barry Mcdonnell7, Carmel McEniery8, Maria Lorenza Muisan9, Janos Nemcsik10, Anna Paini9, Enrique Rodilla11, Ian Wilkinson12, Robert Zweiker13, Athanase Protogerou14
1Cardiology Department, Klinikum Wels-Grieskirchen, Wels, Austria
2Austrian Institute of Technology, Vienna, Austria
3Menzies Institute for Medical Research, University of Tasmania, Australia
4University Milano-Bicocca, Milan, Italy
5Jagellonian University Krakow, Krakow, Poland
6Shanghai Institute of Hypertension, Shanghai Jiaotong University School of Medicine, Shanghai, China
7Cardiff Metropolitan University, Cardiff, UK
8Cambridge University, Cambridge, UK
9Università di Brescia, Italy
10Semmelweis University Budapest, Hungary
11Valencia (Hospital de Sagunto) Universidad CEU Cardenal Herrera, Spain
12Cambridge University, UK
13Cardiology Department, Medical University Graz, Austria
14Department of Pathophysiology Medical School National and Kapodistrian University of Athens, Athens, Greece
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.151How to use a DOI?
Abstract

Background: Wave reflection parameters predict cardiovascular events, but 24-hour profiles in large samples of healthy adults are unknown.

Methods: In 1645 individuals free from antihypertensive drugs from 11 centers in Europe and Asia, 24-hour blood pressure monitoring with a validated oscillometric brachial cuff (Mobilograph, I.E.M., Stolberg; Germany) was performed. Brachial waveforms were acquired and processed with ARCSolver algorithms to derive information relating to wave reflections using pulse waveform analysis (heart-rate corrected augmentation index-AIx75, augmentation pressure-AP) and wave separation analysis (backward wave amplitude-Pb, reflection magnitude-RM). Nighttime/daytime difference (N/D) was nighttime (01.00–06.00) minus daytime (09.00–21.00) values/daytime values. Participants were categorized as young (13–39 years; male/female: 219/112), middle-aged (40–66 years; male/female: 545/553), and old (67–104 years; male/female: 86/130).

Results: 24-hour measures of wave reflections increased with increasing age and were significantly lower in men compared to women (AIx75: 18.3 vs 28.0 %, AP: 10.1 vs 14.9 mm Hg, Pb: 18.9 vs 20.0 mm Hg, RM: 63.0 vs 66.2). AIx75 was higher during daytime compared to nighttime (23.3 vs 21.3%), but only in young and middle-aged participants. For all participants, AP (11.6 vs 14.5 mm Hg), Pb (18.5 vs 21.7 mm Hg), and RM (62.9 vs 68.8) were higher during nighttime compared to daytime. N/D varied with age and was more pronounced in younger individuals.

Conclusion: 24-hour variability of wave reflection parameters differs according to age and gender. In future, this information could be useful for tailoring individual cardiovascular risk management.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
24 - C
Pages
107 - 107
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.151How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Thomas Weber
AU  - Siegfired Wasserheurer
AU  - James Sharman
AU  - Cristina Giannatasio
AU  - Piotr Jankowski
AU  - Yan Li
AU  - Alessandro Maloberti
AU  - Barry Mcdonnell
AU  - Carmel McEniery
AU  - Maria Lorenza Muisan
AU  - Janos Nemcsik
AU  - Anna Paini
AU  - Enrique Rodilla
AU  - Ian Wilkinson
AU  - Robert Zweiker
AU  - Athanase Protogerou
PY  - 2018
DA  - 2018/12/04
TI  - P98 AGE AND GENDER DIFFERENCES IN VARIABILITY OF WAVE REFLECTIONS OVER 24 HOURS: THE INTERNATIONAL 24-HOUR AMBULATORY AORTIC BLOOD PRESSURE CONSORTIUM (I24ABC)
JO  - Artery Research
SP  - 107
EP  - 107
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.151
DO  - 10.1016/j.artres.2018.10.151
ID  - Weber2018
ER  -