Artery Research

Volume 24, Issue C, December 2018, Pages 122 - 122

P147 ASSOCIATIONS BETWEEN RESERVOIR PRESSURE PARAMETERS AND KIDNEY FUNCTION ARE DEPENDENT ON THE ARTERIAL MEASUREMENT SITE

Authors
Matthew Armstrong1, Dean Picone1, Martin Schultz1, James Sharman1, Nathan Dwyer2, Philip Roberts-Thomson2, Andrew Black2
1Menzies Institute for Medical Research, University of Tasmania, Australia
2Royal Hobart Hospital, Australia
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.200How to use a DOI?
Abstract

Introduction: Reservoir pressure parameters derived from pressure waveforms captured at various arterial sites predict adverse kidney function independently of conventional cuff blood pressure (BP). However, there has never been an analysis directly comparing if associations with kidney function may differ depending on arterial site of measurement, which was the aim of this study.

Methods: Intra-arterial BP waveforms were measured via fluid filled catheter at the ascending aorta, brachial and radial arteries in 172 people undergoing coronary angiography (aged 60 ± 13 years, 67% male). Customised Matlab software was used to derive reservoir pressure and associated parameters of excess pressure, diastolic and systolic rate constants at each arterial site. Kidney function was determined by estimated glomerular filtration rate (eGFR).

Results: Reservoir and excess pressure derived from BP waveforms measured at the aorta were associated with eGFR (r = −0.26, and r = −0.24, p < 0.01, respectively), but not from brachial or radial BP waveforms (r < −0.14, p > 0.07 all). However, diastolic rate constants from BP waveforms at all arterial sites were significantly associated with eGFR. These associations remained following adjustment for aortic systolic BP, heart rate, sex, and body mass index (β = −0.37, p = 0.001; β = −0.37, p = 0.003; β = −0.25, p = 0.02 respectively). Systolic rate constants were not significantly associated with eGFR at any arterial site.

Conclusion: Associations between reservoir pressure parameters and kidney function are dependent on site of waveform measurement, with exception of the diastolic rate constant, which independently relates to kidney function irrespective of location. This is of clinical relevance since this variable can be derived from non-invasively recorded peripheral BP waveforms.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
122 - 122
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.200How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Matthew Armstrong
AU  - Dean Picone
AU  - Martin Schultz
AU  - James Sharman
AU  - Nathan Dwyer
AU  - Philip Roberts-Thomson
AU  - Andrew Black
PY  - 2018
DA  - 2018/12/04
TI  - P147 ASSOCIATIONS BETWEEN RESERVOIR PRESSURE PARAMETERS AND KIDNEY FUNCTION ARE DEPENDENT ON THE ARTERIAL MEASUREMENT SITE
JO  - Artery Research
SP  - 122
EP  - 122
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.200
DO  - 10.1016/j.artres.2018.10.200
ID  - Armstrong2018
ER  -