Artery Research

Volume 24, Issue C, December 2018, Pages 90 - 91

P43 MASKED HYPERTENSION AND RETINAL VESSEL STRUCTURE AND FUNCTION IN YOUNG HEALTHY ADULTS: THE AFRICAN-PREDICT STUDY

Authors
Nthai Ramoshaba1, Hugo Huisman1, 2, Leandi Lammertyn1, 2, Konstantin Kotliar3, Aletta Schutte1, 2, Wayne Smith1, 2
1Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa
2South African Medical Research Council, Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa
3Department of Biomedical Engineering and Technomathematics, Aachen University of Applied Sciences, Juelich, Germany
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.096How to use a DOI?
Abstract

Background: Masked hypertension (MH) is prevalent in young adults and is associated with similar vascular complications as sustained hypertension, but whether this is already evident in young adults is unclear. We therefore compared retinal vessel calibres and function in response to flicker light induced provocation (FLIP) in young healthy adults stratified by MH status and explored associations between these parameters.

Methods: We used data from the first 566 participants (aged 20–30 years) taking part in the African-PREDICT study. Participants were clinically normotensive (70% valid readings) were measured and MH status determined. The central retinal artery (CRAE) and vein equivalent (CRVE) were calculated from fundus images and retinal vessel dilation responses to FLIP determined.

Results: MH showed a prevalence of 16%. MHs’ had a lower CRAE (155 ± 10 MU vs. 160 ± 12 MU, p = 0.002), but similar CRVE and vessel dilation in response to FLIP when compared to normotensives. The latter findings remained consistent upon adjustment for sex, ethnicity, age and body mass index. Multivariate regression analysis demonstrated an independent association between CRAE and the presence of MH (R2 = 0.07, β = −0.10 (−0.20; −0.01)). No further associations existed between retinal vessel parameters and MH status.

Conclusion: Already at a young age, healthy adults with MH show slight adverse changes in the retinal microvasculature. Considering the prevalence of MH in young adults, and the predictive value of reduced CRAE, our data emphasize the early identification of altered 24 hr blood pressure patterns.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
90 - 91
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.096How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Nthai Ramoshaba
AU  - Hugo Huisman
AU  - Leandi Lammertyn
AU  - Konstantin Kotliar
AU  - Aletta Schutte
AU  - Wayne Smith
PY  - 2018
DA  - 2018/12/04
TI  - P43 MASKED HYPERTENSION AND RETINAL VESSEL STRUCTURE AND FUNCTION IN YOUNG HEALTHY ADULTS: THE AFRICAN-PREDICT STUDY
JO  - Artery Research
SP  - 90
EP  - 91
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.096
DO  - 10.1016/j.artres.2018.10.096
ID  - Ramoshaba2018
ER  -