Artery Research

Volume 24, Issue C, December 2018, Pages 88 - 88

P31 DO TREATMENT INDUCED CHANGES IN ARTERIAL STIFFNESS AFFECT LEFT VENTRICULAR STRUCTURE AND FUNCTION? – A META-ANALYSIS

Authors
Koen van der Waaij1, Maarten Heusinkveld2, Tammo Delhaas2, Abraham Kroon3, Koen Reesink2
1Department of Biomedical Engineering and Internal Medicine, CARIM School for Cardiovascular Diseases, the Netherlands
2Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht, the Netherlands
3Department of Internal Medicine, CARIM School for Cardiovascular Diseases, Maastricht, the Netherlands
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.084How to use a DOI?
Abstract

Background: Vascular research demonstrated that pulse wave velocity (PWV), a measure of arterial stiffness, is inherently blood pressure-dependent. Considering the hypothesised pathophysiological chain of increased arterial stiffness leading to increased blood pressure load with consequent left ventricle hypertrophy (LVH) development, we conducted a systematic review of antihypertensive and lifestyle intervention studies to determine the association between on the one hand changes in arterial stiffness and blood pressure, and on the other hand changes in LV mass (LVM).

Methods: Using PubMed, EMBASE, Cochrane and Web of Science, we identified 23 studies, containing 2573 patients. Studies reported changes in arterial stiffness (assessed by means of PWV), systolic- and diastolic blood pressure (SBP, DBP), and LVM index (LVMI), respectively.

Results: Statistically significant reductions in SBP, PWV and LVMI were reported in 16, 14, and 20 studies, respectively. Pooled analysis of studies showed that the proportion in SBP reduction did not correlate significantly to the proportion in reductions of the other two variables. On the other hand, we found a significant positive correlation (r = 0.58, p = 0.007) between arterial stiffness and LVM regression, expressed as a relevant reduction in LVMI of 6.5 g/m2 per 1.0 m/s reduction in PWV.

Conclusions: Our findings provide evidence that a decrease in arterial stiffness is associated with regression of LVH. To investigate whether there exists a causal relation between LVH due to arterial stiffness increases and in turn blood pressure load increases, future studies should strive for a multiple followup design and use of blood pressure-independent or -corrected stiffness indices.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
88 - 88
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.084How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Koen van der Waaij
AU  - Maarten Heusinkveld
AU  - Tammo Delhaas
AU  - Abraham Kroon
AU  - Koen Reesink
PY  - 2018
DA  - 2018/12/04
TI  - P31 DO TREATMENT INDUCED CHANGES IN ARTERIAL STIFFNESS AFFECT LEFT VENTRICULAR STRUCTURE AND FUNCTION? – A META-ANALYSIS
JO  - Artery Research
SP  - 88
EP  - 88
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.084
DO  - 10.1016/j.artres.2018.10.084
ID  - vanderWaaij2018
ER  -