Artery Research

Volume 24, Issue C, December 2018, Pages 104 - 104

P89 3 HOURS UNINTERRUPTED SITTING INCREASES CEREBROVASCULAR RESISTANCE AND REDUCES CEREBRAL BLOOD FLOW IN SUBJECTS WITH INCREASED CARDIOVASCULAR RISK

Authors
Yvonne Hartman
Radboud University Medical Center, Nijmegen, the Netherlands
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.142How to use a DOI?
Abstract

Background: Sedentary behavior has deleterious effects on cardiovascular risk. Uninterrupted sitting is associated with an impaired peripheral blood flow and vascular function. However, the relation between cerebrovascular flow and sedentary behavior is currently unknown. Impaired cerebrovascular flow and function are associated with impaired cognitive function and dementia. Therefore, this study investigated the effects of a prolonged sedentary bout on cerebrovascular flow and function.

Methods: 19 participants with increased cardiovascular risk (age > 55 years, BMI 28 kg m−2 or hypertension) underwent a 3 hours uninterrupted sitting intervention. At baseline and after intervention middle cerebral artery blood flow velocity (MCAv) was measured using transcranial Doppler. Cerebrovascular resistance index (CVRi) was expressed as the ratio of MAP:MCAv.

Results: Due to technical difficulties, three participants were excluded from analysis, leaving 16 participants (age = 64 ± 5 years, BMI = 30.5 ± 4.5 kg m−2). MCAv decreased after 3 hours sitting from 50.4 cm−1 s−1 (95% CI 47.0 – 53.7) to 46.9 cm−1 s−1 (95% CI 43.3 – 50.4) cm s−1 (mean difference = 3.5 cm s−1 (95% CI -0.1 – 7.0), P = 0.055). This was accompanied by an increase in CVRi (2.08 ± 0.35 cm−1 s−1 to 2.39 ± 0.56 cm−1 s−1, P = 0.016).

Conclusions: Our results indicate that prolonged sedentary bouts impair cerebrovascular blood flow and stress the importance of frequently interrupting sitting periods in order to maintain adequate cerebral blood flow. Future studies should further investigate the impact of sedentary behaviour in the context of cerebrovascular diseases.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
24 - C
Pages
104 - 104
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.142How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Yvonne Hartman
PY  - 2018
DA  - 2018/12/04
TI  - P89 3 HOURS UNINTERRUPTED SITTING INCREASES CEREBROVASCULAR RESISTANCE AND REDUCES CEREBRAL BLOOD FLOW IN SUBJECTS WITH INCREASED CARDIOVASCULAR RISK
JO  - Artery Research
SP  - 104
EP  - 104
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.142
DO  - 10.1016/j.artres.2018.10.142
ID  - Hartman2018
ER  -