Artery Research

Volume 24, Issue C, December 2018, Pages 105 - 106

P93 RELATIONSHIP BETWEEN AORTIC PULSE WAVE VELOCITY AND MID CEREBRAL ARTERY PULSATILITY INDEX IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE; PILOT DATA FROM THE ARCADE STUDY

Authors
Mahfoudha Al Shezawi1, 2, John Cockcroft2, Maggie Munnery2, laura Watkeys2, Nichola Gale1, Barry McDonnell2
1Cardiff University, Cardiff, Wales, UK
2Cardiff Metropolitan University, Cardiff, Wales, UK
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.146How to use a DOI?
Abstract

Background: Chronic obstructive pulmonary disease (COPD) is an inflammatory condition associated with increased cardiovascular risk. COPD patients have increased aortic stiffness and increased risk of stroke. In addition, increased mid cerebral artery pulsatility index (MCAPI) is associated with increased arterial stiffness and risk of stroke in patients with Diabetes. However, the mechanisms relating to the increased risk of stroke in COPD remain unclear. Therefore, this study aims to investigate the relationship between aortic pulse wave velocity (aPWV) and the MCAPI in COPD patients.

Methods: This Cross-sectional evaluation included 20 COPD patients (mean ±SD, age 69.0 ± 6.3 years) from the ACRADE study. aPWV was measured using the SphygmoCor system and MCAPI using transcranial Doppler ultrasound. In addition, forced expiratory volume in the first second/ forced vital capacity (FEV1/FVC) was measured using spirometry and quality of life was assessed using the St George’s Respiratory Questionnaire (SGRQ). Measures of frailty were assessed using Time-Up-and-Go test (TUG) and the Comprehensive Geriatric Assessment (CGA).

Results: MCAPI was significantly associated with aPWV (r = 0.518, P = 0.033). aPWV was significantly associated with SGRQ disease impact (r = 0.604, P = 0.010) and also associated with TUG (r=0.561, P=0.019) and CGA (r = 0.639, P = 0.006).

Conclusions: These pilot data highlight the association between increased aortic stiffness and increased pulsatile flow velocity transmitted to the cerebral circulation of COPD patients. In addition, COPD symptoms, impact and frailty are both associated with increased aortic stiffness. However, more research is needed to investigate cause and effect between COPD symptoms, impact and its relationship between aPWV and cerebral flow pulsatility.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
105 - 106
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.146How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Mahfoudha Al Shezawi
AU  - John Cockcroft
AU  - Maggie Munnery
AU  - laura Watkeys
AU  - Nichola Gale
AU  - Barry McDonnell
PY  - 2018
DA  - 2018/12/04
TI  - P93 RELATIONSHIP BETWEEN AORTIC PULSE WAVE VELOCITY AND MID CEREBRAL ARTERY PULSATILITY INDEX IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE; PILOT DATA FROM THE ARCADE STUDY
JO  - Artery Research
SP  - 105
EP  - 106
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.146
DO  - 10.1016/j.artres.2018.10.146
ID  - AlShezawi2018
ER  -