Artery Research

Volume 24, Issue C, December 2018, Pages 109 - 109

P104 INFLUENCE OF AGE AND GENDER ON 24-HOUR VARIABILITY OF CENTRAL BLOOD PRESSURE: FINDINGS FROM THE INTERNATIONAL 24-HOUR AMBULATORY AORTIC BLOOD PRESSURE CONSORTIUM (I24ABC)

Authors
Thomas Weber1, Athanase Protogerou2, Siegfried Wassertheurer3, Cristina Giannatasio4, Piotr Jankowski5, Yan Li6, Alessandro Maloberti4, Barry McDonnell7, Carmel McEniery8, Maria Lorenza Muiesan9, Janos Nemcsik10, Anna Paini9, Enrique Rodilla11, Ian Wilkinson8, Robert Zweiker12, James Sharman13
1Cardiology Department, Klinikum Wels-Grieskirchen, Wels, Austria
2Department of Pathophysiology Medical School National and Kapodistrian University of Athens, Greece
3Health & Environment Department, Austrian Institute of Technology, Vienna, Austria
4University Milano-Bicocca, MIlano, Italy
5Jagellonian University, Krakow, Poland
6Shanghai Institute of Hypertension, Shanghai Jiaotong University School of Medicine, Shanghai, China
7Cardiff Metropolitan University, Cardiff, UK
8Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK
9Dipartimento di Scienze Cliniche e Sperimentali, Università di Brescia, Brescia, Italy
10Semmelweis University, Budapest, Hungary
11Hospital de Sagunto, Universidad CEU Cardenal Herrera, Valencia, Spain
12Department of Cardiology, Medical University Graz, Graz, Austria
13Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.157How to use a DOI?
Abstract

Background: Conventional brachial cuff BP is known to vary according to age and gender, but the influence of these factors on 24-hour ambulatory central BP is unknown. We sought to determine this in a large healthy population from 11 centers in Europe and Asia.

Methods: 24-hour ambulatory BP using a validated oscillometric device (Mobilograph, I.E.M, Stolberg, Germany) was performed in 1645 individuals free from antihypertensive drugs. Participants were categorized as young (Y: 13–39 years; M/F:219/112), middle-aged (MA: 40–66 years; M/F:545/553), and older (O: 67–104 years; M/F:86/130). Nighttime/daytime difference (N/D) was defined as nighttime (01.00–06.00) minus daytime (09.00–21.00) values / daytime values.

Results: Averaged 24-hour brachial BP was 125/79 (Y), 128/83 (MA), and 127/77 (O) mmHg. N/D for brachial SBP was −10.3% (Y), −6.4% (MA), and −4.7% (O), but was significantly less pronounced for central SBP: −1% (Y), −3.1% (MA), and −1.9% (O). Men, compared to women, had higher brachial and central SBPs, mainly in younger participants. Brachial pulse pressure (PP) displayed limited and age-dependent circadian variations, whereas central PP was substantially higher at nighttime: N/D was 24% (Y), 9% (MA), and 5.9% (O). Brachial and central PPs were higher in men in the younger group, but higher in women in middle-aged and older groups.

Conclusion: Both age and gender each have a significant influence on 24-hour variability of central BP, but is different than variability in brachial BP. These data have potential implications for refining hypertension diagnosis and management.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
24 - C
Pages
109 - 109
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.157How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Thomas Weber
AU  - Athanase Protogerou
AU  - Siegfried Wassertheurer
AU  - Cristina Giannatasio
AU  - Piotr Jankowski
AU  - Yan Li
AU  - Alessandro Maloberti
AU  - Barry McDonnell
AU  - Carmel McEniery
AU  - Maria Lorenza Muiesan
AU  - Janos Nemcsik
AU  - Anna Paini
AU  - Enrique Rodilla
AU  - Ian Wilkinson
AU  - Robert Zweiker
AU  - James Sharman
PY  - 2018
DA  - 2018/12/04
TI  - P104 INFLUENCE OF AGE AND GENDER ON 24-HOUR VARIABILITY OF CENTRAL BLOOD PRESSURE: FINDINGS FROM THE INTERNATIONAL 24-HOUR AMBULATORY AORTIC BLOOD PRESSURE CONSORTIUM (I24ABC)
JO  - Artery Research
SP  - 109
EP  - 109
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.157
DO  - 10.1016/j.artres.2018.10.157
ID  - Weber2018
ER  -