Artery Research

Volume 24, Issue C, December 2018, Pages 101 - 101

P78 PRESSURE-INDEPENDENT ROLE OF THE AUTONOMIC NERVOUS SYSTEM IN THE REGULATION OF ARTERIAL STIFFNESS IN SUBJECTS WITH ESSENTIAL HYPERTENSION

Authors
Luca Faconti, Bushra Farukh, Philip J. Chowienczyk
King’s College London, UK
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.131How to use a DOI?
Abstract

Objective: To test if arterial stiffness (AS) can be modulated by the autonomic nervous system (ANS) independently of blood pressure (BP) in hypertensive patients.

Material and methods: AS was measured by carotid-femoral pulse wave velocity (cfPWV) using the SphygmoCor device (AtCor Medical, Australia). Mean arterial pressure (MAP) was obtained by pulse-wave analysis of the radial artery and ANS activity was estimated by heart rate variability (HRV) as log-ratio of low-frequency/high-frequency heart rate components (Schiller Medilog AR12plus, United States) in hypertensive subjects (n = 43, 17 female, mean ± SD age 45 ± 13 years, brachial BP 145 ± 17/87 ± 10 mmHg) at rest. All measurements were subsequently repeated during supervised device-guided paced breathing (DGB) and reduction of cardiac pre-load by lower limb venous occlusion (LVO). These interventions, which are known to decrease and increase sympathetic activity, were performed in random order.

Results: DGB reduced HRV by 0.14 [0.07, 0.20] (Mean [95% confidence intervals]) and LVO increased HRV by 0.13 [0.08, 0.18] (both P<0.05). DGB reduced cfPWV by 1.3 [0.9, 1.6] m/s alongside with a reduction in MAP of 6.6 [5.1, 8.1] mmHg (both P < 0.01). By contrast, LVO increased cfPWV by 1.0 [0.6,1.4] m/s (P < 0.01), despite a fall in MAP of 1.5 [0.2,2.7] mmHg (P < 0.05). The difference between effects of DGB and LVO on cfPWV was significant whether adjusted or unadjusted for change in MAP (P < 0.05).

Conclusion: Despite BP-lowering effects, DGB and LVO had opposite effects on HRV and cfPWV. This suggest that the autonomic nervous system has a pressure-independent role in the regulation of AS in hypertension.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
24 - C
Pages
101 - 101
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.131How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Luca Faconti
AU  - Bushra Farukh
AU  - Philip J. Chowienczyk
PY  - 2018
DA  - 2018/12/04
TI  - P78 PRESSURE-INDEPENDENT ROLE OF THE AUTONOMIC NERVOUS SYSTEM IN THE REGULATION OF ARTERIAL STIFFNESS IN SUBJECTS WITH ESSENTIAL HYPERTENSION
JO  - Artery Research
SP  - 101
EP  - 101
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.131
DO  - 10.1016/j.artres.2018.10.131
ID  - Faconti2018
ER  -