NAA1 NICOTINAMIDE RIBOSIDE SUPPLEMENTATION REDUCES AORTIC STIFFNESS AND BLOOD PRESSURE IN MIDDLE-AGED AND OLDER ADULTS
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Purpose: Regular calorie restriction (CR) improves endothelial function and lowers aortic stiffness in older mice and humans; however, adherence to sustained CR remains poor, and possibly unsafe in normal weight older adults. Nicotinamide adenine dinucleotide (NAD+) is an important signaling molecule involved in the beneficial effects of CR and we have recently demonstrated that boosting NAD+ reverses these measures of arterial aging in older mice. The purpose of this study was to determine if supplementation with nicotinamide riboside (NIAGEN®; ChromaDex, Inc.), a naturally occurring precursor to NAD+, would similarly improve vascular function with aging in humans.
Methods: Healthy middle-aged and older adults (65 ± 2 yrs, n = 24) received oral NIAGEN® (500 mg, 2x/day) and placebo capsules for six weeks each in a randomized, placebo-controlled crossover study. Blood pressure (BP), aortic stiffness (carotid-femoral pulse wave velocity [PWV]), and endothelial function, (brachial artery flow-mediated dilation [FMD]), were measured at the end of each intervention phase.
Results: NIAGEN® safely and effectively raised circulating levels of NAD+ and related metabolites. Although no effect was observed on endothelial function, NIAGEN® significantly lowered PWV as well as systolic (SBP) and diastolic blood pressure (DBP) in all subjects (P < 0.05). When separated by baseline BP status, the BP-lowering effect of NIAGEN® was observed in pre-hypertensive (pHTN, n = 13) but not normotensive (N = 11) individuals (P < 0.01). Interestingly, NIAGEN® was lowered in all subjects regardless of baseline BP status.
Conclusion: Chronic NIAGEN® supplementation lowers SBP in pHTN older adults and reduces aortic stiffness, independent of baseline blood pressure status.
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TY - JOUR AU - Christopher Martens AU - Blair Denman AU - Melissa Mazzo AU - Michael Armstrong AU - Nichole Reisdorph AU - Matthew McQueen AU - Michel Chonchol AU - Douglas Seals PY - 2017 DA - 2017/12 TI - NAA1 NICOTINAMIDE RIBOSIDE SUPPLEMENTATION REDUCES AORTIC STIFFNESS AND BLOOD PRESSURE IN MIDDLE-AGED AND OLDER ADULTS JO - Artery Research SP - 49 EP - 49 VL - 20 IS - C SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2017.10.021 DO - https://doi.org/10.1016/j.artres.2017.10.021 ID - Martens2017 ER -