Artery Research

Volume 20, Issue C, December 2017, Pages 57 - 58

4.6 HIPPOCAMPAL CEREBRAL BLOOD FLOW DEPENDS ON SYSTEMIC ENDOTHELIAL FUNCTION IN INDIVIDUALS WITH MILD COGNITIVE IMPAIRMENT: THE TRAIN THE BRAIN-MIND THE VESSEL STUDY

Authors
Rosa Maria Bruno1, Lorenza Pratali2, Rosa Sicari2, Francesco Stea2, Nicoletta Berardi3, Gloria Tognoni1, Ubaldo Bonuccelli1, Lorenzo Ghiadoni1, Stefano Taddei1, Danilo Scelfo4, Laura Biagi4, Michela Tosetti4, Lamberto Maffei3, Eugenio Picano2
1University of Pisa, Pisa, Italy
2Institute of Clinical Physiology – CNR, Pisa, Italy
3Institute of Neuroscience – CNR, Pisa, Italy
4IRCSS Stella Maris, Pisa, Italy
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.044How to use a DOI?
Abstract

Background: Dementia has been recently viewed as a predominantly vascular disorder. Indeed, reduced brain NO availability causes increased ß-amyloid deposition by several mechanisms, including hypoperfusion.

Purpose: To investigate the relationship between cerebral blood flow in the hippocampal and parahippocampal regions (CBF-hipp and CBF-parahipp), crucial areas for memory and processing of non-verbal/spatial information, and systemic endothelial function in individuals with mild cognitive impairment (MCI), a subclinical condition predisposing to dementia.

Methods: CBF-hipp and CBF-parahipp were evaluated by magnetic resonance imaging (arterial spin labeling, GE HDxt 1.5 T Signa Neuro-optimized System) and systemic endothelial function by flow-mediated dilation (FMD) in the brachial artery.

Results: Complete data about CBF and FMD at enrollment were available for 66 individuals with MCI and 32 without (non-MCI). The two groups were matched for age (75 ± 5 vs 74 ± 5 years, p = 0.22), sex (men 45 vs 50%, p = 0.18) and mean BP (96 ± 10 vs 97 ± 9 mmHg, p = 0.41). FMD was significantly lower in MCI than in non-MCI (2.93 ± 2.18 vs 3.74 ± 2.03%, p = 0.02); CBF-hipp (64.3 ± 9.43 vs 69.5 ± 7.03 ml/100 gr/min, p = 0.002) and CBF-parahipp (66.3 ± 8.02 vs 70.0 ± 8.12 ml/100 gr/min, p = 0.002) were significantly lower in MCI as well. Among MCI, FMD was significantly correlated with CBF-parahipp (r = 0.26, p = 0.03) and CBF-hipp (r = 0.32, p = 0.009). In multiple regression models, including age, sex, mean BP, BMI, brachial artery diameter as confounders, FMD remained an independent determinant of CBF-parahipp (beta = 0.93, r2 = 0.063, p = 0.04) and CBF-hipp (beta = 1.31, r2 = 0.089, p = 0.01). Nor CBF-parahipp (r = −0.13, p = 0.48) neither CBF-hipp (r = 0.05, p = 0.80) were correlated with FMD in non-MCI group.

Conclusions: An independent association between hippocampal and parahippocampal CBF and systemic endothelial function is present in individuals with MCI.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
57 - 58
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.044How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Rosa Maria Bruno
AU  - Lorenza Pratali
AU  - Rosa Sicari
AU  - Francesco Stea
AU  - Nicoletta Berardi
AU  - Gloria Tognoni
AU  - Ubaldo Bonuccelli
AU  - Lorenzo Ghiadoni
AU  - Stefano Taddei
AU  - Danilo Scelfo
AU  - Laura Biagi
AU  - Michela Tosetti
AU  - Lamberto Maffei
AU  - Eugenio Picano
PY  - 2017
DA  - 2017/12/06
TI  - 4.6 HIPPOCAMPAL CEREBRAL BLOOD FLOW DEPENDS ON SYSTEMIC ENDOTHELIAL FUNCTION IN INDIVIDUALS WITH MILD COGNITIVE IMPAIRMENT: THE TRAIN THE BRAIN-MIND THE VESSEL STUDY
JO  - Artery Research
SP  - 57
EP  - 58
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.044
DO  - 10.1016/j.artres.2017.10.044
ID  - Bruno2017
ER  -