Artery Research

Volume 20, Issue C, December 2017, Pages 76 - 76

P83 A PILOT STUDY TO ASSESS PEAK SYSTOLIC VELOCITY AS A POSSIBLE MARKER OF ATHEROSCLEROTIC BURDEN USING ULTRASOUND

Authors
Carola Koenig1, Mark Atherton1, Marco Cavazzuti1, Sudarshan Ramachandran2, Corinna Gomm2, Richard Strange3, Ian Halliday4, Torsten Schenkel4
1Brunel University London, UK
2Heart of England Foundation NHS Trust, UK
3Keele University, UK
4Sheffield Hallam University, UK
Available Online 6 December 2017.
DOI
https://doi.org/10.1016/j.artres.2017.10.099How to use a DOI?
Abstract

Introduction: Ischemic heart disease (IHD) has been associated with lower peak systolic velocity (PSV) on penile Doppler measurements [1]. This study establishes whether carotid ultrasound (US) PSV was associated with computational fluid dynamics (CFD) outputs, which in turn may contribute to IHD pathogenesis.

Methods: A sample of 57 subjects (with IHD: 27, without IHD: 30) had US velocity profiles (left- common carotid artery) determined between 10–12 equi-spaced points. Bezier curve fitting was used to fit the profile through the measured velocity points for a normalised diameter. PSV was correlated against CFD results such as wall shear stress (WSS) [2]. Difference in PSV between individuals with/without IHD was studied via t-test. Linear regression was carried out to see if peak systolic velocity was associated with CFD outputs. Any significant associations were analysed within stratified groups (with/without IHD).

Results: PSV was significantly lower (p = 0.042) in subjects with IHD (with IHD: 53.6±17.3 cm/s, without IHD: 62.8±16.1 cm/s). PSV was associated with carotid bulb average pressure drop (p < 0.001), area of average bulb WSS (<1 Pa: p = 0.016, <2 Pa: p = 0.006, <3 Pa: p = 0.001). All the above associations remained significant in individuals with IHD (average bulb pressure drop: p = 0.001, average bulb WSS (<1 Pa: p = 0.013, <2 Pa: p = 0.008, <3 Pa: p = 0.003). In subjects without IHD, PSV was associated with only average bulb pressure drop (p = 0.016).

Conclusions: This study suggests that further work on PSV and its associations with CFD outputs is required in individuals with and without IHD in various vascular beds.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
76 - 76
Publication Date
2017/12
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.1016/j.artres.2017.10.099How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Carola Koenig
AU  - Mark Atherton
AU  - Marco Cavazzuti
AU  - Sudarshan Ramachandran
AU  - Corinna Gomm
AU  - Richard Strange
AU  - Ian Halliday
AU  - Torsten Schenkel
PY  - 2017
DA  - 2017/12
TI  - P83 A PILOT STUDY TO ASSESS PEAK SYSTOLIC VELOCITY AS A POSSIBLE MARKER OF ATHEROSCLEROTIC BURDEN USING ULTRASOUND
JO  - Artery Research
SP  - 76
EP  - 76
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.099
DO  - https://doi.org/10.1016/j.artres.2017.10.099
ID  - Koenig2017
ER  -