Artery Research

Volume 20, Issue C, December 2017, Pages 75 - 75

P80 IDENTIFICATION OF RADIAL VASCULAR WALL ABNORMALITIES BY VERY-HIGH FREQUENCY ULTRASOUND IN PATIENTS WITH FIBROMUSCULAR DYSPLASIA: THE FUCHSIA STUDY

Authors
Rosa Maria Bruno1, Nicole Di Lascio2, Daniela Guarino1, Saverio Vitali1, Piercarlo Rossi1, Davide Caramella1, Stephane Laurent3, Pierre Boutouryie3, Stefano Taddei1, Lorenzo Ghiadoni1, Francesco Faita2
1University of Pisa, Pisa, Italy
2Institute of Clinical Physiology – CNR, Pisa, Italy
3Hôpital Européen Georges Pompidou, INSERM, Paris, France
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.096How to use a DOI?
Abstract

Aim: This case-control study is aimed at identifying radial vascular wall abnormalities in patients with fibromuscular dysplasia (FMD).

Methods: High-frequency ultrasound scans of radial arteries were obtained by VevoMD (70 MHz probe, FUJIFILM, VisualSonics). Radial wall showed two echogenic interfaces: the 1st (lumen-media) and the 2nd (media-adventitia). Intima-media (IMT), adventitia (AT), and global thickness (IMAT) and wall cross-sectional area (WCSA) Measured. Vascular wall disarray was assessed calculating the root mean square error (RMSE) between 20 gray-level profiles crossing the two interfaces and the profile obtained averaging them, normalized for the maximum value of the corresponding mean profile (RMSE/mean).

Results: 11 treated hypertensive female FMD patients and 8 healthy controls (C) were enrolled (age 52±5 vs 45±13years, p = 0.51; BMI 26±3 vs 23±3kg/mg, p = 0.12; mean BP 97±7 vs 85±10 mmHg, p = 0.01). Radial lumen was similar; IMT (0.166±0.037 vs 0.128±0.022mm, p = 0.03), AT (0.114±0.029 vs 0.083±0.019mm, p = 0.008) and IMAT (0.281±0.042 vs 0.211±0.027mm, p = 0.003) were higher in FMD. Wall/lumen ratio was similar and WCSA increased in FMD.

The maximum values of 1st (121±43 vs 157±22, p = 0.09) and 2nd interface 109±44 vs133±18, p = 0.09) tended to be lower, whereas RMSE/mean was higher in FMD (1st 1.31±0.24 vs 0.83±0.32, p = 0.006; 2nd 1.37±0.38 vs 0.94±0.32, p = 0.03). The difference was attenuated for the 1st but not for the 2nd interface when considering age and mean BP as covariates (p = 0.054 and p = 0.016 respectively).

Conclusions: The radial artery wall of hypertensive FMD patients shows increased thickness and its ultrastructure is characterized of loss of echogenicity and inhomogeneity of the two echogenic layers.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
75 - 75
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.096How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Rosa Maria Bruno
AU  - Nicole Di Lascio
AU  - Daniela Guarino
AU  - Saverio Vitali
AU  - Piercarlo Rossi
AU  - Davide Caramella
AU  - Stephane Laurent
AU  - Pierre Boutouryie
AU  - Stefano Taddei
AU  - Lorenzo Ghiadoni
AU  - Francesco Faita
PY  - 2017
DA  - 2017/12/06
TI  - P80 IDENTIFICATION OF RADIAL VASCULAR WALL ABNORMALITIES BY VERY-HIGH FREQUENCY ULTRASOUND IN PATIENTS WITH FIBROMUSCULAR DYSPLASIA: THE FUCHSIA STUDY
JO  - Artery Research
SP  - 75
EP  - 75
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.096
DO  - 10.1016/j.artres.2017.10.096
ID  - Bruno2017
ER  -