Artery Research

Volume 20, Issue C, December 2017, Pages 74 - 74

P77 NEAR INFRARED SPECTROSCOPY (NIRS) CAN DETECT DIFFERENCES IN MICROVASCULAR REACTIVE HYPERAEMIA IN THE PRESENCE OF HYPERTENSION

Authors
Siana Jones, Chloe Park, Nish Chaturvedi, Alun Hughes
University College London, UK
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.093How to use a DOI?
Abstract

Background: Hypertension has adverse effects on microvascular function but there are limited methods that permit non-invasive assessment of the microcirculation in man in vivo. We used Near Infrared Spectroscopy (NIRS) to assess microvascular reactive hyperaemia in skeletal muscle following a short period of ischemia. We tested if differences between normotensive and hypertensive individuals could be detected.

Methods: Older adults enrolled in a population-based cohort study underwent measurements of oxy-Hb changes during a 30-second arterial occlusion and hyperaemic response using NIRS (Portamon, Artinis). Time-to-peak hyperaemic response was calculated. Hypertension diagnosis was determined by questionnaire and clinic blood pressure (BP) (diastolic BP > 90 mmHg or systolic BP > 140 mmHg). Diabetes diagnosis and information about medication were determined by questionnaire. Data are mean (SD) or adjusted mean±SEM. Multivariable linear regression was used. Associations with hypertension were adjusted for age, gender, ethnicity and presence of diabetes.

Results: 129 participants (99 = male, 72(6) years old, 74(57%) hypertensive participated). Time-to-peak hyperaemic response was significantly longer in hypertensive than normotensive participants after adjustment for age and gender (12.5±0.49 versus 10.5±0.57seconds, p = 0.06). This association persisted after adjustment for ethnicity and the presence of diabetes (12.6±0.50 versus 10.5±0.57, p = 0.03).

Conclusion: Hypertension is associated with impairment of post-ischemic reactive hyperaemia in skeletal muscle microvasculature. Differences between hypertensive and normotensive older adults can be detected non-invasively using NIRS.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
74 - 74
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.093How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Siana Jones
AU  - Chloe Park
AU  - Nish Chaturvedi
AU  - Alun Hughes
PY  - 2017
DA  - 2017/12/06
TI  - P77 NEAR INFRARED SPECTROSCOPY (NIRS) CAN DETECT DIFFERENCES IN MICROVASCULAR REACTIVE HYPERAEMIA IN THE PRESENCE OF HYPERTENSION
JO  - Artery Research
SP  - 74
EP  - 74
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.093
DO  - 10.1016/j.artres.2017.10.093
ID  - Jones2017
ER  -