Artery Research

Volume 20, Issue C, December 2017, Pages 89 - 89

P98 EFFECT OF LONG-TERM ANDROGENIC TREATMENT ON THE STRUCTURAL AND FUNCTIONAL PROPERTIES OF THE GREAT ARTERIES OF FEMALE TRANSSEXUALS

Authors
Flavia Cunha1, Luiz Bortolotto1, Valeria Costa-Hong1, Elaine Costa2, Maria Sircilli2, Tania Bachega2, Berenice Mendonça2, Sorahia Domenice2
1Hypertension Unity, Heart Institute (InCor), Hospital das Clinicas da FMUSP, Brazil
2Endocrinology Department, Hospital das Clinicas da FMUSP, Brazil
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.134How to use a DOI?
Abstract

Background: Androgens act directly on the vasculature through your connection to the androgen receptor in the vascular wall, and can promote changes in structural and functional vascular properties.

Objective: To evaluate the structural and functional properties of large arteries in TF in prolonged use of testosterone esters and compare them with those of a control group men and women.

Patients and methods: 42 patients with diagnosis of TF (42±10 years) in treatment with testosterone esters for at least 1 year (1–38 years) and 147 healthy controls matched for age and BMI were submitted to evaluation of carotid parameters by radiofrequency ultrasound (WTS®): intima media thickness (IMT), diameter and relative distension. The carotid-femoral pulse wave velocity (PWVcf) was measured by Complior® device.

Results: The TF showed higher (p < 0.01) PWVcf (7.2±0.8 m/s) than the male controls (6.6±0.9 m/s), but not than female controls (7±1 m/s). When categorized by age, considering median values of age, TF≥42 years showed higher PWVcf than male and female controls, independently of BP values. There is no diferences in carotid parameters between TF and control groups, but obese TF presented higher carotid diameter (6944±527 vs. 6438±555 μm and IMT (691±72 vs. 601±126 μm), and lower carotid distension (4,8±1,5 vs. 6,5±2,1%) than lean TF. The PWVcf was significantly correlated to age (r = 0.63), time of androgenic treatment (r = 0.37) and waist-hip ratio (0.39) in TF.

Conclusion: Older TF subjects and TF with prolonged treatment had higher aortic stiffness. Obese TF presented worst carotid structural and functional markers

Open Access
This is an open access article distributed under the CC BY-NC license.

Download article (PDF)
View full text (HTML)

Journal
Artery Research
Volume-Issue
20 - C
Pages
89 - 89
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.134How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Flavia Cunha
AU  - Luiz Bortolotto
AU  - Valeria Costa-Hong
AU  - Elaine Costa
AU  - Maria Sircilli
AU  - Tania Bachega
AU  - Berenice Mendonça
AU  - Sorahia Domenice
PY  - 2017
DA  - 2017/12/06
TI  - P98 EFFECT OF LONG-TERM ANDROGENIC TREATMENT ON THE STRUCTURAL AND FUNCTIONAL PROPERTIES OF THE GREAT ARTERIES OF FEMALE TRANSSEXUALS
JO  - Artery Research
SP  - 89
EP  - 89
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.134
DO  - 10.1016/j.artres.2017.10.134
ID  - Cunha2017
ER  -