Artery Research

Volume 20, Issue C, December 2017, Pages 99 - 99

P21 REDUCTION OF CARDIAC PRE-LOAD HAS ANTITHETICAL EFFECTS ON BLOOD PRESSURE AND ARTERIAL STIFFNESS: IS BLOOD PRESSURE THE MAIN DETERMINANT OF WITHIN-SUBJECT VARIATION IN PULSE WAVE VELOCITY?

Authors
Luca Faconti1, Bushra Farukh2, Andrii Boguslavskyi2, Phil Chowienczyk2
1Department of Clinical Pharmacology, King’s College London, UK
2King’s College London British Heart Foundation, Department of Clinical Pharmacology, St Thomas’ Hospital, London, UK
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.162How to use a DOI?
Abstract

Objective: Blood pressure (BP) is considered the most important determinant of within-subject variation in pulse wave velocity (PWV) and the possibility of altering arterial stiffness independently of BP is still a matter of debate. When investigating acute effects of a reduction in cardiac pre-load, we hypothesised that this would decrease BP and PWV.

Design and methods: Hypertensive patients (mean±SD age 44±14 years, n = 45) had brachial BP measurements (OMRON), central BP recorded by radial pulse wave analysis (SphygmoCor) and estimation of aortic PWV (aoPWV) by trans-thoracic echocardiography. Carotid-femoral PWV (cfPWV) was also evaluated by SphygmoCor in n = 17. Measurements were performed before and after (>5 minutes) supra-diastolic, sub-systolic pressure inflation of thigh cuffs in order to decrease venous return from the lower limbs. Evaluation of inferior vena cava (IVC) diameter was used to assess pre-load.

Results: Leg cuff-inflation was effective in reducing cardiac pre-load (change in IVC diameter (mean±SE) from 1.6±0.4 cm to 1.3±0.4 cm, p < 0.01) and decreased both brachial and central SBP (−3±0.9 mmHg and −3.6±1.2 mmHg respectively, both p < 0.05) while change in DBP (0.8±0.9 mmHg) and heart rate (−0.1±0.6 bpm) were not significant.

By contrast, aoPWV increased by 0.8±0.35 m/s (p < 0.01) and cfPWV by 1.05±0.33 m/s (p = 0.014).

Conclusions: Contrary to our hypothesis, acute reduction of cardiac pre-load significantly decreased BP but had an opposite effect on PWV. This could be mediated by an increase in sympathetic tone triggered by reduction in circulating blood volume; sympathetic tone might affect PWV independently of BP.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
99 - 99
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.162How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Luca Faconti
AU  - Bushra Farukh
AU  - Andrii Boguslavskyi
AU  - Phil Chowienczyk
PY  - 2017
DA  - 2017/12/06
TI  - P21 REDUCTION OF CARDIAC PRE-LOAD HAS ANTITHETICAL EFFECTS ON BLOOD PRESSURE AND ARTERIAL STIFFNESS: IS BLOOD PRESSURE THE MAIN DETERMINANT OF WITHIN-SUBJECT VARIATION IN PULSE WAVE VELOCITY?
JO  - Artery Research
SP  - 99
EP  - 99
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.162
DO  - 10.1016/j.artres.2017.10.162
ID  - Faconti2017
ER  -