5.5 AGE-DEPENDENT TELOMERE ATTRITION, SHORT TELOMERES AND ATHEROSCLEROSIS

Simon Toupance; Anna Kearney-Schwartz; Mohamed Temmar; Cécile Lakomy; Carlos Labat; Patrick Rossignol; Faiez Zannad; Patrick Lacolley; Abraham Aviv; Athanase Benetos

doi:10.1016/j.artres.2016.10.033

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Volume 16, Issue C, December 2016, Pages 57 - 58

5.5 AGE-DEPENDENT TELOMERE ATTRITION, SHORT TELOMERES AND ATHEROSCLEROSIS

Authors

Simon Toupance¹, Anna Kearney-Schwartz², Mohamed Temmar³, Cécile Lakomy¹, Carlos Labat¹, Patrick Rossignol⁴, Faiez Zannad⁴, Patrick Lacolley¹, Abraham Aviv⁵, Athanase Benetos²

¹INSERM UMRS 1116, Université de Lorraine, Nancy, France

²Département de Médecine Gériatrique, CHU de Nancy, France

³Cardiology Center, Ghardaia, Algeria

⁴CIC-P Pierre Drouin, CHU de Nancy, France

⁵Center of Human Development and Aging, Rutgers University, NJ, USA

Available Online 24 November 2016.

DOI: 10.1016/j.artres.2016.10.033 How to use a DOI?
Abstract: Background: Short leukocyte telomere length (LTL) is associated with atherosclerosis. The prevailing view is this association exists since LTL is a biomarker of cumulative inflammation and oxidative stress during adult life. However recent studies show that LTL in adults is defined mainly by LTL at birth and attrition during childhood. Therefore we can suggest that short LTL might precede clinical expression of atherosclerosis.

Objectives: To examine the directionality in the relation between carotid atheroma and LTL dynamics.

Methods: LTL was measured by TRF in samples donated 9 years apart on average by 257 men and women aged 41 to 80 at the inclusion.

Results: LTL attrition during follow-up (FU) period was 25±17 bp/year. No relation was observed between LTL attrition and presence of carotid atherosclerotic plaques (PCAP). Baseline (BL)-LTL was highly correlated (r=0.96, p<0.0001) with FU-LTL. In 87.9%of the subjects LTL ranking by deciles was the same 1 decile at BL and FU. BL- and FU-LTL were inversely associated with PCAP (p<0.01). After adjusting for age and gender, BL-LTL was 6.50±0.04 Kb in subjects without PCAP 6.46±0.06 in those with PCAP only at the FU visit and 6.27±0.06 in those with PCAP in both BL and FU visits (p=0.027). LTL attrition was the same in these groups.

Conclusions: LTL attrition in adulthood is not influenced by PCAP and does not play a significant role in LTL ranking. By contrast, patients with shorter telomeres present CAP earlier in life. Telomere length could be considered as a bio-determinant for atherosclerosis.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 16 - C
Pages: 57 - 58
Publication Date: 2016/11/24
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2016.10.033 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Simon Toupance
AU  - Anna Kearney-Schwartz
AU  - Mohamed Temmar
AU  - Cécile Lakomy
AU  - Carlos Labat
AU  - Patrick Rossignol
AU  - Faiez Zannad
AU  - Patrick Lacolley
AU  - Abraham Aviv
AU  - Athanase Benetos
PY  - 2016
DA  - 2016/11/24
TI  - 5.5 AGE-DEPENDENT TELOMERE ATTRITION, SHORT TELOMERES AND ATHEROSCLEROSIS
JO  - Artery Research
SP  - 57
EP  - 58
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.033
DO  - 10.1016/j.artres.2016.10.033
ID  - Toupance2016
ER  -

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