Artery Research

Volume 16, Issue C, December 2016, Pages 64 - 64

7.7 THE EFFECT OF MARINE N-3 POLYUNSATURATED FATTY ACIDS ON CARDIAC AUTONOMIC AND HEMODYNAMIC FUNCTION IN PATIENTS WITH PSORIATIC ARTHRITIS: A RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

Authors
Salome Kristensen, Erik Berg Schmiddt, Annette Schlemmer, Claus Rasmussen, Esther Lindgreen, Martin Berg Johansen, Jeppe Hagstrup Christensen
Aalborg University Hospital, Aalborg, Denmark
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.053How to use a DOI?
Abstract

Background: Patients with psoriatic arthritis are at high cardiovascular risk. Marine n-3 polyunsaturated fatty acids (PUFA) may reduce the incidence of cardiovascular disease. The aim of this study was to investigate the effect of marine n-3 PUFA on cardiac autonomic function and vascular function in patients with psoriatic arthritis.

Methods: The study was conducted as a randomized, double-blind, placebo-controlled trial, where 145 patients with psoriatic arthritis were supplemented with 3 g of n-3 PUFA or olive oil (control) daily for 24 weeks. Blood pressure, heart rate, HRV, central blood pressure, pulse wave velocity (PWV) and fatty acid composition of granulocytes, were determined.

Results: At baseline we found a significant difference in the HRV parameter RR when comparing subjects with the highest vs the lowest fish intake (p = 0.03).

After supplementation for 24 weeks there was a trend towards an increase in RR (p= 0.13) and decrease in heart rate (p = 0.12) comparing the n-3 PUFA group with the control group. However, per-protocol analysis (performed on participants who completed the trial with a good compliance) showed significantly increased RR (p = 0.01) and lowered heart rate (p = 0.01) in the n-3 PUFA supplemented patients compared to controls. Blood pressure, PWV and central blood pressure did not change after supplementation with n-3 PUFA.

Conclusions: Marine n-3 PUFA increased HRV in patients with psoriatic arthritis which may suggest a protective effect of n-3 PUFA against cardiovascular disease in this population.

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Journal
Artery Research
Volume-Issue
16 - C
Pages
64 - 64
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.053How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Salome Kristensen
AU  - Erik Berg Schmiddt
AU  - Annette Schlemmer
AU  - Claus Rasmussen
AU  - Esther Lindgreen
AU  - Martin Berg Johansen
AU  - Jeppe Hagstrup Christensen
PY  - 2016
DA  - 2016/11/24
TI  - 7.7 THE EFFECT OF MARINE N-3 POLYUNSATURATED FATTY ACIDS ON CARDIAC AUTONOMIC AND HEMODYNAMIC FUNCTION IN PATIENTS WITH PSORIATIC ARTHRITIS: A RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL
JO  - Artery Research
SP  - 64
EP  - 64
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.053
DO  - 10.1016/j.artres.2016.10.053
ID  - Kristensen2016
ER  -