Artery Research

Volume 16, Issue C, December 2016, Pages 79 - 79

12.9 VENTRICULAR ARTERIAL COUPLING IN ISOMETRIC HANDGRIP TEST IN UNTREATED HYPERTENSIVE PATIENTS

Authors
Anna Bogomaz, Yulia Kotovskaya, Zhanna Kobalava
Peoples’ Friendship University of Russia, Moscow, Russia
Available Online 24 November 2016.
DOI
https://doi.org/10.1016/j.artres.2016.10.107How to use a DOI?
Abstract

Aim: To evaluate cardiovascular adaptation to increased afterload during handgrip isometric exercise (HIE) in untreated hypertensive patients.

Methods: 75 untreated hypertensive patients (age 54±7years, 44 males, BP 153/93 mmHg) underwent simultaneous EchoCG and blood pressure (BP) acquisition at rest and during HIE. End-systolic pressure was determined as 0,9 x brachial systolic BP (SBP). Arterial elastance (Ea) and LV elastance (Ees) were calculated as end-systolic pressure (ESP) /stroke volume (SV) and ESP/end-systolic volume (ESV). Ventricular-arterial coupling index was assessed as Ea/Ees. Efficiency of left ventricle (ELV) was evaluated by stroke work (SW)/pressure-volume area (PVA) ratio. SW=ESPхSV, PVA=SW+PE (ESPхESV/2-end diastolic pressure xESP/4). p<0,05 was considered significant.

Results: Ea/Ees<0,5 was found in 76% (n=57, 18 female) before HIE. In 38% (n=22, 4 (23%) female) Ea, Ees, Ea/Ees and SW/PVA did not change significantly. In 11% there was further decrease of Ea/Ees associated with significant increase of ELV. In 51% (n=29, 14 (49%) female) Ea/Ees increased due to increase of Ea from 1,98±0,32 to 2,35±0,41 (p<0,05) while Ees increased from 5,95±2,2 to 4,58±1,0 (p<0,05). Ea/Ees increase was associated with decrease of ELV from 0,89±0,02 to 0,84±0,02 (p<0,05) indicating cardiovascular misadaptation to HIE.

In subjects (n=18, 3 female) with normal Ea/Ees 0,5–1,2 before HIE Ea/Ees and ELV did not change in 8 (49%, all males). In 10 subjects (3 female) Ea/Ees decreased due to significant increase of Ees (from 3,15±0,68 to 5,02±1,34 (p<0,05), and ELV increased from 0,81±0,03 to 0,88±0,01 (p<0,05).

Conclusion: Cardiovascular misadaptation to afterload is the most prevalent type of reaction to HIE in subjects with decreased baseline Ea/Ees and may be also observed in subjects with normal baseline ventricular-arterial coupling. This misadaptation in subjects with baseline ventricular arterial uncoupling is associated with female gender.

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Journal
Artery Research
Volume-Issue
16 - C
Pages
79 - 79
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.1016/j.artres.2016.10.107How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Anna Bogomaz
AU  - Yulia Kotovskaya
AU  - Zhanna Kobalava
PY  - 2016
DA  - 2016/11/24
TI  - 12.9 VENTRICULAR ARTERIAL COUPLING IN ISOMETRIC HANDGRIP TEST IN UNTREATED HYPERTENSIVE PATIENTS
JO  - Artery Research
SP  - 79
EP  - 79
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.107
DO  - https://doi.org/10.1016/j.artres.2016.10.107
ID  - Bogomaz2016
ER  -