Artery Research

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Volume 16, Issue C, December 2016, Pages 75 - 75

11.6 THE AORTIC-TO-BRACHIAL STIFFNESS GRADIENT AND AORTIC RESERVOIR-EXCESS PRESSURE IN A DIALYSIS POPULATION

Authors
Catherine Fortier1, Marie-Pier Desjardins1, Aboubacar Sidibe1, Mathieu Allard1, Martin G. Schultz2, James E. Sharman2, Mohsen Agharazii1
1Centre de Recherche du CHU de Quebec, Division of Nephrology, Faculty of Medicine, Université Laval, Quebec City, Canada
2Menzies Institute for Medical Research, University of Tasmania, Australia
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.094How to use a DOI?
Abstract

Background: Aortic reservoir function is associated with increased cardiovascular events. Patients with chronic kidney disease in need of dialysis have increased aortic stiffness and reversal of the aortic-to-brachial stiffness gradient, which could impair aortic reservoir function. The aim of this study was to determine the relationship between the aortic-to-brachial stiffness gradient and aortic reservoir function.

Methods: Among 310 patients with chronic kidney disease on dialysis, aortic and brachial stiffness were measured by pulse wave velocity (PWV), with the aortic-to-brachial stiffness gradient calculated by the ratio of aortic and brachial PWV (PWV ratio). Aortic reservoir function was measured by radial tonometry-derived reservoir pressure (RP) and excess pressure (XSP) integrals.

Results: RP was significantly and positively associated with PWV ratio (Standardized β=0.168 p<0.001) independent from age, sex, height, mean blood pressure, heart rate, treatment by hemodialysis and diabetes status (Model adjusted R2=0.68 p<0.001). On the other hand, XSP, which was significantly correlated to PWV ratio (Standardized β=0.20 p<0.001), lost its relation in multivariable adjusted model, and instead was predicted by age, heart rate, mean blood pressure and diabetes status, but this was only a weak model (Adjusted R2=0.15 p<0.001).

Conclusion: Among patients with chronic kidney disease on dialysis, the aortic-to-brachial stiffness gradient is an independent predictor of adverse aortic reservoir function.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
16 - C
Pages
75 - 75
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.094How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Catherine Fortier
AU  - Marie-Pier Desjardins
AU  - Aboubacar Sidibe
AU  - Mathieu Allard
AU  - Martin G. Schultz
AU  - James E. Sharman
AU  - Mohsen Agharazii
PY  - 2016
DA  - 2016/11/24
TI  - 11.6 THE AORTIC-TO-BRACHIAL STIFFNESS GRADIENT AND AORTIC RESERVOIR-EXCESS PRESSURE IN A DIALYSIS POPULATION
JO  - Artery Research
SP  - 75
EP  - 75
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.094
DO  - 10.1016/j.artres.2016.10.094
ID  - Fortier2016
ER  -