Artery Research

Volume 12, Issue C, December 2015, Pages 27 - 28

P6.13 AMBULATORY AND OFFICE CENTRAL SYSTOLIC BLOOD PRESSURE IS MORE CLOSELY ASSOCIATED WITH LEFT VENTRICULAR MASS THAN AMBULATORY AND OFFICE PERIPHERAL SYSTOLIC BLOOD PRESSURE IN A YOUNG NORMOTENSIVE POPULATION

Authors
Maria Kearney*1, James Thomas1, Niamh Chapman1, Laura Watkeys1, Margaret Munnery2, John Cockcroft2, Rob Shave1, Carmel McEniery3, Eric Stöhr1, Barry McDonnell1
1Cardiff Metropolitan University, Cardiff, UK
2Wales Heart Research Institute, Cardiff, UK
3University of Cambridge, Cambridge, UK
Available Online 23 November 2015.
DOI
https://doi.org/10.1016/j.artres.2015.10.297How to use a DOI?
Abstract

Background: High blood pressure (BP) at a young age and increased left ventricular mass (LVM) are associated with increased risk of future cardiovascular mortality. In addition, ambulatory 24-hour central systolic BP (24cSBP) is more closely associated with LVM than either 24-hour peripheral SBP (24pSBP) or office measurements of pSBP and cSBP. However these associations have only been observed in older hypertensive patients. The purpose of this study was to determine (1) if BP was associated with LVM, and (2) which method of BP measurement was more strongly associated with LVM in a young healthy normotensive population.

Methods: Forty-one adults (23±4yrs, 27% male) took part in the study. LVM was measured using 2-D echocardiography (Vividq, GE) and indexed to body surface area (LVMi). Both office and 24-hour pSBP and cSBP were measured using the Mobil-O-Graph system (IEM, Germany). cSBP’s were calculated using brachial mean and diastolic pressures (MAP-cal).

Results: Participants had normal office pSBP (117 ±10 mmHg) and LVMi (79 ±17 g/m2) values. On average, office cSBP (128 ±19 mmHg) was significantly higher than 24cSBP (123 ±14 mmHg, P<0.05). LVMi was not associated with pSBP (r=0.275, P=0.82) and weakly associated with 24pSBP (r=0.320, P=0.041). However the strongest associations with LVMi were with cSBP MAP-cal (r=0.506, P=0.001) and 24cSBP MAP-cal (r=0.556, P<0.0001).

Conclusion: In the current young normotensive population, both office cSBP and 24cSBP were more closely associated with LVMi than peripheral measures of SBP. These findings may have implications for the progression and potential treatment of hypertension-induced target organ damage.

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Journal
Artery Research
Volume-Issue
12 - null
Pages
27 - 28
Publication Date
2015/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.1016/j.artres.2015.10.297How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Maria Kearney*
AU  - James Thomas
AU  - Niamh Chapman
AU  - Laura Watkeys
AU  - Margaret Munnery
AU  - John Cockcroft
AU  - Rob Shave
AU  - Carmel McEniery
AU  - Eric Stöhr
AU  - Barry McDonnell
PY  - 2015
DA  - 2015/11
TI  - P6.13 AMBULATORY AND OFFICE CENTRAL SYSTOLIC BLOOD PRESSURE IS MORE CLOSELY ASSOCIATED WITH LEFT VENTRICULAR MASS THAN AMBULATORY AND OFFICE PERIPHERAL SYSTOLIC BLOOD PRESSURE IN A YOUNG NORMOTENSIVE POPULATION
JO  - Artery Research
SP  - 27
EP  - 28
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.297
DO  - https://doi.org/10.1016/j.artres.2015.10.297
ID  - Kearney*2015
ER  -