Artery Research

Volume 12, Issue C, December 2015, Pages 37 - 37

P8.14 ELASTIC MODULUS OF HUMAN AORTAS AS A MEASURE OF STIFFNESS

Authors
Kathleen Connolly*1, Ashraf Khir2, Ye Li2, Yasmin Yasmin1, Ian Wilkinson1
1University of Cambridge, Cambridge, UK
2Brunel University, London, UK
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.336How to use a DOI?
Abstract

Background: Although arterial stiffness is of clinical interest, data on the elastic modulus of the human aortic wall are scarce. The aim of this work is to directly measure the elastic modulus of human aorta ex vivo.

Methods: Using a standard tensiometer, we measured the elastic modulus (E) of human aortic rings (n=205). Wall thickness and diameter were measured, and the pulse wave velocity (PWV) for each aorta was calculated using Moens-Kortweg equations. The results were analysed based on age, gender and aortic site, then compared with data obtained in living subjects using MRI (n=160).

Results: At 100mmHg pressure, E of aortic rings increased with age, with a commiserate increase in PWV: under 30 years = 3.73±0.49; 30–39 years = 3.32±0.58; 40–49 years = 3.32±0.49; 50–59 years = 3.55±1.00; 60–69 years = 4.05±1.21; 70–79 years = 4.52±1.26; 80–89 years=5.59±0.39 m/s. There was no significant difference in either E or PWV between genders. There was also no significant difference in E or PWV based on aortic site, likely due to under-representation of most sites.

PWV measured in vivo using MRI was higher every age: under 30 years = 3.96±0.51; 30–39 years = 4.47±0.61; 40–49 years = 4.85±0.75; 50–59 years = 5.97±1.14; 60–69 years = 6.64±1,16; 70–79 years = 9.40±4.24 m/s. The difference between in vivo and ex vivo measurements increased with age.

Conclusions: PWV calculated from ex vivo E measurements reflect established physiological patterns, suggesting that direct elastic modulus measurement may be an acceptable method for analysing stiffness in aortic tissue.

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Journal
Artery Research
Volume-Issue
12 - C
Pages
37 - 37
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.336How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Kathleen Connolly*
AU  - Ashraf Khir
AU  - Ye Li
AU  - Yasmin Yasmin
AU  - Ian Wilkinson
PY  - 2015
DA  - 2015/11/23
TI  - P8.14 ELASTIC MODULUS OF HUMAN AORTAS AS A MEASURE OF STIFFNESS
JO  - Artery Research
SP  - 37
EP  - 37
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.336
DO  - 10.1016/j.artres.2015.10.336
ID  - Connolly*2015
ER  -