3.7 Exercise Systolic Blood Pressure Response And Incident Depressive Symptoms – The Maastricht Study

DOI

10.2991/artres.k.191224.020How to use a DOI?

Abstract

Background: Exaggerated exercise systolic blood pressure (SBP) is a modifiable risk factor associated with vascular dysfunction. Vascular dysfunction may contribute to the development of late-life depression, but the association between exercise SBP and incident depressive symptoms is unknown. Therefore, we investigated whether an exaggerated exercise SBP is associated with a higher risk of depressive symptoms over time.

Methods: Longitudinal data from the population-based Maastricht Study, with only individuals free of depressive symptoms at baseline included (n = 2,121; 51.3% men; age 59.5 ± 8.5 years). Exercise SBP was measured at baseline with a submaximal exercise cycle test. We calculated a composite score of exercise SBP based on 4 standardized exercise SBP measures: SBP at moderate workload, SBP at peak exercise, SBP change per minute during exercise and SBP 4 minutes after exercise. Clinically relevant depressive symptoms were determined annually at follow-up and defined as a Patient Health Questionnaire score of > = 10.

Results: After a mean follow-up of 3.9 years, 175 participants (8.3%) had incident clinically relevant depressive symptoms. A1 standard deviation higher exercise SBP composite score was associated with a higher incidence of clinically relevant depressive symptoms (hazard ratio: 1.27 [95% confidence interval: 1.04–1.54]). Results were adjusted for age, sex, education level, glucose metabolism status, lifestyle, cardiovascular risk factors, resting SBP and cardiorespiratory fitness.

Conclusion: A higher exercise SBP response is associated with a higher incidence of clinically relevant depressive symptoms.

Copyright

© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

TY  - JOUR
AU  - Tan Lai Zhou
AU  - Abraham Kroon
AU  - Ronald Henry
AU  - Annemarie Koster
AU  - Pieter Dagnelie
AU  - Hans Bosma
AU  - Marleen van Greevenbroek
AU  - Carla van der Kallen
AU  - Casper Schalkwijk
AU  - Anke Wesselius
AU  - Koen Reesink
AU  - Sebastian Köhler
AU  - Miranda Schram
AU  - Coen Stehouwer
AU  - Thomas van Sloten
PY  - 2020
DA  - 2020/02/15
TI  - 3.7 Exercise Systolic Blood Pressure Response And Incident Depressive Symptoms – The Maastricht Study
JO  - Artery Research
SP  - S28
EP  - S28
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.020
DO  - 10.2991/artres.k.191224.020
ID  - Zhou2020
ER  -