Artery Research

Volume 25, Issue Supplement 1, December 2019, Pages S28 - S28

3.7 Exercise Systolic Blood Pressure Response And Incident Depressive Symptoms – The Maastricht Study

Authors
Tan Lai Zhou1, 2, *, Abraham Kroon1, 2, Ronald Henry1, 2, Annemarie Koster3, 4, Pieter Dagnelie1, 2, Hans Bosma3, 4, Marleen van Greevenbroek4, 2, Carla van der Kallen4, 2, Casper Schalkwijk4, 2, Anke Wesselius4, Koen Reesink2, 4, Sebastian Köhler5, 6, Miranda Schram1, 2, Coen Stehouwer1, 2, Thomas van Sloten1, 2, 7, 8
1Maastricht University Medical Centre, Maastricht, The Netherlands
2CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands
3CAPHRI Care and Public Health Research Institute, Maastricht, The Netherlands
4Maastricht University, Maastricht, The Netherlands
5Alzheimer Centre Limburg, Maastricht University Medical Centre, Maastricht, The Netherlands
6MHeNs School for Mental Health and Neuroscience, Maastricht, The Netherlands
7Université Paris Descartes, Paris, France
8INSERM Paris Cardiovascular Research Centre, Paris, France
*Corresponding author. Email: tanlai.zhou@mumc.nl
Corresponding Author
Tan Lai Zhou
Available Online 15 February 2020.
DOI
10.2991/artres.k.191224.020How to use a DOI?
Abstract

Background: Exaggerated exercise systolic blood pressure (SBP) is a modifiable risk factor associated with vascular dysfunction. Vascular dysfunction may contribute to the development of late-life depression, but the association between exercise SBP and incident depressive symptoms is unknown. Therefore, we investigated whether an exaggerated exercise SBP is associated with a higher risk of depressive symptoms over time.

Methods: Longitudinal data from the population-based Maastricht Study, with only individuals free of depressive symptoms at baseline included (n = 2,121; 51.3% men; age 59.5 ± 8.5 years). Exercise SBP was measured at baseline with a submaximal exercise cycle test. We calculated a composite score of exercise SBP based on 4 standardized exercise SBP measures: SBP at moderate workload, SBP at peak exercise, SBP change per minute during exercise and SBP 4 minutes after exercise. Clinically relevant depressive symptoms were determined annually at follow-up and defined as a Patient Health Questionnaire score of > = 10.

Results: After a mean follow-up of 3.9 years, 175 participants (8.3%) had incident clinically relevant depressive symptoms. A1 standard deviation higher exercise SBP composite score was associated with a higher incidence of clinically relevant depressive symptoms (hazard ratio: 1.27 [95% confidence interval: 1.04–1.54]). Results were adjusted for age, sex, education level, glucose metabolism status, lifestyle, cardiovascular risk factors, resting SBP and cardiorespiratory fitness.

Conclusion: A higher exercise SBP response is associated with a higher incidence of clinically relevant depressive symptoms.

Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Journal
Artery Research
Volume-Issue
25 - Supplement 1
Pages
S28 - S28
Publication Date
2020/02/15
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.191224.020How to use a DOI?
Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Tan Lai Zhou
AU  - Abraham Kroon
AU  - Ronald Henry
AU  - Annemarie Koster
AU  - Pieter Dagnelie
AU  - Hans Bosma
AU  - Marleen van Greevenbroek
AU  - Carla van der Kallen
AU  - Casper Schalkwijk
AU  - Anke Wesselius
AU  - Koen Reesink
AU  - Sebastian Köhler
AU  - Miranda Schram
AU  - Coen Stehouwer
AU  - Thomas van Sloten
PY  - 2020
DA  - 2020/02/15
TI  - 3.7 Exercise Systolic Blood Pressure Response And Incident Depressive Symptoms – The Maastricht Study
JO  - Artery Research
SP  - S28
EP  - S28
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.020
DO  - 10.2991/artres.k.191224.020
ID  - Zhou2020
ER  -