Volume 25, Issue Supplement 1, December 2019
Chloe Park, Alicja Rapala, Siana Jones, Suzanne Williams, Nish Chaturvedi, Alun Hughes
Pages: S1 - S1
Introduction: In adults, aging is associated with a rise in blood pressure (BP) and a disproportionate increase in central systolic blood pressure (cSBP) relative to brachial SBP (bSBP) (i.e. reduced aortic to radial pulse pressure amplification (PPamp)). But changes in brachial and central BP have not...
2. 1.2 Chronological Versus Vascular Age: Predictive Value for Cardiovascular Events and Identification of Patients with SUPERNOrmal Vascular Aging (SUPERNOVA)
Rosa Maria Bruno, Peter Nilsson, Gunnar Ensgrtom, Benjamin Wadstrom, Jean-Philippe Empana, Pierre Boutouyrie, Stephane Laurent
Pages: S2 - S2
Background: Individuals whose arteries appears abnormally healthy in comparison to their CV risk factor burden (supernormal vascular aging, SUPERNOVA) represent an ideal model to discover novel pathways of cardiovascular protection. Purpose: 1) to introduce a novel definition of vascular age, as predicted...
3. 1.4 Prognostic Relevance of Augmentation Index in Prevalent Cardiovascular Disease and Total Mortality: Data From the General Population
Natalie Arnold, Tommaso Gori, Anika Gündling, Andreas Schulz, Jürgen H. Prochaska, Marina Panova-Noeva, Irene M. Schmidtmann, Norbert Pfeiffer, Manfred Beutel, Karl J. Lackner, Thomas Münzel, Philipp S Wild
Pages: S3 - S3
Objectives: To investigate the role of peripheral augmentation index (AIx) for the prediction of prevalent cardiovascular disease (CVD) and total mortality in the general population in age- and sex- specific manner. Methods: AIx was measured in 11,250 participants of the population-based Gutenberg Health...
4. 1.5 Age and Sex Differences in the Association of Brachial and Central Blood Pressure Variability with Arterial Stiffness
Shikai Yu, Kathleen Connolly, Spoorthy Kulkarni, Viknesh Selvarajah, Jean Woodcock-Smith, Ian Wilkinson, Carmel McEniery
Pages: S4 - S5
Background: Both blood pressure variability (BPV) and arterial stiffness (AS) are significantly influenced by age and sex. However, whether the association between BPV and AS differs with age and sex remains unclear. We examined age and sex differences in the association between brachial and central...
5. 1.6 Individual and Neighborhood Deprivation and Carotid Stiffness: The Paris Prospective III Study
Rachel Climie, Pierre Boutouyrie, Marie-Cecile Perier, Catherine Guibout, Thomas van Slotten, Frederique Thomas, Nicolas Danchin, James Sharman, Stephane Laurent, Xavier Jouven, Jean-Philippe Empana
Pages: S6 - S6
Background: Large artery stiffness is an index of vascular ageing associated with cardiovascular mortality. While traditional risk factors for arterial stiffness are known, the contribution of socioeconomic factors are less reported. We sought to determine the relationship between arterial stiffness...
6. 2.1 Derivation of Central Aortic Pressure Using the Radial Pulse Waveform Acquired by Millimetre-Wave Radar
Ahmad Qasem, Oliver Shay, Catherine Liao, Mark Butlin, Alberto Avolio
Pages: S7 - S7
A new wearable sensor using millimetre-wave radar and electromagnetic technology provides 64 signals reflected from one radar sinusoidal signal beamed around the radial artery. It is non-invasive, can be non-contact, and is potentially simpler in acquiring the radial pulse then tonometry. This study...
7. 2.2 Modest Region-Specific, Sex-Independent Aortic Remodelling when Hypertension is Superimposed on Aging
Bart Spronck, Jacopo Ferruzzi, Alexander W. Caulk, Sae-Il Murtada, Jay D. Humphrey
Pages: S8 - S9
Background: Aging and hypertension often co-occur, which complicates distinguishing their biomechanical effects on arteries clinically. While aortic elastin (half-life ~70 years) is reduced in human aging, in mouse aging (lifespan ~2 years) it remains mostly intact. Knock-out of elastin-associated glycoprotein...
8. 2.3 Exosomes Derived From Endothelial Progenitor Cells Modulate Flow-Induced Remodeling and Increase Vasculogeneis in Mesenteric Arteries of Mice
Joaquim Bobi, Emilie Vessieres, Linda Grimaud, Manel Sabate, Daniel Henrion, Ana Paula Dantas
Pages: S10 - S10
Exosomes are key regulators of cell-to-cell communication, becoming valuable tool as disease biomarker and in the development of new therapeutic strategies. We aimed to determine the role of endothelial progenitor cell (EPC)-derived exosomes (EXO) in vascular remodelling induced by flow. C57BL/6 mice...
9. 2.4 Aortofemoral Plethysmographic Volume Wave Velocity Obtained During the Routine 12 Channel ECG Corresponds in its Determinants to Tonometrically Derived Carotid-Femoral Pulse Wave Velocity
Falko Skrabal, Thomas Weber, Katharina Skrabal
Pages: S11 - S12
Background: The lack of acceptance in clinical routine represents a major obstacle for carotid-femoral pulse wave velocity (cfPWV) measurements. We thought to include PWV measurements into the 12-channel ECG, which is performed routinely. Methods: Using the conventional electrode position for the 12...
10. 2.5 Differential Association of Central and Peripheral Arterial Compliance with Resting and Recruitable Endothelial Function in Healthy Human Subjects
Smriti Badhwar, Dinu Chandran, Ashok Jaryal, Rajiv Narang, Chetan Patel, Kishore Kumar Deepak
Pages: S13 - S14
Background: Regional arterial compliance in peripheral arteries is known to be associated with ‘recruitable’ endothelial function probably mediated by an increase in smooth muscle tone . However, the association between regional arterial stiffness and ‘resting’ endothelial function has not been evaluated. Methods:...
Louise Marais, Hakim Khettab, Yanlu Li, Patrick Segers, Roel Baets, Koen Reesink, Soren Aasmul, Mirko De Melis, Pierre Boutouyrie
Pages: S15 - S15
Purpose: There is a need for new tools to screen large populations for cardiovascular disease risk. The CARDIS consortium (European Union H2020 funding) developed an easy-to-use, non-contact device for measuring carotid to femoral pulse wave velocity (cfPWV). It consists in a laser doppler vibrometer...
12. 2.7 Machine Learning on Central Hemodynamic Quantities Using Noninvasive Measurements: How Far Can We Go?
Vasiliki Bikia, Stamatia Pagoulatou, Nikolaos Stergiopulos
Pages: S16 - S18
Background: Transforming peripheral noninvasive measurements to obtain central hemodynamic quantities, such as cardiac output (CO) and central systolic blood pressure (cSBP), is a highly emerging field [1,2]. However, no holistic investigation has been performed to assess the amount of information contained...
13. 2.8 Unique patterns of elastin degradation in ascending aortic aneurysms in bicuspid aortic valve patients
Ya Hua Chim, Hannah Davies, Omar Nawaytou, Mark Field, Jillian Madine, Riaz Akhtar
Pages: S19 - S19
Background: Bicuspid aortic valve patients (BAV) are associated with increased risk of ascending aortic aneurysms. However, is unclear whether matrix degradation varies in different ascending aneurysm aetiologies. Aim: To determine whether the micromechanical and biochemical properties elastin microstructure...
14. 3.1 Why Flow Mediated Dilation Fails to Assess True Endothelial Cell Function? A Computational Based Investigation
Weiwei Jin, Jordi Alastruey, Phil Chowienczyk
Pages: S20 - S20
Objective and Motivation: Endothelial dysfunction is thought to underpin atherosclerotic cardiovascular diseases. However, the widely used flow mediated dilation (FMD) in-vivotest of endothelial function relates poorly to clinical outcomes. In this study, we investigated potential confounding factors...
15. 3.2 First Genome-Wide Association Study of Cardiovascular Magnetic Resonance Derived Aortic Distensibility Reveals 7 Loci
Kenneth Fung, Luca Biasiolli, Evan Hann, Julia Ramirez, Elena Lukaschuk, Nay Aung, Jose Paiva, Konrad Werys, Mihir Sanghvi, Ross Thomson, Jennifer Rayner, Henrike Puchta, Niall Moon, Katharine Thomas, Aaron Lee, Stefan Piechnik, Stefan Neubauer, Steffen Petersen, Patricia Munroe
Pages: S21 - S22
Background: Although arterial stiffness has demonstrated moderate heritability, our knowledge of the genes modulating arterial stiffness is still limited. We conducted genome-wide association studies (GWASs) of aortic distensibility (AoD) in both ascending (AA) and proximal descending aorta (PDA) to...
16. 3.3 Age- and sex-specific reference intervals for brachial artery flow-mediated dilation in healthy individuals and the relation with cardiovascular risk factors
Sophie Holder, Rosa Maria Bruno, Daria Shkredova, Andrew Thompson, Ellen Dawson, Helen Jones, Nicola Hopkins, Maria Hopman, Tom Bailey, Jeff Coombes, Christopher Askew, Louise Naylor, Andrew Maiorana, Lorenzo Ghiadoni, Daniel Green, Dick Thijssen
Pages: S23 - S23
Background: Assessment of endothelial function using brachial artery flow-mediated dilation (FMD) predicts future cardiovascular disease (CVD) risk. However, poor adherence to protocol guidelines and lack of reference values hinders widespread FMD use. This study established age- and sex-specific reference...
Antonio Gallo, Etienne Charpentier, Thomas Dietenbeck, Antoine Dufay, Alban Redheuil, Marie Chupin, Olivier Hanon, Xavier Girerd, Nadjia Kachenoura
Pages: S24 - S24
Background: Cerebral microvascular alterations and hypoperfusion have been associated to cognitive disorder and dementia. We hypothesized that there is a direct link between retinal arteriolar remodelling, as assessed non-invasively using adaptive optics, and cognitive cerebral impairment in hypertensive...
18. 3.5 Arterial Stiffness Partly Explains Sex Differences in Associations Between Left Ventricular Structure and Mortality: The Southall and Brent Revisited (Sabre) Study
Lamia Al Saikhan, Chloe Park, Therese Tillin, Jamil Mayet, Nish Chaturvedi, Alun Hughes
Pages: S25 - S26
Background: We have previously shown that 3D echocardiography-derived (3DE) indices of left ventricular (LV) structure predict all-cause mortality differently in men and women . However, the mechanism behind these sex differences remains unknown. We therefore examined the role of macro- and micro-vascular...
Zhengzheng Huang, Chloe Park, Nishi Chaturvedi, Laura Howe, James Sharman, Alun Hughes, Martin Schultz
Pages: S27 - S27
Objective: Exaggerated exercise blood pressure (BP) is associated with cardiovascular risk factors in adolescence. Aerobic fitness and adiposity (fat mass or ‘fatness’) are important independent contributors to cardiovascular risk in adolescence, but their interrelated associations with exercise BP are...
20. 3.7 Exercise Systolic Blood Pressure Response And Incident Depressive Symptoms – The Maastricht Study
Tan Lai Zhou, Abraham Kroon, Ronald Henry, Annemarie Koster, Pieter Dagnelie, Hans Bosma, Marleen van Greevenbroek, Carla van der Kallen, Casper Schalkwijk, Anke Wesselius, Koen Reesink, Sebastian Köhler, Miranda Schram, Coen Stehouwer, Thomas van Sloten
Pages: S28 - S28
Background: Exaggerated exercise systolic blood pressure (SBP) is a modifiable risk factor associated with vascular dysfunction. Vascular dysfunction may contribute to the development of late-life depression, but the association between exercise SBP and incident depressive symptoms is unknown. Therefore,...
21. 3.8 The importance of micro-and macrocirculation indices implementation for the amelioration of cardiovascular risk classification
Triantafyllou Areti, Dipla Konstantina, Koletsos Nikolaos, Gkaliagkousi Eugenia, Lazaridis Antonios, Zafeiridis Andreas, Douma Stella
Pages: S29 - S29
Recently, many promising indices of micro- and macrocirculation have been widely used to promptly detect target organ damage before major cardiovascular events occur. More specifically, nailfold capillaroscopy, fundoscopy, near-infrared spectroscopy, ultrasound, laser speckle contrast analysis and central...
22. 4.1 Hypertension is Associated with Adverse Cardiovascular Outcomes only when Both Brachial and Central Blood Pressures are Elevated
Remi Goupil, Florence Lamarche, Mohsen Agharazii, François Madore
Pages: S30 - S30
Background: The range of central blood pressure (BP) found in individuals with high-normal brachial BP overlaps the one found in hypertension (HTN) and normotension. As central BP is possibly a better predictor of cardiovascular (CV) disease, the aim of this study was to determine the risk associated...
Wesley Lefferts, Jacob DeBlois, Jacqueline Augustine, Allison Keller, Kevin Heffernan
Pages: S31 - S31
Cerebral pulsatility is an emerging contributor to brain health that reflects the balance between the transmission and damping (i.e. attenuation) of pulsatility through extracranial vessels into the cerebrovasculature. Identifying biological (age, sex) and vascular contributors to pulsatile balance may...
24. 4.3 Aortic Pulse Wave Velocity Measured by Occlusive, Suprasystolic, Oscillometric Method (Arteriograph) Independently Predicts all Cause Mortality
Pages: S32 - S32
Introduction: It has been long debated whether Arteriograph predicts cardiovascular events and/or all cause mortality, despite that its prognostic value has been proven in systolic heart failure and in myocardial infarction already. However, no data were available about the prognostic value of this method...
Luca Faconti, Bushra Farukh, Ryan McNally, Andrew Webb, Phil Chowienczyk
Pages: S33 - S33
Background: Effects of short-term interventions on large artery stiffness assessed by pulse wave velocity (PWV) have mainly been explained by concomitant changes in blood pressure (BP). However, lower body negative pressure (LBNP), which increases sympathetic activity (SA) has a specific effect on PWV...
26. 4.5 Increased Central Pulse Pressure in Children Results From Increased Early Ejection Velocity and Increased Aortic Pulse Wave Velocity
Ye Li, Haotian Gu, Manish Sinha, Phil Chowienczyk
Pages: S34 - S34
Introduction: The aim of the present study was to examine the contribution of left ventricular ejection, arterial stiffness and systemic vascular resistance to essential hypertension in children with hypertension. Methods: A total of 81 children aged 7 to 18 years (mean age 14 years) including 31 with...
27. 4.6 Effects of Combined Therapy of Empagliflozin and Linagliptin Versus Metformin and Insulin Glargine on Blood Pressure and Vascular Function in Patients with Type 2 Diabetes
Christian Ott, Susanne Jung, Agnes Bosch, Dennis Kannenkeril, Kristina Striepe, Roland Schmieder
Pages: S35 - S35
Background: Combination of insulin with oral antidiabetic drugs is a valid option, but oral combination therapy emerged as an alternative treatment in type 2 diabetes (T2DM). However, the effects on blood pressure (BP) and vascular function of such combination therapies is less clear. Methods: In this...
28. 4.8 Reference Values for Submaximal Exercise Blood Pressure: the EXERcise Stress Test CollaboratION (EXERTION)
Schultz Martin, Ann-Marie Kovacevic, Philip Roberts-Thomson, Tony Stanton, Christian Hamilton-Craig, Sudir Wahi, James Hare, Joseph Selvanayagam, Andrew Maiorana, Alison Venn, James Sharman
Pages: S36 - S36
Background: Exaggerated blood pressure (BP) during submaximal exercise independently predicts cardiovascular mortality and identifies uncontrolled high BP not detected at rest. However, thresholds for submaximal exercise BP during clinical exercise testing have never been defined from a large representative...
29. 5.1 The Role of Blood Pressure, Aortic Stiffness, and Haemodynamics in Brain Health in Older People with Type 2 Diabetes Mellitus
Christopher Karayiannis, Chris Moran, Richard Beare, James Sharman, Thanh Phan, Amanda Thrift, Wei Wang, Velandai Srikanth
Pages: S37 - S37
Aims: Type 2 diabetes (T2D) is associated with dementia, and abnormal blood pressure (BP), aortic stiffness, and haemodynamics. We aimed to study the contribution of such factors to brain structure and cognition, relative to the contribution of metabolic factors in T2D such as insulin resistance and...
Christelle Darnaud, Alexandre Courtet, Audrey Schmitt, Clotilde Carra, Pierre Boutouyrie, Philippe Bouchard
Pages: S38 - S38
Background: Despite a large number of studies linking cardiovascular diseases and periodontitis (Buhlin et al. 2011; Hansen et al. 2016; Pussinen et al. 2003), few studies make it possible to draw accurate conclusions on the link between periodontitis and arterial stiffness. Endothelial cells maintain...
Shikai Yu, Barry McDonnell, Kaisa Maki-Petaja, John Cockcroft, Ian Wilkinson, Carmel McEniery
Pages: S39 - S39
Background: In young adults, systolic blood pressure (SBP) and hypertension rates are significantly lower in females than males, although the extent to which this is due to differences in body size (body surface area; BSA) is unclear. Cardiac output (CO), a key haemodynamic determinant of SBP in young...
32. 5.4 Acute Effects of Indapamide Treatment on Haemodynamics and Glycosaminoglycan-Mediated Non-Osmotic Skin Sodium Storage in Healthy Humans
Kathleen Connolly, Viknesh Selvarajah, Carmel McEniery, Ian Wilkinson
Pages: S40 - S40
Introduction: The skin may protect against the adverse haemodynamic effects of dietary salt by storing excess sodium in an osmotically inactive form, bound to glycosaminoglycans. However, this novel pathway has not been comprehensively studied in humans. Methods: 85 healthy volunteers (37 m, 48 f) <50...
33. 5.5 A Femoral ‘Stealing’ Effect: Presence of Collateral Retrograde Blood Flow Redistribution in the Femoral Bifurcation During Reactive Hyperemia
Jason Au, Robert Amelard, Billy Yiu, Hassan Nahas, Richard Hughson, Alfred Yu
Pages: S41 - S41
Background & Purpose: The femoral bifurcation houses complex flow recirculation that may be impacted by downstream peripheral resistance; however, conventional ultrasound is unable to quantify multi-directional flow to study these phenomena. The purpose of this study was to examine the multi-directional...
34. 5.6 Aortic Pressure Behind Flow Disorganization in Aneurismal Aorta: a Magnetic Resonance Imaging Study
Kevin Bouaou, Thomas Dietenbeck, Gilles Soulat, Sophia Houriez—Gombaud-Saintonge, Ioannis Bargiotas, Alain De Cesare, Umit Gencer, Alain Giron, Alban Redheuil, Emilie Bollache, Didier Lucor, Elie Mousseaux, Nadjia Kachenoura
Pages: S42 - S42
Purpose: Understanding and prediction of ascending thoracic aortic aneurysms (ATAA) progression are not well established yet and aortic dissection is frequently occurring on normally sized and mildly dilated aortas. Despite known theoretical associations between pressures and blood flow patterns there...
Phakakorn Panpho, Hannah Davies, Mark Field, Jillian Madine, Ying Yang, Riaz Akhtar
Pages: S43 - S43
Background: Aortic dissection is a devastating condition, beginning with a tear through from intima to the medial layer, leading to splitting of aortic layers and creating the false and true lumen with a septum (or flap). Little is known about the properties of the dissection flap. Aim: To determine...
Gergő Szanda, Éva Wisniewski, Anikó Rajki, András Spät
Pages: S44 - S44
Elevation of plasma [K+] and [angiotensin II] (Ang II), two major physiological stimuli of adrenal zona glomerulosa cells, increase aldosterone production by triggering cytosolic Ca2+ signalling. Cytosolic Ca2+ signals are accompanied by mitochondrial Ca2+ elevations which further strengthen this steroidogenic...
37. P3 Factor Influencing Endothelial Function in Type 2 Diabetes Mellitus with Newly Diagnosed Hypertension
Pages: S45 - S45
Background: Increased risk for cardiovascular diseases is associated with diabetes, can be partially attributed to endothelial dysfunction. However, the cumulative factors leading to endothelial dysfunction in Type 2 DM are not clear. In the current study, a novel attempt was made to understand factors...
38. P4 Aldosterone-Induced Vascular Dysfunction by Decreasing Nuclear Factor Erythroid 2–Related Factor 2 Activity and Increasing Reactive Oxygen Species Generation
Daniel Rodrigues, Tiago Januário da Costa, Rafael Menezes da Costa, Rita de Cássia Aleixo Tostes Passaglia
Pages: S46 - S46
Introduction: Chronic increases in aldosterone (Aldo) levels (hyperaldosteronism) increases blood pressure and induces hypertension. In the cardiovascular system, Aldo stimulates reactive oxygen species (ROS) generation. ROS contribute to vascular dysfunction by increasing vascular smooth muscle contractile...
39. P5 Aortic Volume Wave Velocity (VWV) in Chronic Heart Failure (CHF) Measured During the 12 Channel Routine ECG by Impedance Plethysmography Relates Negatively to Appendicular Muscle Mass (AppMM)
Falko Skrabal, Johannes Boyer, Hasib Ehsas, Katharina Skrabal
Pages: S47 - S47
Introduction: Pulse wave velocity or (or VWV) may relate to muscle mass and body fat. We have included measurements for the above in the routine 12 channel ECG. Methods: A 12 channel ECG supplies impedance plethysmographic measurements at the four extremities at 40 kHz . From these VWW was derived...
Serrano Andreia, Casal Diogo, O’Neill João Goyri, Vassilenko Valentina
Pages: S48 - S48
The knowledge about the required quantity of blood to irrigate an angiosome is important on ischemia (disruption on blood perfusion) prediction, diagnosis and treatment. An angiosome (or flap) is an anatomic unity (or flap) of tissue, it is constituted by skin, subcutaneous tissue and muscle, it is irrigated...
41. P7 Assessing Vascular Age from Peripheral Pulse Waves: a Study of Existing Indices, and Directions for Future Research
Peter Charlton, Maria Aresu, Jeanette Spear, Phil Chowienczyk, Jordi Alastruey
Pages: S49 - S49
Purpose: Vascular age may be a better marker of cardiovascular risk than age. It has been proposed that vascular age could be assessed easily and inexpensively from the photoplethysmogram (PPG) pulse wave, which is measured by pulse oximeters and fitness bands. Our aim was to assess the performance of...
42. P8 O-GlcNAcylation Increases Constriction in Common Carotid Artery of Senescent-Accelerated Female Mice
Tiago J. Costa, Josiane F. Silva, Renée de Nazaré O. da Silva, Paula R. Barros, Juliana Bolsoni, Daniel Rodrigues, Eliana H. Akamine, Rita Tostes
Pages: S50 - S50
The glycosylation with O-linked-N-acetylglucosamine (O-GlcNAc) is an enzymatic process found on nuclear and cytoplasmic proteins. Augmented levels of O-GlcNAc-modified proteins have been associated to cardiovascular disease (CD) in male. However, the association of O-GlcNAc and CD in females it’s not...
43. P9 Repeatability and Predictors of a Potentially Blood Pressure-Independent Parameter of Arterial Stiffness
Mark Butlin, James Cox, Bart Spronck, Isabella Tan, Alberto Avolio
Pages: S51 - S51
Background: Arterial stiffness (e.g., as measured by carotid-femoral pulse wave velocity (cfPWV)) changes acutely with blood pressure (BP). High cfPWV at high BP could be due to structural arterial changes or acute BP effects. Various parameters have been proposed as BP-independent parameters of arterial...
44. P10 Oscillatory Flow Patterns in Peripheral Conduit Artery are Related to Central Arterial Stiffness in Healthy Subjects
Smriti Badhwar, Dinu Chandran, Ashok Jaryal, Rajiv Narang, Chetan Patel, Kishore Kumar Deepak
Pages: S52 - S53
Background: Studies in endothelial cell cultures show that oscillating flow pattern leads to endothelial dysfunction . The only factor known to contribute towards oscillatory flows is peripheral arterial conductance . However, contribution of alterations in central arterial properties to oscillatory...
Alexandre Raoul, Ekaterina Belozertseva, Huguette Louis, Zhenlin Li, Veronique Regnault, Patrick Lacolley
Pages: S54 - S54
It has been demonstrated that arterial stiffness is linked to arterial fibrosis manifested by increased collagen and other extracellular matrix synthesis in smooth muscle cells (SMC). Transmembrane receptors integrins mediating cell-cell and cell-matrix signalling pathways are involved in tissue fibrosis....
46. P12 Proliferation and Procoagulant Activity of Vascular Smooth Muscle Cells from Thoracic and Abdominal Aortic Aneurysms
Melusine Didelot, Jeremy Lagrange, Jean-Baptiste Michel, Patrick Lacolley, Veronique Regnault
Pages: S55 - S55
In contrast to abdominal aortic aneurysm (AAA), aneurysms of the thoracic ascending aorta (TAA) are not associated with a mural thrombus. Mechanistic understanding of the involvement of vascular smooth muscle cells (VSMCs) in thrombus formation is lacking. We aim to determine (i) whether thrombin generation...
Joana Ferreira, Pedro Cunha, Alexandre Carneiro, Cristina Cunha, Cristina Silva, Isabel Vila, Amílcar Mesquita, Jorge Cotter
Pages: S56 - S56
Background: Peripheral arterial disease (PAD) is a manifestation of atherosclerosis. Adipose tissue (AT) and skeletal muscle (SM) are endocrine organs with vascular effects. The objective is to compare the quantity and function of AT and SM between two groups: intermittent claudication (IC) and critical...
48. P15 Reference Intervals of 24-hour Central Blood Pressure Assessed with an Oscillometric Device in Healthy Children and Adolescents
Igor Posokhov, Alexandr Sharykin, Inna Trunina
Pages: S57 - S58
Reference intervals (RI) of 24-h central blood pressure (24CBP) obtained from large healthy population are lacking in Russia. We had to generated 24CBP percentile curves and RI adjusted to each level of age and/or body height and gender of each time of monitoring (24-h, daytime or nighttime). Our database...
49. P16 Assessment of Plaque Vulnerability Using a Novel Technique: Multi-spectral Photoacoustic Imaging (CVENT-PAI)
Yuki Imaizumi, Hasan Obeid, Pierre Julia, David Calvet, Pierre Boutouyrie
Pages: S59 - S59
Background: Identification of intraplaque haemorrhage using magnetic resonance imaging (MRI) is expensive, technically demanding and sometimes uncomfortable. Photoacoustic imaging (PAI) is a new non-invasive technique combining multi-wavelength infrared laser light and ultrasound (US) imaging, able to...
50. P17 Comparisons of Carotid-femoral Pulse Wave Velocity Obtained from the Surface-distance Measurement and from the Population-derived Distance Formula: Associations with Macro- and Microvascular Alterations in Older Adults
Kunihiko Aizawa, Francesco Casanova, Dave Mawson, Kim Gooding, Salim Elyas, Damilola Adingupu, David Strain, Phillip Gates, Angela Shore
Pages: S60 - S60
Introduction: Inaccurate determination of arterial path-length by surface-distance (SD) measurement is an inherent source of error in calculating carotid-femoral pulse wave velocity (CFPWV). A recent development in calculating arterial path-length by a simple distance formula (DF) for CFPWV has been...
51. P18 Vascular Aging Index of the Finger Photoplethysmogram: A Validation Study with Vascular Stiffness, Mental Stress, and Day-to-Day Variability
Takashi Tarumi, Takayuki Yamabe, Jun Sugawara
Pages: S61 - S61
Background: Daily assessment of vascular health may predict cardiovascular incidence. Vascular aging index (VAI) calculated from second derivative of photoplethysmogram (SDPTG) is a simple, non-invasive measure possibly reflecting vascular stiffness. However, the effects of daily life events such as...
52. P19 Upper Arm Cuff Inflation Induces Reactive Changes in Systolic Blood Pressure that Could Influence Diagnosis in Some Individuals
Louisa Morris, Dean Picone, Matthew Armstrong, Martin Schultz, James Sharman
Pages: S62 - S62
Introduction: Clinic blood pressure (BP) is performed by inflation of an upper-arm cuff, but this itself may induce a reactive change in BP that could influence diagnosis. This study aimed to determine if a reactive BP change to cuff inflation occurs. Methods: Cuff BP and beat-to-beat invasive aortic...
Blanka Varnai, Gábor Simonyi, Andrea Rapcsányi, Ervin Finta
Pages: S63 - S63
Objectives: The occlusion of the internal carotid artery (ICA) frequently leads to stroke and develops most commonly as a consequence of arterial embolism or atherosclerotic thrombosis. Following acute care, if the patient’s general condition makes it possible, the patient is emitted from the hospital...
54. P21 The Association of Vitamin K Antagonists with Aortic Arch Calcification in Acute Coronary Syndrome Patients
Konstantia-Paraskevi Gkini, Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Aggeliki Rigatou, Vasiliki Gardikioti, Evangelia Sigala, Dimitrios Tousoulis
Pages: S64 - S64
Purpose /Background /Objectives: Vitamin K antagonists (VKA) aggravate vascular calcifications burden, especially in haemodialysis patients potentially compounding their cardiovascular risk. We sought to investigate the relationship between VKA intake and aortic arch calcification (AAC) in patients with...
55. P22 Central and Peripheral Contributions to Submaximal Exercise Performance in Older Adults in the SouthAll and Brent REvisited (SABRE) Study
Siana Jones, Martin Schultz, Therese Tillin, Suzanne Williams, Nishi Chaturvedi, Alun Hughes
Pages: S65 - S65
Background: Functional capacity declines with age leading to disability and increased cost of health and social care. In older adults, factors that influence the ability to sustain sub-maximal exercise (a marker of functional capacity) are not well defined. We aimed to determine the contribution of cardiac...
56. P23 Tadalafil improves hemodynamic parameters and arterial stiffness in patients with grade I-II obesity without comorbidities
Mariana Larios-Cardenas, Fernando Grover-Páez, David Cardona-Muller, Ernesto Cardona, Oscar I. Gonzalez-Radillo, Jonathan Trujillo-Quiros, Marycruz Barocio-Pantoja, Patricia Quezada-Fernandez, Carlos G. Ramos-Becerra
Pages: S66 - S66
Background: Obesity is a global health problem, it is associated with diabetes, hypertension, and cardiovascular diseases  and negative hemodynamic effects have been observed . Tadalafil has shown an improvement in endothelial function  the aim of the present investigation was to evaluate its...
57. P24 Restored Physiological Local Carotid Pulse Wave Velocity After Bariatric Surgery in Obese Subjects
Alessandro Giudici, Carmela Morizzo, Michaela Kozakova, Lorenzo Losso, Carlo Palombo, Kennedy J. Cruickshank, Ashraf Khir
Pages: S67 - S67
Obesity is a risk factor for cardiovascular events and is associated with increased arterial stiffness [1,2]. However, the effect of drastic changes in Body Mass Index (BMI) on arterial mechanics has not been fully investigated. Our study aimed at evaluating changes in local carotid PWV (cPWV) in obese...
Brooks Hibner, Elizabeth Schroeder, Wesley Lefferts, Thessa Hilgenkamp, Huimin Yan, Gavin Horn, Denise Smith, Bo Fernhall
Pages: S68 - S68
Introduction: Cardiovascular events are the leading cause of death among firefighters, with the greatest risk occurring during or shortly after fire suppression activity. Increased cardiovascular risk potentially manifests from detrimental changes in ventricular function, vascular load, and their interaction...
Andrea Guala, Lydia Dux-Santoy, Gisela Teixido-Tura, Aroa Ruiz-Muñoz, Laura Madrenas, Minerva Gandara, Augusto Sao-Aviles, Filipa Valente, Laura Galian-Gay, Laura Gutierrez, Teresa Gonzalez-Alujas, Ignacio Ferreira, Arturo Evangelista, Jose Rodriguez-Palomares
Pages: S69 - S69
Background: Impaired ascending aorta (AAo) longitudinal strain, a marker of AAo deformation due to aorto-ventricular mechanical interaction, is related to progressive dilation and aortic events in Marfan syndrome . Whether the high prevalence of dilation in bicuspid aortic valve (BAV) is due to intrinsically-altered...
60. P27 Non-validated Blood Pressure Devices Dominate the Online Marketplace: An Initiative of the Lancet Commission on Hypertension Group
Dean Picone, Rewati Deshpande, Martin Schultz, Ricardo Fonseca, Norm Campbell, Christian Delles, Michael Hecht-Olsen, Aletta Schutte, George Stergiou, Sonia Angell, Raj Padwal, James Sharman
Pages: S70 - S70
Introduction: Home BP monitoring is recommended to guide clinical decisions on hypertension and is used worldwide. People make their own decisions when purchasing BP measurement devices, which are often made online. One potential barrier to accurate home BP monitoring is that patients may purchase an...
61. P28 A Commonly Used Single-item Physical Activity Question Fails to Discriminate Expected Blood Pressure-related Cardiovascular Risk in a General Community Sample
Martin Schultz, Dean Picone, Ricardo Fonseca, James Sharman
Pages: S71 - S71
Background: Completion of ≥150 minutes/week of physical activity (PA) is recommended for cardiovascular health, but this is achieved only by ~50% of Australian adults. Assessing self-reported PA via quick single-item question is desirable for large-scale cardiovascular research and health screening....
62. P30 Interplay of Genetic and Environmental Factors Determining Carotid and Femoral Intima-media Thickness and Plaques
Adam Domonkos Tarnoki, Rebeka Debreceni, Greta Janositz, Kata Gyulay, Jokkel Zsofia, Viktor Berczi, Helga Szabo, Anita Hernyes, David Laszlo Tarnoki
Pages: S72 - S72
Introduction: Intima-media thickness (IMT) of carotid and femoral artery and plaque formation are both markers of subclinical cardiovascular risk, despite these two process are not simultaneous. Our aim was to investigate their genetic and environmental background. Methods: 54 monozygotic (MZ) and 32...
Johannes Van Rooyen, Lebo Gafane-Matemane, Hugo Huisman, Carina Mels, Alta Schutte
Pages: S73 - S73
Objectives: High levels of aldosterone may contribute to early development of hypertension. The aim was to evaluate the influence of high serum aldosterone on cardiovascular function in healthy black and white South Africans. Methods: This study was embedded in the African-PREDICT study, included 233...
István Barna, Ede Kékes, Gergely Dankovics, Tennó Daiki
Pages: S74 - S74
From 2010 a new, complex screening program started in Hungary, it works with the support of 76 professional-scientific societies and companies. Within the framework of the Program in the largest mobile diagnostics center in Hungary 37 comprehensive surveys in free form. This enormous special screening...
65. P34 24-Hour Ambulatory Brachial Versus Aortic Systolic Blood Pressure: Relationship with Left Ventricular Mass Significantly Differs. Pooled Results from the International 24 Hour Aortic Blood Pressure Consortium (i24ABC)
Siegfried Wassertheurer, Athanase Protogerou, James Sharman, Enrique Rodilla Sala, Piotr Jankowski, Maria Lorenza Muiesan, Cristina Giannattasio, Bernhard Hametner, Jose Maria Pascual, Robert Zweiker, Antonio Argyris, Anna Paini, Ian Wilkinson, Danuta Czarnecka, Massimo Salvetti, Alessandro Maloberti, Carmel McEniery, Yan Li, Janos Nemcsik, Giacomo Pucci, Cornelia Ablasser, Jacques Blacher, Alexandre Valleé, Alejandro de la Sierra, Yi Zhang, Hongwei Ji, Barry McDonnell, Marco Mota, Annelise Paiva, Andrea Brandao, Thomas Weber
Pages: S75 - S75
Background: There is evidence of a closer relation between 24 hour aortic systolic blood pressure (aSBP) and left ventricular mass (LVM) compared with 24 hour brachial SBP. However, sample sizes are relatively small and there is some inconsistency in findings. We sought to address this by pooling data...
66. P35 Education Level may Modify the Association Between Cardiac Index and Cognitive Function Among Elders with Normal Ejection Function
Cheng Hao-Min, Chuang Shao-Yuan, Ko Yu-Ting, Liao Chao-Feng, Pan Wen-Harn, Liu Wen-Ling, Hung Chen-Ying, Chen Chen-Huan
Pages: S76 - S76
Background: Lower cardiac index (CI) in elders without clinical heart disease has been associated with impaired cognitive function and incident dementia. In the present study, we investigated the modulating effects of education level and arterial stiffness on the association between CI and cognitive...
67. P36 Leukocyte Telomere Length is Inversely Associated with Wave Reflection in 566 Normotensive and Never-treated Hypertensive Subjects
Ilkka Pörsti, Milja Honkonen, Kati Vääräniemi, Outi Saijonmaa, Antti Tikkakoski, Jenni Koskela, Arttu Eräranta, Mika Kähönen, Jukka Mustonen, Frej Fyhrquist
Pages: S77 - S77
Background: Telomeres are short segments in chromosome ends, the length of which is reduced during cell life-cycles. We examined the association of leukocyte telomere length and short telomere proportion with hemodynamic variables. Methods: Altogether 566 subjects (279 women and 287 men) without cardiovascular...
Andrii Boguslavskyi, Haotian Gu, Lingyun Fang, Ana Rita Cabrito Cobaco, Philip Chowienczyk
Pages: S78 - S78
Background: Arterial stiffness, as measured by pulse wave velocity (PWV) is dependent on arterial blood pressure but whether this dependence varies with age is unknown. The objective of this study was to determine to what degree pressure-dependence varies with age. Methods: 83 heathy (43 females) normotensive...
69. P38 Association of Daytime Augmentation Index with Brain-derived Neurotrophic Factor in Untreated Hypertensive Patients
János Nemcsik, Dóra Batta, Beáta Kőrösi, Zsófia Nemcsik-Bencze, Andrea László, Lilla Lénárt, Andrea Fekete
Pages: S79 - S79
Brain-derived neurotrophic factor (BDNF) is a neurotrophic molecule with impact on microvasculature and also with complex psychosomatic connections. The aim of our study was to evaluate its associations with 24-hour brachial and central hemodynamic parameters and arterial stiffness in untreated patients...
70. P40 Arteriovenous Fistula, Blood Pressure and Arterial Reservoir-wave Analysis: Lessons From End-stage Renal Disease
Mathilde Paré, Rémi Goupil, Catherine Fortier, Fabrice Mac-Way, Karine Marquis, Bernhard Hametner, Siegfried Wassertheurer, Martin Schultz, James E. Sharman, Mohsen Agharazii
Pages: S80 - S80
Purpose/Background/Objectives: According to reservoir-wave theory, excess pressure (XSP) is analogous to flow and related to excess cardiac workload. In end-stage renal disease (ESRD) patients, we have shown that XSPI is associated with increased mortality and is higher in patients with arteriovenous...
R. M. Böcskei, B. Benczúr, A. Bikov, Cs. Böcskei, A. Bohács, R. Husznai, A. Cziráki
Pages: S81 - S81
Introduction: Chronic obstructive pulmonary disease (COPD) is currently one of the leading causes of death worldwide. COPD frequently occur together with cardiovascular disease. The coexistence of the two diseases are associated with worse outcomes than either condition alone. ABPM and 24 h arterial...
72. P42 Correlation Between Neck Circumference and Pulse Wave Velocity in a Population Based Study in Salvador-Brazil, Preliminary Results
Larissa Bessa, Roberta Cunha, Lucélia Magalhães, Diorlene da Silva, Antônio Filho, Rodrigo Lima, Grupo Vascor
Pages: S82 - S82
Introduction: Pulse wave velocity (PWV) is considered a gold standard for assessment of arterial stiffness ; neck circumference (NC) is a good anthropometrical indicator of fat accumulation in the upper body region . Methods: A population-based cross-sectional study representative of a neighborhood...
73. P43 The Association of Irritable Affective Temperament with 24-Hour Brachial and Central Blood Pressure and Hemodynamic Parameters in Untreated Hypertensive Men
Beáta Kőrösi, Dóra Batta, Milan Vecsey-Nagy, Xenia Gonda, Zoltán Rhimer, Zsófia Nemcsik-Bencze, Andrea László, János Nemcsik
Pages: S83 - S83
Background: Affective temperaments (depressive, irritable, hyperthymic, anxious, cyclothymic) have important role in psychopathology, but cumulating data support their involvement in vascular pathology, especially in hypertension as well. The aim of our study was to evaluate their associations with 24-hour...
Pedro Forcada, Miguel Sangiovanni, Wanda Pampinella, Oscar Montaña
Pages: S84 - S84
Background: High systolic blood pressure in young individuals with normal central pressure has been described as “Spureous Systolic Hypertension” and there is a strong controversy if it is a normal or pathologic condition. Objective: To compare young adult patients (20–40 y.o.) with isolated systolic...
75. P45 Comparison of Systemic and Regional Vascular Parameters Using New Ultrasound Techniques: Are they Clinically Useful?
Pedro Forcada, Miguel Sangiovanni, Wanda Pampinella, Oscar Montaña
Pages: S85 - S85
Background: US is a simple, reproducible and economic technique for vascular evaluation. New technologies using radiofrequency and multidimensional Doppler plus computer development allow to evaluate parameters like shear stress, Flow profile and vascular remodeling no invasively. Objective: To compare...
Samuel Vennin, Ye Li, Jorge Mariscal-Harana, Haotian Gu, Henry Fok, Jordi Alastruey, Phil Chowienczyk
Pages: S86 - S86
The influence of arterial and ventricular parameters on the main fiducial pressure points and index during systole has been investigated using a mix of in silico and in vivo data. Notably, an index, QIx, based entirely on ventricular ejection patterns has been developed and its potential in describing...
Claudia Yanette Galan Ruiz, David Cardona Müller, Ernesto Germán Cardona Muñoz, Sylvia Elena Totsuka Sutto, Brandon Giovany Illescas Vidrio, Fernando Grover Páez, Carlos Gerardo Ramos Becerra
Pages: S87 - S87
Hypertension (HTN) is considered within the first 9 preventable causes of death in Mexico . In order to estimate HTN prevalence in students a blood pressure (BP) measuring campaign was performed at the University of Guadalajara. Methods: BP was measured in morning shift students, none with known...
78. P48 Effects of Remote Ischaemic Preconditioning on Haemodynamic and Arterial Stiffness Parameters in Patients Undergoing Lower Limb Angiographic Procedure
Karl Kuusik, Teele Kepler, Mihkel Zilmer, Jaan Eha, Mare Vähi, Kaido Paapstel, Jaak Kals
Pages: S88 - S88
Objectives: Remote ischaemic preconditioning (RIPC) is a phenomenon that promotes protection of tissues and organs against ischaemia-reperfusion injury. RIPC has been shown to reduce myocardial and renal injury but its effect on arterial stiffness in patients undergoing lower limb digital subtraction...
Lennart van de Velde, Michel Reijnen, Michel Versluis, Joerg Tessarek, Erik Groot Jebbink
Pages: S89 - S90
Purpose: Flow diverting stents are commonly used in saccular cerebral aneurysms . Their use has not yet been investigated for popliteal aneurysms, which are commonly fusiform in nature and exposed to pulsatile triphasic flows. We have shown the clinical feasibility of flow diverters in a pilot study...
80. P50 The Administration of Losartan/Amlodipine in Fixed Combination Versus Losartan Improves the Hemodynamic and Arterial Stiffness Parameters in Patients with Systemic Hypertension Grade 1 and 2
Mayra Jimenez, Fernando Grover, Marycruz Barocio, Ernesto Cardona, Patricia Quezada, Jhonatan Trujillo, David Cardona, Carlos Ramos
Pages: S91 - S91
Purpose/Background/Objectives: Hypertension (HAS) represents 9.4 million deaths from all the cases of cardiovascular disease worldwide . The pulse wave velocity (PWV) and some hemodynamic parameters have been associated with this outcome [2,3]. Losartan, as well as amlodipine, have shown benefits...
81. P51 Effects of Pulsatile Exercise-induced Shear Stress on eNOS, SOD, VCAM-1, and ICAM-1 mRNA Expression of Human Carotid Artery Endothelial Cells
Francisco Morales-Acuna, Alvaro Gurovich
Pages: S92 - S92
Exercise-induced endothelial shear stress (ESS) has been proposed as a molecular mechanism that regulates the expression of genes involved in the protection against atherosclerosis. However, research on this topic has not considered the pulsatile nature of blood flow for in vivo ESS estimations. Purpose:...
Vasiliki Gardikioti, Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Konstantinos Toutouzas, Evangelia Christoforatou, Maria Xanthopoulou, Georgios Benetos, Georgios Latsios, Gerasimos Siasos, Evangelia Mpei, Manolis Vavuranakis, Dimitrios Tousoulis
Pages: S93 - S93
Purpose/Background/Objectives: Aortic stiffness and hemodynamics are independent predictors of adverse cardiovascular events. Transcatheter aortic valve implantation (TAVI) is growingly used in high surgical risk patients with aortic valve stenosis. We sought to investigate the effect of TAVI on aortic...
83. P53 More than 2-Year Follow-up of Resistant Hypertensive Patients with Neurovascular Decompression of the Brain Stem on the Left Side
Imola Fejes, Erika Vörös, Pál Barzó, Dóra Bajcsi, Annamária Letoha, Sándor Sonkodi, György Ábrahám, Péter Légrády
Pages: S94 - S94
In the background of resistant hypertension (RHT) the neurovascular pulsatile compression (NVPC) of the left rostral ventrolateral medulla may play a role. In these cases, a neurosurgical decompression (NVD) decreased the blood pressure (BP) and the antihypertensive medication became more effective....
84. P54 Age-specific, Pressure-independent Acute Changes in Carotid-femoral Pulse Wave Velocity During Head-up Tilt
Giacomo Pucci, Alberto Avolio, Bart Spronck, Gaetano Vaudo, Fabio Anastasio, Anton H. Van den Meiracker A.H, Francesco U.S. Mattace-Raso
Pages: S95 - S95
Introduction: Acute, gravity-induced blood pressure (BP) changes during head-up tilt may generate concomitant variations in carotid-femoral pulse wave velocity (cf-PWV). We aimed to separate the pressure-dependent and -independent components of cf-PWV changes observed during head-up tilt. Methods: 30...
Teele Kepler, Karl Kuusik, Urmas Lepner, Joel Starkopf, Mihkel Zilmer, Jaan Eha, Kaido Paapstel, Jaak Kals
Pages: S96 - S96
Objectives: The primary aim of this study was to evaluate the effects of remote ischaemic preconditioning (RIPC) on preventing the leakage of cardiac damage biomarkers in patients undergoing vascular surgery. Methods: Randomised, sham-controlled, double-blinded, single-centre study has been carried...
Péter Légrády, Bernadett Nádasdi, Annamária Letoha, Alexandra Gyói, Dóra Bajcsi, Kypros Constantinou, Imola Fejes, Endre Nagy, Tibor Szakál, Erika Vörös, Sándor Sonkodi, György Ábrahám
Pages: S97 - S97
There is no consensus on the antihypertensive effect and on the ability to preserve kidney function of ballon dilatations and/or stent implantation these in renal artery stenosis. From 2007 to 2016 at the 1st Department of Medicine, Nephrology-Hypertension Center, University of Szeged, total of 80 patients...
87. P57 In Patients with Chronic Descending Aorta Dissection the Maximum Systolic Flow Deceleration Rate in the False Lumen is Associated with Aortic Dilatation: a 4D-flow MRI Study
Andrea Guala, Aroa Ruiz-Muñoz, Lydia Duz-Santoy, Gisela Teixido-Tura, Chiara Granato, Augusto Sao-Aviles, Lucia La Mura, Angela Lopez-Sainz, Maria Luz Servato, Arturo Evangelista, Ignacio Ferreira, Jose Rodriguez-Palomares
Pages: S98 - S98
Background: Aortic type B dissection is a life-threating condition in which blood flows between aortic wall layers. Despite a role for morphological variables, such as entry tear location and dimension, in the prediction of progressive false lumen (FL) dilation has been suggested, the role of flow characteristics...
88. P58 Structured Exercise Training is Associated with Better Post Occlusive Reactive Hyperaemia in Skeletal Muscle Measured using Near Infrared Spectroscopy (NIRS)
Chirag Rao, Siana Jones, Khadija Ezzi, Alun Hughes
Pages: S99 - S99
Background: Participation in structured exercise training may improve microvascular function. Post occlusive reactive hyperaemia (PORH) is a measure of microvascular function in skeletal muscle and can be assessed using near-infrared spectroscopy (NIRS). We examined PORH following a short and a long...
89. P59 Marked Differences in Cerebral Haemodynamics Obtained with Transcranial Doppler vs. 2-D Angle-corrected Ultrasound
Christopher Brown, Mahfoudha Al Shezawi, Laura Watkeys, Maggie Munnery, Christopher Pugh, Eric Stöhr, Barry McDonnell
Pages: S100 - S100
Introduction: The assessment of middle cerebral artery (MCA) haemodynamics is essential for the diagnosis and monitoring of cerebrovascular disease. However, conventional transcranial Doppler (TCD) may not capture the correct flow velocities because of sub-optimal angles of insonation. Conversely, 2-D...
90. P60 Invasive Validation of Antares, a New Algorithm to Calculate Central Blood Pressure from Oscillometric Upper Arm Pulse Waves
Marcus Doerr, Stefan Richter, Siegfried Eckert, Marc-Alexander Ohlow, Fabian Hammer, Astrid Hummel, Vivien Dornberger, Elisabeth Genzel, Johannes Baulmann
Pages: S101 - S101
Background: Antares is an algorithm for pulse wave analysis (PWA) by oscillometric blood pressure monitors in order to estimate central (aortic) blood pressure (cBP). Antares aims to enable brachial cuff-based blood pressure (BP) monitors to be type II-devices, determining absolute cBP values independently...
Béla Benczúr, Renata Bocskei, Attila Cziraki
Pages: S102 - S102
It has been proven that aortic pulse wave velocity (aoPWV), the measure of arterial stiffness is a strong and independent predictor of both cardiovascular events and all-cause mortality. Beyond the “gold standard” cfPWV (carotid-femoral) a plenty of methods are available for measuring PWV but the interpretation...
Alun Hughes, Kim Parker, Nish Chaturvedi, Chloe Park
Pages: S103 - S104
Background: Measurement of wave intensity (WI) requires simultaneous or quasi-simultaneous measurement of pressure and flow limiting its use. Previous work in dogs  and humans  has shown that the excess pressure waveforms calculated using reservoir analysis correspond closely with aortic flow waveforms....
93. P63 Accuracy (Validation) of Central Blood Pressure Measurement Using the Sphygmocor Xcel-cuff Device
Martin Schultz, Dean Picone, Matthew Armstrong, Andrew Black, Nathan Dwyer, Philip Roberts-Thomson, James Sharman
Pages: S105 - S105
Background: Numerous devices purport to measure central aortic BP as distinct from conventional brachial BP. This study aimed to determine the accuracy (validation) of the Sphygmocor Xcel-cuff device (AtCor Medical, Sydney, Australia) for measuring central BP. Methods: 330 patients (mean age 61.3 ±...
94. P64 Carotid Artery Tracking with Automated Wall Position Resets Yields Robust Distension Waveforms in Long-term Ultrasonic Recordings
Fabian Beutel, Laura Mansilla Valle, Chris Van Hoof, Evelien Hermeling
Pages: S106 - S107
Background: Carotid artery tracking has high clinical relevance for the investigation of arterial stiffness indicators like Pulse Wave Velocity (PWV). However, current tracking systems are unreliable and/or not fully automated [1,2]. In this work we propose a novel wall tracking algorithm for long-term...
95. P65 A Beat-to-Beat Quality Indicator Based on Piecewise Spatiotemporal Estimates of Carotid Pulse Wave Velocity Improves Correlation with Pulse Pressure
Fabian Beutel, Chris Van Hoof, Evelien Hermeling
Pages: S108 - S109
Background: Local carotid pulse wave velocity (PWV) estimation is challenging due to a complex anatomy and associated wave reflections . Wave interference is both blood pressure (BP) and position dependent, hence causing nonlinearity in the spatiotemporal PWV estimation . In lack of beat-to-beat...
Nikolaos Fountoulakis, Karla Sanchez-Cazares, Kim Parker, Janaka Karalliedde
Pages: S110 - S110
Background: Diabetes is one of the leading causes of chronic kidney disease (CKD) worldwide. CKD is directly linked to increased morbidity and mortality. The role of vascular changes in diabetes and underlying mechanism of kidney disease is not well understood. Methods: We present a mathematical model...
Björn van der Ster, Marije Wijnberge, Marthe Huntelaar, Job de Haan, Koen van der Sluijs, Denise Veelo, Berend Westerhof
Pages: S111 - S111
Background: Hemodynamic optimization of unstable patients by means of fluid resuscitation improves patient outcome, but choosing the correct amount of fluid can be difficult. Too little fluid may not ensure adequate perfusion whereas too much fluid is associated with increased mortality. Static parameters...
98. P68 Usefulness of an Optimal Cut-off in Central Augmentation Pressure for the Detection of Left Ventricular Hypertrophy in Men
Masakazu Obayashi, Shigeki Kobayashi, Hirotaka Yamamoto, Yoriomi Hamada, Takumi Nanno, Michihiro Kohno, Masafumi Yano
Pages: S112 - S112
Background: Recently, we showed an age-related increase in augmentation pressure (AP) measured using Mobil-O-Graph (MOG) in normotensive Japanese individuals. However, AP might be a poor index of wave reflection due to the overlap between the forward wave and reflected wave. Methods: We enrolled untreated...
99. P69 The Initial Upstroke Time is Most Strongly Associated with the Severity of as Among Brachial Pulse Wave Parameters
Masao Takahashi, Kyohei Fukatani, Tomoyuki Kabutoya, Satoshi Hoshide, Tatsuya Yoneyama, Tetsuya Ito, Kazuomi Kario
Pages: S113 - S113
Background: Aortic valve stenosis (AS) is the most common valve disease in an elderly population, therefore, simple screening examination for AS is needed. Although a prolonged carotid upstroke time (UT), and prolonged ejection time (ET) of a brachial pulse wave (BPW) have been observed in severe AS...
100. P70 Effects of Different Vitamin D Status on Mechanical, Pharmacological and Histological Characteristics of Coronary Arterioles in Male Rat Model
Reka Eszter Sziva, Zoltan Fontanyi, Eva Pal, Leila Hadjadj, Anna Monori-Kiss, Eszter Maria Horvath, Rita Benko, Attila Magyar, Andrea Heinzlmann, Zoltan Benyo, Gyorgy L. Nadasy, Szabolcs Varbiro, Bálint Bányai
Pages: S114 - S114
Objectives: The cardiovascular/CV risk is higher in males. To know better these increased risks, our aim was to investigate the effects of different vitamin D/VD status on mechanical, pharmacological and histological characteristics of coronary arterioles in male rat model. Methods: In male Wistar-rats...
101. P71 The Interrelationship Between the Alteration of Arterial Markers and Left Ventricular Diastolic Dysfunction in Metabolic Syndrome Subjects
Svetlana Solovjova, Ligita Ryliskyte, Jelena Celutkiene, Jolita Badariene, Aleksandras Laucevicius
Pages: S115 - S115
We aimed to determine how the alteration of arterial stiffness (AS) affects the dynamics of left ventricular (LV) diastolic dysfunction (DD) in metabolic syndrome (MetS) subjects during longitudinal observation (3.8 ± 0.6 years). Methods: A follow-up study was carried out in 573 (53.4 ± 5.8 years, 211...
Agne Laucyte-Cibulskiene, Ligita Ryliskyte, Milda Kovaite, Laurynas Rimsevicius, Laura Balkeviciene, Jolita Badariene, Aleksandras Laucevicius
Pages: S116 - S116
Aim: To assess a time-dependent change of arterial stiffness gradient (PWVratio calculated by dividing carotid-femoral to carotid-radialPWV), a marker of vascular aging, in high cardiovascular risk cohort. Methods: This cohort study (n = 689) was conducted during the period 2010–2019 at Vilnius University...
Eszter Szabó, Krisztina Gáspár, Ildikó Szabó, Viktória Kovács, Zsuzsanna Pál, Gábor Simonyi, Endre Kolossváry, Katalin Farkas
Pages: S117 - S117
Background: Arterial stiffness is the characteristic of early vascular damage that can be measured by several methods. Sphygmocor determines the carotid-femoral pulse wave velocity (PWV). Cardio-ankle vascular index (CAVI) also measures PWV between heart and ankle, independently of blood pressure. According...
Adrienn Bárczi, Arianna Dégi, Orsolya Cseprekál, Eva Kis, Ádám Szabó, Gábor Rudas, George S Reusz
Pages: S118 - S118
Background: Aortic pulse wave velocity (PWV) is the gold standard measurement for arterial stiffness. Normative values exist for PWV in children using the subtracted method (LSM) for the estimation of the distance, however no imaging validation studies in the growing pediatric population. The formula...
105. P76 Carotid Artery Disease in Patients with Newly Diagnosed, Untreated Familial Hypercholesterolemia
Bíborka Nádró, Beáta Kovács, Ágnes Diószegi, Lilla Juhász, Dénes Páll, György Paragh, Mariann Harangi
Pages: S119 - S119
Familial hypercholesterolemia (FH) patients are characterized by markedly elevated LDL-cholesterol (LDL-C) concentration, positive family history of hypercholesterolemia and premature vascular complications including carotid artery disease (CAAD). Carotid plaques are associated with atherosclerosis of...
106. P77 Long-term Effects of LDL Apheresis on Carotid Arterial Atherosclerosis in Two Severe Heterozygous Familial Hypercholesterolemic Patients
Ágnes Diószegi, Lilla Juhász, Bíborka Nádró, György Paragh, László Oláh, Dénes Páll, József Balla, Mariann Harangi
Pages: S120 - S120
The long-term effects of low-density lipoprotein (LDL) apheresis (LA) on the progression and regression of atherosclerosis were evaluated by carotid ultrasonography in two severe heterozygous familial hypercholesterolemic patients with carotid artery stenosis. Furthermore, the lipid-lowering efficacy...
Maimouna Toure, Magid Hallab, Souleymane Thiam, Sheikh AB Mane, Farid Belem, Abdoulaye Samb
Pages: S121 - S121
Objective: We aimed to study Endothelial dysfunction and Arterial Stiffness in Diabetes mellitus. Methods: 29 women with type 2 diabetes and 8 non-diabetic controls were included. Vascular function was studied with pOpmetre® (Axelife SAS-France) to assess the foot to toe Pulse Wave Velocity; and EndoPAT2000®...
108. P79 Non-invasive Estimation of Central Pressures in Abdominal Aortic Aneurysm Patients and Changes in PWV After EVAR
Suzanne Holewijn, Lennart van de Velde, Jenske Vermeulen, Michel Reijnen
Pages: S122 - S122
Background: Abdominal aortic aneurysm (AAA) disease is mainly treated by endovascular aneurysm repair (EVAR) and PWV has been shown to increase after EVAR. Arterial stiffness is predictive of cardiovascular disease, but has not been investigated in AAA-patients. We investigated if central pressures (CP)...
109. P80 Predictors of Middle Cerebral Artery Pulsatility Index in Chronic Obstructive Pulmonary Disease and Healthy Controls; Data from the ACRADE Study
Mahfoudha Al Shezawi, Maggie Munnery, John Cockcroft, Laura Watkeys, Eric Stohr, Nichola Gale, Barry McDonnell
Pages: S123 - S123
Background: Chronic obstructive pulmonary disease (COPD) is characterised by airway limitation which is an independent predictor of increased cardiovascular (CV) risk and mortality . COPD is associated with increased arterial stiffness  and increased incidence of all stroke subtypes . However,...
110. P81 Antibody to Cardiotonic Steroid Reduces Blood Pressure and Vascular Fibrosis in Preeclampsia
NI Agalakova, VA Reznik, OV Nadei, IA Ershov, OS Rassokha, ML Vasyutina, MM Galagudza, AY Bagrov
Pages: S124 - S124
Background: Previous studies implicated cardiotonic steroids, including Na/K-ATPase inhibitor marinobufagenin (MBG), in the pathogenesis of preeclampsia (PE). We demonstrated that MBG induces fibrosis via mechanism involving inhibition of Fli1, a nuclear transcription factor and a negative regulator...
Nikolaos Koletsos, Eugenia Gkaliagkousi, Antonios Lazaridis, Panagiota Anyfanti, Areti Triantafyllou, Konstantina Dipla, Panagiotis Dolgyras, Vasiliki Galanopoulou, Spyros Aslanidis, Stella Douma
Pages: S125 - S125
Objectives: Alterations in skin microcirculation have been associated with damage in various microvascular beds . Endothelial dysfunction in microcirculation plays a central role in the pathophysiology of rheumatic diseases, contributing substantially to the increased cardiovascular risk of these...
Tetsu Yamakado, Hideyoshi Ko
Pages: S126 - S126
Background: Reservoir pressure analysis has been newly introduced to analyze arterial waveform and function. There are few data regarding the effect of aging on the aortic reservoir and excess pressures in normal humans. Objectives and Methods: To investigate this issue, we analyzed high-fidelity aortic...
113. P84 Prediction of Cardiovascular Events and Mortality by Pulse Wave Velocity: a Comparison of Invasive Measurements and Noninvasive Estimation Methods
Bernhard Hametner, Siegfried Wassertheurer, Christopher Clemens Mayer, Kathrin Danninger, Ronald Binder, Thomas Weber
Pages: S127 - S127
Introduction: Arterial properties are linked to the presence and severity of coronary artery disease (CAD). Coronary blood flow is strongly and inversely related to arterial stiffness. Thus, the aim of this prospective study was to evaluate the prognostic value of PWV in high-risk patients with suspected...
114. P85 Acute Systemic Inflammation Reduces both Carotid and Aortic Wave Reflection in Young Healthy Adults
Elizabeth Schroeder, Wesley Lefferts, Thessa Hilgenkamp, Bo Fernhall
Pages: S128 - S128
Acute inflammation increases the risk of cardiac and cerebrovascular events, potentially associated with altered hemodynamic load. Wave reflection at the aorta and carotid artery can contribute to central hemodynamic load and provide insight into downstream changes in vascular tone. Acute inflammation...
115. P86 Can Central Blood Pressure be Accurately Estimated in Individuals with and Without Systolic Blood Pressure Amplification?
Goupil Remi, Cédric Kowalski, Florence Lamarche
Pages: S129 - S129
Introduction: Systolic blood pressure (SBP) does not always amplify from central to peripheral arteries. Individuals without SBP amplification (SBPamp) have higher aortic blood pressure (BP) despite similar brachial cuff SBP. To circumvent this discrepancy, the aim of this study was to determine if aortic...
116. P87 Ultra–high Frequency Ultrasound Assessment in Vascular Ehlers Danlos Syndrome: a Validation and Reproducibility Study
Rosa Maria Bruno, Magdalini Alexopoulou, Hakim Khettab, Xavier Jeunemaitre, Pierre Boutouyrie
Pages: S130 - S130
Background: In patients with Vascular Ehlers-Danlos syndrome (vEDS), an abnormally low carotid intima-media thickness (CIMT) may increase the risk of arterial dissection and rupture. Thus its accurate assessment by ultra–high frequency ultrasound (UHFUS), thanks to its higher spatial resolution, may...
117. P88 Improvement in Functional Capacity with Spironolactone Masks the Treatment Effect on Exercise Blood Pressure
Myles Moore, Martin Schultz, James Hare, Thomas Marwick, James Sharman
Pages: S131 - S131
Background: A hypertensive response to submaximal exercise is associated with cardiovascular disease but may be influenced by functional capacity. Spironolactone may improve functional capacity, which could mask treatment effects on exercise blood pressure (BP). This study sought to examine this hypothesis. Methods:...
Pages: S132 - S132
Blood pressure is most important parameter reflecting hemodynamic factors, however it is continuously variable in 24 hours. Here, we made a non-invasive and continuous BP measurement device using a three-axis tactile force sensor. All the data was collected every 2 min for the short-term experiment,...
119. P90 Indexing Left Ventricular Mass to Body Size: Which Method is the Most Appropriate in Early Adulthood?
Hannah Taylor, Chloe Park, Abigail Fraser, Laura Howe, Dianna Ferreira, Nic Timpson, Debbie Lawlor, George Davey-Smith, Nishi Chaturvedi, Alun Hughes
Pages: S133 - S133
Introduction: Left ventricular mass (LVM) predicts cardiovascular risk. In early life, LVM is conventionally indexed to height 2.7 , although this may not account for sex differences in growth. We investigated allometric scaling of LVM to height, lean mass (LM) and body surface area (BSA) in a UK...
120. P92 The Association of Agreeableness and Conscientiousness with 24-Hour Brachial Blood Pressure and Hemodynamic Parameters in Untreated Hypertensive Patients
Milán Vecsey-Nagy, Beáta Kőrösi, Dóra Batta, Xénia Gonda, Zoltán Rihmer, Zsófia Nemcsik-Bencze, Andrea László, János Nemcsik
Pages: S134 - S134
Background: There is growing evidence that Five Factor Model personality traits (extraversion agreeableness, conscientiousness, neuroticism, and openness) have an impact on cardiovascular (CV) risk. The aim of our study was to evaluate their associations with 24-hour brachial and central hemodynamic...
121. P93 Relationship Between Central Pressure and Urinary Sodium Excretion in a Population-based Study in Salvador, Brazil, Preliminary Results
Roberta de Castro, Lucélia Magalhães, Danielle Brustolim, Diorlene da Silva, Antonio Filho, Larissa Bessa, Grupo Vascor
Pages: S135 - S135
Introduction: Central pressure (CP) has shown to be more reliable than cardiovascular mortality; salt intake in the diet is directly related to the increase in CP. Methods: A population-based cross-sectional study representative of a neighborhood of Salvador-BA, Brazil, distributed in 12 census tracts...
122. P94 Relationship Between Central Pressure and Potassium Urinary Excretion in a Population-Based Study in Salvador, Brazil, Preliminary Results
Antonio Filho, Lucélia Magalhães, Danielle Brustolim, Diorlene da Silva, Roberta de Castro, Larissa Bessa, VASCOR grupo VASCOR
Pages: S136 - S136
Introduction: Central pressure (CP) has been shown to be more reliable in cardiovascular mortality than peripheral. Previous studies correlate the relationship between CP increase and urinary potassium excretion. Methods: A population-based cross-sectional study representative of a neighborhood of Salvador-Ba,...
123. P96 Soluble Receptor for Advanced Glycation End-products Independently Influenced Individual Age-dependent Increase of Arterial Stiffness
Pages: S137 - S137
Background: Soluble receptors for advanced glycation end-products (sRAGEs) have been suggested to have a protective role neutralizing the advanced glycation end-products (AGEs) and their pathological effect on vessel walls. We aimed to investigate the association between circulating concentrations of...
124. P97 Age Modifies the Relationship Between Arterial Stiffness, Adiposity and Blood Pressure from Adolescence to Adulthood in Men and Women
Chloe Park, Marietta Charakida, Laura Howe, Abigail Fraser, Alicja Rapala, Suzanne Williams, Siana Jones, John Deanfield, Nish Chaturvedi, Alun Hughes
Pages: S138 - S138
Introduction: Adult obesity is associated with greater arterial stiffness however in youth the relationship is unclear. We investigated associations between arterial stiffness and adiposity and explored the contribution of blood pressure from adolescence to emerging adulthood (17–24 yrs). Methods: 3885...
125. P98 Impaired Pulmonary Function is Associated with Increased Cardio-ankle Vascular Index in Hiv Patients in Ghana
Kwame Yeboah, Latif Musah, Samuel Essel, Bartholomew Dzudzor, J Kennedy Cruickshank
Pages: S139 - S139
Aim: Patients with HIV have increased cardiovascular risk and pulmonary defects. We investigated the association between impaired pulmonary function (IPF) and arterial stiffening measured by the cardio-ankle vascular index (CAVI) in Ghanaian HIV patients. Method: Spirometry was used to measure pulmonary...
Valentina Vassilenko, Andreia Serrano, Beatriz Ramalho, Paulo Bonifácio, Ana C. Coelho, Fernando Pimentel-Santos
Pages: S140 - S140
Aging often results in the appearance of sarcopenia, which is characterized by loss of muscle mass and strength. The incidence of sarcopenia in the elderly is a quite common and leads to weakness and disability, as well as a lower quality of life, also assuming a high social and economic impact. One...
127. P102 Large Artery Stiffness is Associated with Lower Brain pH and Memory Performance in Middle-aged and Older Adults
Lyndsey DuBose, Vincent Magnotta, David Moser, Gary Mitchell, Virginia Nuckols, Ryan Ward, Gary Pierce, Laura Boles Ponto
Pages: S141 - S141
Background/Objectives: Large artery stiffening is a novel risk factor for cognitive impairment including Alzheimer’s disease. Loss of impedance mismatch between central and cerebral arteries promotes cerebrovascular dysfunction via chronic transmission of excessive pulsatile pressure and flow to the...
128. P103 Improved Metabolic Vasoreactivity in the Brain of HM3 Patients and its Underlying Microcirculatory Mechanisms
Eric J. Stöhr, Ruiping Ji, Koichi Akiyama, Francesco Castagna, Pinsino Alberto, John Cockcroft, Melana Yuzefpolskaya, Reshad Garan, Veli Topkara, Hiroo Takayama, Koji Takeda, Yoshifumi Naka, Paolo Colombo, Joshua Willey, Barry J. McDonnell
Pages: S142 - S143
Background: The MOMENTUM3 trial1 has revealed superiority of the novel HeartMate3 (HM3) left ventricular assist device (LVAD) compared with the HM2, with a significantly reduced occurrence of cerebrovascular accidents. Thus, cerebral autoregulation may be improved in HM3 compared with HM II patients,...
Fran Kirkham, E Drazich, A Vundavalli, P Rankin, J Timeyin, E Bunting, K Ali, C Rajkumar
Pages: S144 - S144
Objective: Small vessel disease, measured by brain white matter hyperintensity (WMH), is associated with increased stroke risk and cognitive impairment. This study aimed to explore the relationship between WMH on computerised tomography (CT) and white coat hypertension (WCH) in patients with recent transient...
130. P105 Photoplethysmographic Signals Analysis Before, During, and After the Finnish Sauna Exposures
Pages: S145 - S145
Wellness and healthiness depend on physiology if no illness exists in the body. As a treatment either in healthy or sick state, we suggest that sauna exposure could be good for cardiovascular disease (CVD) prevention, especially heart and brains arteries. We measured by our photoplethysmographic (PPG)...
Tainah Ortiz, Fernanda Gorski, Tatiana Lehnen, Liliana Boll, Bruna Eibel, Alexandre Lehnen, Eduardo Barbosa
Pages: S146 - S146
Introduction: Açaí-juçara is a fruit with a antioxidant content that can modify the vascular environment and attenuate the effects of obesity. Objective: To evaluate the effect of açaí-juçara on pulse pressure parameters in overweight or obese individuals. Methods: Randomized clinical trial with 23...
132. P107 Endothelial Dysfunction Associated with Arterial Stiffness in Postmenopausal Women with Obesity
Patricia Lizette Ramírez Soltero, Leonel García Benavides, Marycruz Barocio Pantoja, Brandon Giovanni Illescas Vidrio, David Cardona Müller, Ernesto Germán Cardona Muñoz, Sylvia Elena Totsuka Sutto
Pages: S147 - S147
Background: Endothelial dysfunction (ED) represents an initial step of “vascular failure” ; several factors affect the functionality of the endothelium. Obesity  and estrogen deficiency  are independently associated with this. The early detection of ED is essential to intervene and prevent its...
133. P108 Relation Between Abdominal Aorta and Carotid Artery Responses to Sympathetic Stimulation using Duplex Ultrasound
Anne-Jet Jansen, Jenske Vermeulen, Suzanne Holewijn, Dick Thijssen, Michel Reijnen
Pages: S148 - S148
Background: Sympathetic stimulation in central arteries, such as the carotid artery, lead to vasodilation in healthy subjects and vasoconstriction in those with cardiovascular disease. Moreover, this response has independent prognostic value for future events. Whether the aorta demonstrates similar responsiveness...
Elif Stoneman, Dean Picone, Martin Schultz, Matthew Armstrong, Willem Bos, Nathan Dwyer, Peter Lacy, Esben Laugesen, Stefano Omboni, Giacomo Pucci, Philip Roberts-Thomson, George Stouffer, Kenji Takazawa, Thomas Weber, Berend Westerhof, James Sharman
Pages: S149 - S149
Background: Cuff blood pressure (BP) is intended to approximate central aortic BP and accuracy is paramount. Sex differences in BP physiology could influence the accuracy of cuff BP as an estimate of invasive aortic BP, but this has not been explored in-depth and was the aim of this study. Methods:...
Luca Faconti, Ryan McNally, Bushra Farukh, Phil Chowienczyk
Pages: S150 - S150
Background: Effects of afterload and blood pressure (BP) on pulse wave velocity (PWV) have been investigated using vasoactive drugs but effects of cardiac pre-load have not previously been studied. Methods: Transient mechanical reduction of cardiac pre-load (lower limb venous occlusion, LVO) and expansion...
Anna Paini, Carlo Aggiusti, Fabio Bertacchini, Deborah Stassaldi, Sara Capellini, Enrico Agabiti Rosei, Maria Lorenza Muiesan, Massimo Salvetti
Pages: S151 - S151
Measurement of “unattended” blood pressure (BP) may reduce or eliminate the “white coat effect”. Despite the possible advantages of this approach for BP measurement, only few studies analysed the relationship between unattended BP and cardiovascular events or with hypertension mediated organ damage (HMOD)....
137. P112 Influence of Cuff Blood Pressure Accuracy on Identification of Isolated Systolic Hypertension
Dean Picone, Martin Schultz, Matthew Armstrong, Willem Bos, Nathan Dwyer, Peter Lacy, Esben Laugesen, Stefano Omboni, Giacomo Pucci, Philip Roberts-Thomson, George Stouffer, Kenji Takazawa, Thomas Weber, Berend Westerhof, James Sharman
Pages: S152 - S152
Introduction: Isolated systolic hypertension (ISH) is the most common form of hypertension in older people. However, accurate identification of ISH may be hindered because cuff blood pressure (BP) underestimates systolic BP (SBP) and overestimates diastolic BP (DBP). This study aimed to determine the...
138. P113 The Forgotten Black Box of Blood Pressure: Error in Oscillometric Mean Arterial Pressure is Associated with Cuff Measurement Inaccuracy
Dean Picone, Martin Schultz, Matthew Armstrong, Nathan Dwyer, Philip Roberts-Thomson, Thomas Weber, James Sharman
Pages: S153 - S153
Background: Accurate measurement of cuff systolic BP (SBP) and diastolic BP (DBP) is contingent on the assumption of oscillometric MAP being accurate. If MAP is inaccurate this is likely to impact the accuracy of cuff SBP and DBP, but this has never been determined and was the aim of the study. Methods:...
139. P114 “Stifflammation” is an Essential Cause of Cardiovascular Hospitalizations in Hypertensives
Georgia Christopoulou, Charalambos Vlachopoulos, Lambros Korogiannis, Dimitrios Terentes-Printzios, Evangelia Sigala, Iosif Koutagiar, Vasiliki Gardikioti, Dimitrios Tousoulis
Pages: S154 - S154
Purpose/Background/Objectives: Hypertension is associated with increased cardiovascular risk, inflammation and arterial stiffness. We sought to investigate the role of inflammation and arterial stiffness in the prognosis of cardiovascular hospitalization in hypertensives patients over an extensive follow-up. Methods:...
140. P115 Does Post-stroke White Coat Hypertension/Effect (WCH/E) Require Intensive Blood Pressure Management?
Fran Kirkham, GN Nuredini, A Saunders, Erin Drazich, Eva Bunting, Philip Rankin, K Ali, M Okorie, Chakravarthi Rajkumar
Pages: S155 - S155
Objective: International guidelines advocate conservative management of post-stroke white coat hypertension. The aims of this study were to investigate; i) does WCH/E result in increased stroke risk? and ii) is WCH/E associated with surrogate markers of cardiovascular risk? Methods: The Arterial Stiffness...
Fran Kirkham, A Saunders, GN Nuredini, E Drazich, Philip Rankin, E Bunting, K Ali, M Okorie, C Rajkumar
Pages: S156 - S156
Objective: White coat hypertension/effect (WCH/E) describes an elevated clinic blood pressure (BP) with normal daytime ambulatory BP (ABPM) values. It is not clear whether WCH/E is associated with adverse vascular risk. This study aimed to determine the relationship between WCH/E and arterial stiffness...
142. P117 Case Report of a Patient with Extreme Reverse Dipping Phenomenon Decades After Kidney Transplantation
Dóra Batta, Beáta Kőrösi, Zsófia Nemcsik-Bencze, János Nemcsik
Pages: S157 - S157
A patient with the complaint of moderately elevated blood pressure came to our office. Important data in his history was kidney transplantation in 1985, due to glomerulonephritis and since that time he was in regular nephrology care. He also had chronic lumboischialgia, chronic hypertension and stage...
143. P118 Arterial Stiffness in Patients with Arterial Hypertension on Short Term Dual Treatment with Fimasartan/Amlodipine
Brandon Giovany Illescas Vidrio, David Cardona Müller, Ernesto Germán Cardona Muñoz, Claudia Yanette Gálan Ruiz, Carlos Gerardo Ramos Becerra, Fernando Grover Páez
Pages: S158 - S158
Background: Pulse wave velocity (PWV) reflects arterial stiffness and is an independent predictor of cardiovascular mortality and morbidity. It is important to determine the effect dual therapy has on both BP and PWV. Methods: A quasi-experimental study was performed in patients with grade 1 and 2 primary...
144. P119 Carotid Stiffness is Strongly Associated with Skin Microvascular Dysfunction in Normotensives and Newly-diagnosed Hypertensives
Antonios Lazaridis, Eugenia Gkaliagkousi, Nikolaos Koletsos, Eleni Gavriilaki, Panagiota Anyfanti, Barbara Nikolaidou, Areti Triantafyllou, Konstantina Dipla, Stella Douma
Pages: S159 - S159
Background/Objectives: Skin microcirculation represents an easily accessible window reflecting generalized microvascular dysfunction. It has been correlated with alterations in several microvascular beds, though evidence regarding its association with macrovascular damage is scarce. Carotid artery stiffening...
Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Georgia Christopoulou, Lampros Korogiannis, Panos Xydis, Vasiliki Gardikioti, Eirini Solomou, Nikolaos Ioakeimidis, Christos Georgakopoulos, Ioanna Dima, Dimitrios Tousoulis
Pages: S160 - S160
Purpose/Background/Objectives: Cardiac autonomic dysfunction is associated with increased cardiovascular mortality and arrhythmias. The aim of the study was to investigate the effect of heart rate variability (HRV) in the prognosis of future arrhythmic events. Methods: We studied 292 untreated at baseline...
David Laszlo Tarnoki, Helga Szabo, Kata Gyulay, Zsofia Jokkel, Rebeka Debreceni, Greta Janositz, Anita Hernyes, Viktor Berczi, Adam Domonkos Tarnoki
Pages: S161 - S161
Introduction: Development of carotid and femoral atherosclerotic plaques proved to be heritable in previous studies. However, no comprehensive ultrasonographic evaluation of the volume and types of plaque has been performed. Methods: Comprehensive carotid and femoral arterial ultrasound examination...
Koen Reesink, Louise Marais, Pierre Boutouyrie
Pages: S162 - S162
Background: Calibration of carotid artery tonometry waveforms needs to account for pulse pressure augmentation . Due to its location nearer to the heart, carotid pulse pressure (carPP) is about 10 mmHg lower than brachial (brachPP) . In practice, perfect applanation is hard to achieve with tonometry...
148. P123 Beyond Diameters, Flow Hemodynamics Quantified by Magnetic Resonance Imaging to Help Characterizing Aneurysmal Aorta
Sophia Houriez—Gombaud-Saintonge, Ariel Pascaner, Gilles Soulat, Umit Gencer, Thomas Dietenbeck, Damian Craiem, Emilie Bollache, Yasmina Chenoune, Elie Mousseaux, Nadjia Kachenoura
Pages: S163 - S163
Purpose: Referral to surgery in thoracic aortic aneurysms (TAA) is based on maximal diameter (Dmax) measured from imaging, which is known to have a high diagnosis failure rate. In addition to geometry, 4D flow MRI provides a comprehensive time-resolved flow imaging. Thus, our aim was to evaluate the...
Shima Abdullateef, Jorge Mariscal-Harana, Jordi Alastruey, Ashraf Khir
Pages: S164 - S164
Aortic tapering is a known characteristic of the arterial tree affecting the development of pressure in the aorta. With tapering, the cross-sectional area of vessels decreases moving towards the periphery causing reflections to travel back to the heart. The reflection waves present in the aorta are an...
Daimé Campos Arias, Nikos Stergiopulos, Tania Rodríguez Moliner, Patrick Segers
Pages: S165 - S166
Background: Several so-called loop-based methods, have been proposed to estimate local pulse wave velocity (PWV). However, previous studies have demonstrated inaccuracies in local PWV-estimates due to presence of reflections, which led to the proposition of a frequency-domain correction method . The...
151. P126 Characterization of Skin Temperature Changes in Response to Photobiostimulation Using Thermal Imaging: A Thermo-Anatomical Correlation
Oshrit Hoffer, Neta Rabin, Lilach Gavish, Moshe Halak, Ortal Haim, Yuval Shayovitz, Simon Shkilevich, Benjamin Gavish, Yair Zimmer, Zehava Ovadia-Blechman
Pages: S167 - S167
Background and Objective: Infrared Thermal Imaging (ITI) is a noninvasive method to measure skin temperature (ST). The latter is determined by the microcirculatory blood flow and ambient temperature. Photobiostimulation has been shown to increase blood flow. The objective was to characterize the spatial...
152. P127 Graded Cuff Compression Protocol to Induce Retrograde Shear Produces Proportionate Increment in Regional Arterial Compliance in Human Peripheral Artery
Naaz Afreen, Dinu Chandran, Ashok Jaryal, Kishore Deepak, Sitikantha Roy
Pages: S168 - S168
Background: External compression using pneumatic cuff inflation is a well-established model used to induce incremental changes in proximal retrograde flow and shear . The mechanisms behind distal cuff compression leading to proximal increase in retrograde shear are not clear. We hypothesized that...
153. P128 Accuracy of Age-appropriate Transfer Functions in Modelling Central Arterial Waveform Features
Tommy Cai, Meroni Alice, Ahmad Qasem, Mark Butlin, Julian Ayer, David Celermajer, Alberto Avolio, Michael Skilton
Pages: S169 - S169
Background: Central aortic pressure waveforms can be modelled non-invasively in adults using general transfer functions. These techniques have been applied to, but not formally validated in paediatric populations. We recently developed and validated two age-appropriate paediatric transfer functions and...
154. P129 Arterial Stiffness in Bicuspid or Tricuspid Aortic Valve Aortopathy Using Magnetic Resonance Imaging: Crossing the Physical and Hemodynamic limits?
Ariel Pascaner, Sophia Houriez—Gombaud-Saintonge, Gilles Soulat, Umit Gencer, Thomas Dietenbeck, Yasmina Chenoune, Nadjia Kachenoura, Elie Mousseaux, Damian Craiem, Emilie Bollache
Pages: S170 - S170
Purpose: To provide a comprehensive assessment of aortic stiffness, through both local and regional distensibility and pulse wave velocity (PWV), in patients with either a tricuspid (TAV) or bicuspid (BAV) aortic valve and/or aortic dilation using MRI. Methods: We included 18 patients with TAV and dilated...
155. P130 Cardiac Resynchronization Therapy Improves Early Ventricular Contraction and Reduces Time to Onset of Relaxation
Haotian Gu, Simon Claridge, Aldo Rinaldi, Phil Chowienczyk
Pages: S171 - S171
Background: Haemodynamic effects of Cardiac Resynchronisation Therapy (CRT) may be mediated by an improvement in early systolic function, as well as by improvements in overall systolic function. We examined whether CRT improves early ventricular contraction as measured by first-phase ejection fraction...
156. P134 A New Method for Non-invasive Measurement of Arterial Wave Intensity, Speed and Reflection
Ethan Rowland, Kai Riemer, Kevin Lichtenstein, Mengxing Tang, Peter Weinberg
Pages: S172 - S172
Introduction: The ventricles accelerate and decelerate blood; the resulting disturbances propagate through the arterial system as waves. These waves contain clinically useful information: e.g. their magnitude and timing varies with cardiac performance and their speed depends on arterial stiffness. These...
157. P135 Assessment of Novel Blood Pressure Corrected Cardio-ankle Vascular Index in Response to Acute Blood Pressure Changes
Michal Mestanik, Bart Spronck, Alexander Jurko, Andrea Mestanikova, Tomas Jurko, Mark Butlin, Alberto Avolio, Lucia Bona Olexova, Zuzana Visnovcova, Nikola Sekaninova, Ingrid Tonhajzerova
Pages: S173 - S173
Background: Cardio-ankle vascular index (CAVI) has long been considered a measure of arterial stiffness independent of short-term changes in blood pressure (BP) . Recently and theoretically, CAVI was found to be partially affected by actual BP, thus, a novel BP-corrected index, CAVI0, was proposed...
158. P136 Determinants of Arterial Stiffness in Children Using Population-indexed Anthropometric and Hemodynamic Parameters
Tommy Cai, Alice Meroni, Ahmad Qasem, Mark Butlin, Julian Ayer, David Celermajer, Alberto Avolio, Michael Skilton
Pages: S174 - S174
Background: Arterial stiffness is a significant cardiovascular risk factor. Carotid-femoral pulse wave velocity (cfPWV) is the standard for measuring arterial stiffness, but indices such as central augmentation index (cAIx) and carotid artery elasticity (cE[p]) also correlate to arterial stiffness. Early-life...
Berend Westerhof, Nico Westerhof
Pages: S175 - S175
Introduction: Pressure waveshape derived parameters such as the augmentation index are related to unfavourable cardiovascular events . Wave reflections determine wave shape , however, several findings seem to contradict the current views. Current view. The arterial system can be modelled by a tube...
160. P138 Modelling and Simulation of Pressure Re-reflections at the Aortic Valve Using Difference Equations
Bernhard Hametner, Hannah Kastinger, Siegfried Wassertheurer
Pages: S176 - S176
Introduction: The concept of re-reflections of blood pressure waves at the heart has been neglected in most models and is only poorly understood so far. Therefore, the aim of this work was to develop a simple mathematical model which is capable to represent the effects of wave travel, wave reflection...
161. P139 Does Early Life Programming Influence Arterial Stiffness and Central Hemodynamics in Adulthood? Could Birth Cohort Effects be of Importance?
Peter Nilsson, Johannes Sperling
Pages: S177 - S177
Objective: Our aim was to investigate possible associations between birth weight (BW) and adult carotid-femoral Pulse Wave Velocity (cfPWV) and augmentation pressure index (AIx). Design: This study including 1598 participants, 340 elderly subjects and 1258 young-middle aged subjects from the Malmö Offspring...
162. P142 Androgen Receptor Reduced Sensitivity is Associated with Cardiovascular Mortality in Men with Type 2 Diabetes - A 14-year Follow up Study
Adrian Heald, Ghasem Yadegarfar, Mark Livingston, Helene Fachim, Ram Prakash Narayanan, Mark Lunt, Kirk Siddals, Gabriela Cortes, Martin Gibson, Rachelle Donn, Simon Anderson, Geoff Hackett, Hugh Jones
Pages: S178 - S179
Background: Hypogonadism associates with increased cardiovascular morbidity/mortality in type 2 diabetes mellitus (T2DM). Increasing CAG repeat number within exon 1 of the androgen receptor gene associates with increased androgen receptor resistance/insulin resistance . We here investigated the...
163. P144 Augmentation Index is not a Reliable Measure of Wave Reflections in Patients with Severe Aortic Stenosis
Stamatia Pagoulatou, Nikolaos Stergiopulos, Vasiliki Bikia, Georgios Rovas, Hajo Müller, Stéphane Noble, Dionysios Adamopoulos
Pages: S180 - S180
Background: Augmentation index (AIx) serves as an independent predictor of cardiovascular events and mortality. It is often clinically used as a measure of arterial stiffness and reflections, a practice that was recently challenged. In this work, we sought to investigate the association between AIx and...
164. P145 Central Hemodynamic Response to Lower Body Negative Pressure in Individuals with Down Syndrome
I Thessa, Sang Ouk Wee, Georgios Grigoriadis, Elizabeth Schroeder, Tracy Baynard, Bo Fernhall
Pages: S181 - S181
Introduction: Individuals with Down syndrome (DS) have autonomic dysfunction, which impacts heart rate and blood pressure regulation. Initial evidence also suggests an impaired ability to peripherally vasoconstrict during lower body negative pressure (LBNP). Given the relationship between vessel caliber...
165. P146 The Predictive Role of Arterial Stiffness in the Development of Acute Kidney Injury in Patients Undergoing Surgical Aortic Valve Replacement
Evangelia Sigala, Charalambos Vlachopoulos, Konstantinos Triantafyllou, Andreas Katsaros, Nikolaos Koumallos, Vasilios Lozos, Nikolaos Baikoussis, Ilias Kouerinis, Nikolaos Giakis, Demosthenous Michael, Dimitrios Terentes Printzios, Konstantinos Filis, Dimitrios Tousoulis
Pages: S182 - S182
Purpose/Background/Objectives: Acute kidney injury (AKI) is a serious postoperative complication. Increased arterial stiffness has been shown to be an independent risk factor for cardiovascular events. Our aim was to investigate whether arterial stiffness is a predictor of AKI in patients following surgical...
Daniele Brustolim, Lucelia Magalhaes, Yuri Oliveira Mariano, Vinicius Louzada Castro, João Victor Perrone, Joilson Jesus Barreto Júnior, Gabriela Valverde
Pages: S183 - S184
Extracellular and biochemical changes in the vessel contribute to the stiffening, this process is determinant for the increase of the Pulse Wave Velocity (PWV) and subsequent increase of the central and brachial arterial pressures [1,2]. These vascular alterations are denominated of TOD (target organ...
167. P148 The Administration of Green Tea Extract Improves Hemodynamic Parameters, Arterial Stiffness and Renal Function in Patients with Diabetic Nephropathy
Marycruz Barocio, Fernando Grover, Mayra Jiménez, Mariana Larios, Patricia Quezada, Jhonatan Trujillo, Ernesto Cardona, David Cardona, Carlos Ramos
Pages: S185 - S185
Purpose/Background/Objectives: Type 2 Diabetes Mellitus (T2DM) is a disease characterized by macro and microvascular complications, particularly, coronary heart disease, cerebrovascular disease and nephropathy [1–4]. The green tea extract has shown an anti-inflammatory effect (2), so this nutraceutical...
168. P149 The Relationship Between Insulin Resistance Scores Parameters and Chemerin in Diabetic and Obese Patients
Angela Cozma, Adriana Fodor, Vasile Negrean, Dorel Sampelean, Ionut Minciuna, Monica Oltean, Ionela Popovici, Sorina Coste, Alexandra Dadarlat, Dana Pop, Olga Hilda Orasan, Adela-Viviana Sitar-Taut
Pages: S186 - S186
Background: Chemerin represents a recently discovered chemokine influencing adipocyte function, lipolysis, apparently positively associated with insulin resistance. Purpose: To evaluate the relationship between chemerin-insulin resistance scores in obese/diabetic patients. Methods: 88 patients (66...
169. P150 Study of Heamodynamic and Macrocirculation Indices Between Uncontrolled Naïve Hypertensives and Well Controlled Diabetic Patients
Areti Triantafyllou, Nick Koletsos, Konstantina Dipla, Ioanna Zografou, Xristos Avgerinos, Stauros Papadopoulos, Alexandros-Savvas Zafeiridis, Stella Kritikou, Eugenia Gkaliagkousi, Andreas Zafeiridis, Stella Douma
Pages: S187 - S187
Introduction: Both Type II Diabetes mellitus (DM) and hypertension have been associated with an increased risk for cardiovascular disease and linked to impairments in micro- and macrocirculation. However, previous studies examining micro- and macrocirculation in DM mainly include patients with comorbid...
170. P151 Microvascular Dysfunction is Associated with Impaired Beta-cell Function: The Maastricht Study
Wenjie Li, Alfons Houben, Tos Berendschot, Carroll Webers, Abraham Kroon, Marleen van Greevenbroek, Carla van der Kallen, Ronald Henry, Simone Sep, Pieter Dagnelie, Nicolaas Schaper, Simone Eussen, Casper Schalkwijk, Miranda Schram, Coen Stehouwer
Pages: S188 - S188
Background: The pathophysiological mechanism underlying beta-cell dysfunction in type 2 diabetes (T2D) is not fully understood. Recent animal studies suggest that microvascular dysfunction (MVD) may lead to insufficient delivery of oxygen and nutrients to beta-cells as well as an attenuated delivery...
171. P152 Prediction of Death or Heart Failure-related Hospitalizations by Cardio-ankle Vascular Index (CAVI) and CAVI0
Bart Spronck, Jonathan Lee, Garrett Oldland, Mary Jo Obeid, Mahati Paravathaneni, Naga Vaishnavi Gadela, Armghan Ans, Gurpreet Singh, Rushik Bhuva, Scott Akers, Julio Chirinos
Pages: S189 - S190
Background: Arterial stiffness as measured by carotid-femoral pulse wave velocity (PWV) has been shown to predict cardiovascular events . However, PWV is blood pressure (BP) dependent [2,3] leading to the development of cardio-ankle vascular index (CAVI) as a more blood pressure-independent index...
172. P153 Radial-finger Pulse Wave Velocity as a Measure of Microvascular Stiffness: Feasibility and Response to Nitroglycerin
Catherine Fortier, Mohsen Agharazii, Charles-Antoine Garneau, Karine Marquis
Pages: S191 - S191
Background/Objectives: We previously demonstrated a different regional stiffness response of elastic and muscular arteries after the administration of nitroglycerin, leading to an alteration of aortic-brachial stiffness gradient. Regional stiffness of smaller arteries may respond differently to vasodilation...
173. P154 Effect of Vitamin D Deficiency on Insulin Induced Vasodilatation and Receptor Expression in Rat Model of Polycystic Ovary Syndrome
Bálint Bányai, Benko Rita, Tarszabó Róbert, Lajtai Krisztina, Horváth Eszter Mária, Várbíró Szabolcs
Pages: S192 - S192
In polycystic ovary syndrome (PCOS) hyperandrogenism and metabolic dysfunction increase cardiovascular risk. Vitamin D3 deficiency is a common comorbidity in PCOS. Our aim was to examine the alterations of insulin-induced vasodilation and receptor expression in rat aorta in a PCOS model. Methods: Female...