3.4 Micro- and Macro-Vascular Remodeling and Cognitive Function in Hypertension
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Background: Cerebral microvascular alterations and hypoperfusion have been associated to cognitive disorder and dementia. We hypothesized that there is a direct link between retinal arteriolar remodelling, as assessed non-invasively using adaptive optics, and cognitive cerebral impairment in hypertensive patients.
Methods: Hypertensive patients over 65 years old with or without mild cognitive impairment were recruited. Each patient had a cognitive evaluation with MMSE; a study of retinal vasculature with adaptative optics RTX1® Camera to measure WT, internal diameter (ID), wall-to-lumen ratio (WLR) and arterio-venous ratio (AVR); an aortic, cerebral and carotid MRI to study cerebral volumes and white matter hyper-intensities (WMH) and carotid/aortic backward/forward flow (BF/FF) and distensibility. Correlations between retinal and cerebral, carotid and aortic remodelling were analysed.
Results: 51 treated and controlled hypertensive patients, aged of 74 ± 5 years, 67% males, were able to achieve all exams. Among subjects with higher WLR, a significantly lower MMSE was found (p = 0.04). Eye-Brain: AVR and arteriolar ID coefficient of variation were inversely related to cerebral volumes (r = −0.61, p = 0.01 and r = −0.58, p = 0.02). Eye-Carotid: AVR and arteriolar ID coefficient of variation were directly and indirectly correlated with peak BF/FF, respectively (r = 0.47, p = 0.005; r = −0.39, p = 0.02). Eye-Aorta: WT and AVR were inversely correlated with ascending aorta distensibility (r = −0.48, p = 0.003; r = −0.47, p = 0.007).
Conclusion: In elderly hypertensives, arteriolar retinal remodelling represents a potential marker of early cerebral atrophy, which might be linked to a cerebral microcirculation remodelling. This hypothesis is supported by the association between retinal vascular remodelling and impaired carotid flow and aortic elastic properties.
- © 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
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Cite this article
TY - JOUR AU - Antonio Gallo AU - Etienne Charpentier AU - Thomas Dietenbeck AU - Antoine Dufay AU - Alban Redheuil AU - Marie Chupin AU - Olivier Hanon AU - Xavier Girerd AU - Nadjia Kachenoura PY - 2020 DA - 2020/02/15 TI - 3.4 Micro- and Macro-Vascular Remodeling and Cognitive Function in Hypertension JO - Artery Research SP - S24 EP - S24 VL - 25 IS - Supplement 1 SN - 1876-4401 UR - https://doi.org/10.2991/artres.k.191224.017 DO - 10.2991/artres.k.191224.017 ID - Gallo2020 ER -