Artery Research

Volume 25, Issue Supplement 1, December 2019, Pages S170 - S170

P129 Arterial Stiffness in Bicuspid or Tricuspid Aortic Valve Aortopathy Using Magnetic Resonance Imaging: Crossing the Physical and Hemodynamic limits?

Authors
Ariel Pascaner1, Sophia Houriez—Gombaud-Saintonge2, 3, Gilles Soulat4, Umit Gencer4, Thomas Dietenbeck2, Yasmina Chenoune3, Nadjia Kachenoura2, Elie Mousseaux4, Damian Craiem1, Emilie Bollache2, *
1IMETTYB – CONICET – Universidad Favaloro, Buenos Aires
2Sorbonne Université, INSERM, CNRS, Laboratoire d’Imagerie Biomédicale, Paris
3ESME Sudria Research Lab, Paris
4Hôpital Européen Georges-Pompidou, Paris
*Corresponding author. Email: emilie.bollache@inserm.fr
Corresponding Author
Emilie Bollache
Available Online 17 February 2020.
DOI
https://doi.org/10.2991/artres.k.191224.155How to use a DOI?
Abstract

Purpose: To provide a comprehensive assessment of aortic stiffness, through both local and regional distensibility and pulse wave velocity (PWV), in patients with either a tricuspid (TAV) or bicuspid (BAV) aortic valve and/or aortic dilation using MRI.

Methods: We included 18 patients with TAV and dilated ascending aorta (DTAV, 65 ± 14 years, 11 males), 19 patients with a non-stenotic BAV without severe regurgitation (55 ± 15 years, 17 males), both paired for age, gender and pressures to control groups. All subjects underwent thoracic aortic axial 2D+t and sagittal 3D+t velocity-encoded MRI and carotid applanation tonometry. Local ascending (AA) and descending (DA) aortic distensibility as well as aortic arch PWV were automatically measured from 2D+t data [1], while regional AA and DA PWV were calculated from 3D+t data [2].

Results: As expected, both DTAV and BAV groups showed significantly increased maximal aortic diameters when compared to their respective control group: 47 ± 5 vs 31 ± 3 mm and 44 ± 4 vs 31 ± 4 mm, respectively (p < 0.001). However, no significant changes were found in local and regional aortic stiffness indices between both patient groups and their matched controls (p ≥ 0.05).

Conclusion: 2D or 3D data-derived distensibility or PWV concomitantly and unexpectedly indicate that aortic stiffness was unchanged in patients with aortopathy when compared to matched healthy controls. Since fundamental laminal flow conditions and elastic properties driving Moens-Korteweg models are not reached in highly dilated aortas, the associated turbulent flow, local flow disorganization, changes in derived pressure gradients and flow-wall forces might be more suitable for an early discrimination of patients with valve/aneurismal disease.

Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Volume-Issue
25 - Supplement 1
Pages
S170 - S170
Publication Date
2020/02/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.2991/artres.k.191224.155How to use a DOI?
Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Ariel Pascaner
AU  - Sophia Houriez—Gombaud-Saintonge
AU  - Gilles Soulat
AU  - Umit Gencer
AU  - Thomas Dietenbeck
AU  - Yasmina Chenoune
AU  - Nadjia Kachenoura
AU  - Elie Mousseaux
AU  - Damian Craiem
AU  - Emilie Bollache
PY  - 2020
DA  - 2020/02/17
TI  - P129 Arterial Stiffness in Bicuspid or Tricuspid Aortic Valve Aortopathy Using Magnetic Resonance Imaging: Crossing the Physical and Hemodynamic limits?
JO  - Artery Research
SP  - S170
EP  - S170
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.155
DO  - https://doi.org/10.2991/artres.k.191224.155
ID  - Pascaner2020
ER  -