P37 Increased Pressure Dependency of Pulse Wave Velocity with Age

Andrii Boguslavskyi; Haotian Gu; Lingyun Fang; Ana Rita Cabrito Cobaco; Philip Chowienczyk

doi:10.2991/artres.k.191224.069

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Volume 25, Issue Supplement 1, December 2019, Pages S78 - S78

P37 Increased Pressure Dependency of Pulse Wave Velocity with Age

Authors

Andrii Boguslavskyi¹^{, *}, Haotian Gu², Lingyun Fang³, Ana Rita Cabrito Cobaco⁴, Philip Chowienczyk²

¹Guy’s and St Thomas’ NHS Foundation Trust

²British Heart Foundation Centre, King’s College London, London, UK

³Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

⁴King’s College Hospital NHS Foundation Trust, London, UK

^*Corresponding author. Email: andrii.boguslavskyi@kcl.ac.uk

Corresponding Author

Andrii Boguslavskyi

Available Online 15 February 2020.

DOI: 10.2991/artres.k.191224.069 How to use a DOI?
Abstract: Background: Arterial stiffness, as measured by pulse wave velocity (PWV) is dependent on arterial blood pressure but whether this dependence varies with age is unknown. The objective of this study was to determine to what degree pressure-dependence varies with age.

Methods: 83 heathy (43 females) normotensive volunteers from three different age groups (young: 18–30, middle aged: 31–55, older: 56–70 years) were recruited for this study. Aortic PWV (aPWV) was measured at different level of aortic transmural pressure (aTMP). aTMP was calculated as difference between mean arterial pressure and mouth pressure (which is almost equal to intrathoracic pressure). Acute modulation of aTMP was achieved by performing respiratory manoeuvres (Valsalva and Muller manoeuvres) against a mouthpiece with a small leak.

Results: aPWV was higher in older compare to younger subjects (6.6 ± 1.4 vs 5.3 ± 0.9 m/s, p < 0.001). Changes of aTMP in response to respiratory manoeuvres were similar across all age groups. However, changes of aPWV induced by acute modulation of aTMP were age-dependent, with aPWV increasing by 1.7 m/s per 10 mmHg increase in aTMP in older subjects compared to 0.4 m/s per 10 mmHg of aTMP change in younger subjects (p < 0.001).

Conclusion: Pressure-dependence of aPWV increases with age. This may contribute to the age related increased in aPWV and, if reversible, have important implications for therapeutic lowering of PWV through anti-hypertensive treatment.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal: Artery Research
Volume-Issue: 25 - Supplement 1
Pages: S78 - S78
Publication Date: 2020/02/15
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.191224.069 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Andrii Boguslavskyi
AU  - Haotian Gu
AU  - Lingyun Fang
AU  - Ana Rita Cabrito Cobaco
AU  - Philip Chowienczyk
PY  - 2020
DA  - 2020/02/15
TI  - P37 Increased Pressure Dependency of Pulse Wave Velocity with Age
JO  - Artery Research
SP  - S78
EP  - S78
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.069
DO  - 10.2991/artres.k.191224.069
ID  - Boguslavskyi2020
ER  -

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