P82 Impaired Skin Microvascular Function in Systemic Lupus Erythematosus
- 10.2991/artres.k.191224.112How to use a DOI?
Objectives: Alterations in skin microcirculation have been associated with damage in various microvascular beds . Endothelial dysfunction in microcirculation plays a central role in the pathophysiology of rheumatic diseases, contributing substantially to the increased cardiovascular risk of these patients. Laser speckle contrast analysis (LASCA) is a novel non-invasive technique that can be used to evaluate endothelial function of skin microcirculation . Previous studies have shown impaired skin endothelial function in patients with systemic sclerosis. To our knowledge, no previous study has evaluated skin microcirculation in patients with SLE using LASCA [3,4].
Design and Methods: Fifty-two individuals (25 SLE patients and 27 matched controls) were studied. In all subjects, forearm skin blood flow was recorded under standardized conditions using a laser speckle contrast imager (PeriCam PSI NR System, Perimed). Post-occlusive reactive hyperemia (PORH) was assessed following a standardized protocol and data were analyzed with signal processing software (PIMSoft, Perimed). The amplitude of PORH responses was expressed as a percentage increase between peak and baseline perfusion (%).
Results: There were no differences among the two groups in age, sex, body mass index and hypertension status. Post occlusion reperfusion in SLE patients, was significantly lower as compared to non-SLE controls (155.5 ± 53.1 vs 194.5 ± 40.5% respectively, p = 0.004).
Conclusion: Patients with SLE demonstrate impaired skin microvascular endothelial function, providing a link that could explain the increased cardiovascular risk that these patients bear.
- © 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
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- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Nikolaos Koletsos AU - Eugenia Gkaliagkousi AU - Antonios Lazaridis AU - Panagiota Anyfanti AU - Areti Triantafyllou AU - Konstantina Dipla AU - Panagiotis Dolgyras AU - Vasiliki Galanopoulou AU - Spyros Aslanidis AU - Stella Douma PY - 2020 DA - 2020/02/17 TI - P82 Impaired Skin Microvascular Function in Systemic Lupus Erythematosus JO - Artery Research SP - S125 EP - S125 VL - 25 IS - Supplement 1 SN - 1876-4401 UR - https://doi.org/10.2991/artres.k.191224.112 DO - 10.2991/artres.k.191224.112 ID - Koletsos2020 ER -