P150 Study of Heamodynamic and Macrocirculation Indices Between Uncontrolled Naïve Hypertensives and Well Controlled Diabetic Patients
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Introduction: Both Type II Diabetes mellitus (DM) and hypertension have been associated with an increased risk for cardiovascular disease and linked to impairments in micro- and macrocirculation. However, previous studies examining micro- and macrocirculation in DM mainly include patients with comorbid hypertension. Therefore, the aim of the study was to compare hemodynamic and vascular indices in DM and non-DM patients, independently of their hypertension status.
Materials and Methods: Fifty-seven DM patients and 79 non-DM participants were enrolled. Participants underwent physical examination, ambulatory BP monitoring and estimation of pulse wave velocity (PWV) and intima-media thickness (IMT). Resting hemodynamic parameters were assessed by impedance cardiography. Participants also performed a 3-min-submaximal isometric handgrip (30% MVC) with continuous beat-by-beat BP/HR assessment (Finapress). The double product (DP = systolic blood pressure* heart rate) during HG was calculated, as an index of myocardial stress.
Results: No differences were observed in age, BMI, and resting BP among groups. Patients with DM had significantly higher PWV and IMT (p < 0.01) but lower velocity (VI) and acceleration index (ACI) compared to non-DM individuals (p < 0.05). Hypertensives had significantly higher myocardial stress during exercise compared to normotensives, independently of the presence of diabetes.
Conclusion: Despite similar blood pressure levels in DM and non-DM groups, the DM patients had higher PWV and IMT than non-DM participants. There were no differences between patients with isolated adequately controlled DM or isolated hypertension in macrocirculation indices, suggesting a possible equal impact of the above diseases on the macrovascular network.
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Cite this article
TY - JOUR AU - Areti Triantafyllou AU - Nick Koletsos AU - Konstantina Dipla AU - Ioanna Zografou AU - Xristos Avgerinos AU - Stauros Papadopoulos AU - Alexandros-Savvas Zafeiridis AU - Stella Kritikou AU - Eugenia Gkaliagkousi AU - Andreas Zafeiridis AU - Stella Douma PY - 2020 DA - 2020/02/17 TI - P150 Study of Heamodynamic and Macrocirculation Indices Between Uncontrolled Naïve Hypertensives and Well Controlled Diabetic Patients JO - Artery Research SP - S187 EP - S187 VL - 25 IS - Supplement 1 SN - 1876-4401 UR - https://doi.org/10.2991/artres.k.191224.170 DO - 10.2991/artres.k.191224.170 ID - Triantafyllou2020 ER -