P52 The Long-term Effects of Transcatheter Aortic Valve Implantation on Aortic Stiffness
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Purpose/Background/Objectives: Aortic stiffness and hemodynamics are independent predictors of adverse cardiovascular events. Transcatheter aortic valve implantation (TAVI) is growingly used in high surgical risk patients with aortic valve stenosis. We sought to investigate the effect of TAVI on aortic stiffness.
Methods: Fifty-five high-risk patients (mean age 79.5 ± 8.8 years, 46% males) with severe symptomatic aortic stenosis undergoing TAVI were included. Arterial stiffness was estimated through carotid-femoral pulse wave velocity (cfPWV). Measurements were conducted prior to the implantation, at discharge and 1 year post-TAVI.
Results: Prior to the implantation, cfPWV was 7.5 ± 1.4 m/s for the overall population. There was a statistically significant increase in measurements of aortic stiffness at discharge (7.5 ± 1.4 vs 8.3 ± 1.9 m/s for cfPWV with p = 0.043) without a statistically significant change in SBP (p = NS) (Figure 1). There was also a significant increase in cfPWV (8.7 ± 1.8 m/s) after 1 year compared to the pre-procedural assessment (p = 0.001). We also observed a non-significant increase in peripheral SBP at 1 year compared to SBP measurements at baseline and at discharge (153 ± 24 m/s vs 147 ± 21and 148 ± 22 m/s, respectively; p = 0.319) and these changes were independent of age and gender (Figure 1).
Conclusion: Our study shows that both shortly as well as in the long-term after TAVI subjects experience an increase in aortic stiffness that is independent of changes in SBP. These findings further elucidate the hemodynamic consequences and provide evidence of a possible long-standing repercussion of TAVI.
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Cite this article
TY - JOUR AU - Vasiliki Gardikioti AU - Dimitrios Terentes-Printzios AU - Charalambos Vlachopoulos AU - Konstantinos Toutouzas AU - Evangelia Christoforatou AU - Maria Xanthopoulou AU - Georgios Benetos AU - Georgios Latsios AU - Gerasimos Siasos AU - Evangelia Mpei AU - Manolis Vavuranakis AU - Dimitrios Tousoulis PY - 2020 DA - 2020/02/17 TI - P52 The Long-term Effects of Transcatheter Aortic Valve Implantation on Aortic Stiffness JO - Artery Research SP - S93 EP - S93 VL - 25 IS - Supplement 1 SN - 1876-4401 UR - https://doi.org/10.2991/artres.k.191224.083 DO - 10.2991/artres.k.191224.083 ID - Gardikioti2020 ER -