P23 Tadalafil improves hemodynamic parameters and arterial stiffness in patients with grade I-II obesity without comorbidities
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Background: Obesity is a global health problem, it is associated with diabetes, hypertension, and cardiovascular diseases  and negative hemodynamic effects have been observed . Tadalafil has shown an improvement in endothelial function  the aim of the present investigation was to evaluate its effects on hemodynamic parameters in patients with grade I-II obesity.
Objective: To evaluate the acute effect of tadalafil on hemodynamic and arterial stiffness parameters.
Methods: A double blind clinical trial, randomized, was carried out in patients with grade I-II obesity. Seventy patients were allocated to receive placebo or a single dose of 20 mg of tadalafil; hemodynamic (Omron HEM 9000, UNEXEF) and arterial stiffness (Omrom VP1000) parameters were determined before and 24 hours after intervention. The values are expressed in mean ± SD. Wilcoxon rank test and U de Mann-Whitney were applied. p < 0.05 was considerated as statistically significant.
Results: Both groups were comparable in the baseline. After the intervention a statistically significant changes were shown in the tadalafil group in the diastolic blood pressure (DBP), (.001); second systolic shoulder 2 (SYS2), (.003); augmentation index (Aix), (.049); and braquial-ankle pulse wave velocity (BAPWV), (.005). After that, changes between groups were analyzed and only DBP (−2.39, p = .017) and BAPWV (p = .028) were statistically significant. No changes were observed in flow mediated dilatation (FMD).
Conclusion: Tadalafil modifies DBP and BAPWV but it had not effect on FMD in the acute administration.
- © 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
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Cite this article
TY - JOUR AU - Mariana Larios-Cardenas AU - Fernando Grover-Páez AU - David Cardona-Muller AU - Ernesto Cardona AU - Oscar I. Gonzalez-Radillo AU - Jonathan Trujillo-Quiros AU - Marycruz Barocio-Pantoja AU - Patricia Quezada-Fernandez AU - Carlos G. Ramos-Becerra PY - 2020 DA - 2020/02/15 TI - P23 Tadalafil improves hemodynamic parameters and arterial stiffness in patients with grade I-II obesity without comorbidities JO - Artery Research SP - S66 EP - S66 VL - 25 IS - Supplement 1 SN - 1876-4401 UR - https://doi.org/10.2991/artres.k.191224.057 DO - 10.2991/artres.k.191224.057 ID - Larios-Cardenas2020 ER -