P118 Arterial Stiffness in Patients with Arterial Hypertension on Short Term Dual Treatment with Fimasartan/Amlodipine
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Background: Pulse wave velocity (PWV) reflects arterial stiffness and is an independent predictor of cardiovascular mortality and morbidity. It is important to determine the effect dual therapy has on both BP and PWV.
Methods: A quasi-experimental study was performed in patients with grade 1 and 2 primary hypertension (HTN). Patients received the combination amlodipine/fimasartan (5 mg/60 mg/day) for 8 weeks. Anthropometric and hemodynamic measurements were made after a 2-week washout period and at week 8 of treatment. The brachial-ankle pulse wave velocity (baPWV), SBP, DBP, Pulse pressure (PP), central systolic blood pressure (cSBP) and the augmentation index normalized to 75 bpm (pAIx75) were measured.
Results: We included 42 patients (14 women) aged 56 ± 16 years. We observed a decrease in baVOP, 17.99 ± 2.80 m/s vs 16.14 ± 2.36 m/s, (p < 0.001); SBP 160 ± 18 mmHg vs 138 ± 14 mmHg (p < 0.001); DBP 96 ± 14 mmHg vs 82 ± 10 mmHg, (p < 0.001); PP 63 ± 18 mmHg vs 56 ± 14 mmHg, (p < 0.001); AIx75 85 ± 9% vs 80 ± 10%, (p = 0.002); and cSBP 151 ± 18 mmHg vs 128 ± 15 mmHg (p < 0.001). Before the treatment 71% patients had arterial stiffness and after the treatment only 33% of the patients had it, the BP goal of < 130/80 was achieved in only 16%.
Conclusion: The short term dual therapy with amlodipine/fimasartan significantly decreased baPWV, cSBP, PP, SBP, DBP and pAIx75. Only 16% of the patients achieved the BP goal with this treatment.
- © 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
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Cite this article
TY - JOUR AU - Brandon Giovany Illescas Vidrio AU - David Cardona Müller AU - Ernesto Germán Cardona Muñoz AU - Claudia Yanette Gálan Ruiz AU - Carlos Gerardo Ramos Becerra AU - Fernando Grover Páez PY - 2020 DA - 2020/02/17 TI - P118 Arterial Stiffness in Patients with Arterial Hypertension on Short Term Dual Treatment with Fimasartan/Amlodipine JO - Artery Research SP - S158 EP - S158 VL - 25 IS - Supplement 1 SN - 1876-4401 UR - https://doi.org/10.2991/artres.k.191224.144 DO - 10.2991/artres.k.191224.144 ID - IllescasVidrio2020 ER -