P50 The Administration of Losartan/Amlodipine in Fixed Combination Versus Losartan Improves the Hemodynamic and Arterial Stiffness Parameters in Patients with Systemic Hypertension Grade 1 and 2
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Purpose/Background/Objectives: Hypertension (HAS) represents 9.4 million deaths from all the cases of cardiovascular disease worldwide . The pulse wave velocity (PWV) and some hemodynamic parameters have been associated with this outcome [2,3]. Losartan, as well as amlodipine, have shown benefits on hemodynamic parameters [4,5] however, it is unknown if losartan/amlodipine combination is better than losartan as a monotherapy. We evaluated losartan/amlodipine effect in a fixed combination versus losartan on hemodynamic and arterial stiffness parameters in patients with systemic arterial hypertension.
Design and Methods: We conducted a randomized, double-blind study in 28 hypertensive patients according to AHA criteria 2017 . 14 patients received losartan 100 mg per day and 14 losartan/amlodipine 100/5 mg per day, for 8 weeks. Hemodynamic parameters and arterial stiffness measurement were performed with a Mobil-O-Graph® .
Results: The combination of losartan/amlodipine improved hemodynamic and arterial stiffness parameters compared with losartan, reducing peripheral vascular resistance (RVP) (0.10 ± 0.08 vs 0.05 ± 0.08), PWV (0.52 ± 0.45 vs 0.33 ± 0.359), daytime PWV (7.24 ± 0.90 vs 7.61 ± 1.03), nocturnal PWV (6.86 ± 0.96 vs 7.27 ± 1.17) and diastolic blood pressure (DBP) (11.21 ± 6.15 vs 5.92 ± 7.65).d)
Conclusion: We did not find differences between single or combined medication in terms of BP reduction. However, arterial stiffness parameters were better in the combined therapy.
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Cite this article
TY - JOUR AU - Mayra Jimenez AU - Fernando Grover AU - Marycruz Barocio AU - Ernesto Cardona AU - Patricia Quezada AU - Jhonatan Trujillo AU - David Cardona AU - Carlos Ramos PY - 2020 DA - 2020/02/17 TI - P50 The Administration of Losartan/Amlodipine in Fixed Combination Versus Losartan Improves the Hemodynamic and Arterial Stiffness Parameters in Patients with Systemic Hypertension Grade 1 and 2 JO - Artery Research SP - S91 EP - S91 VL - 25 IS - Supplement 1 SN - 1876-4401 UR - https://doi.org/10.2991/artres.k.191224.081 DO - 10.2991/artres.k.191224.081 ID - Jimenez2020 ER -