Artery Research

Volume 25, Issue Supplement 1, December 2019, Pages S113 - S113

P69 The Initial Upstroke Time is Most Strongly Associated with the Severity of as Among Brachial Pulse Wave Parameters

Authors
Masao Takahashi1, *, Kyohei Fukatani2, Tomoyuki Kabutoya3, Satoshi Hoshide3, Tatsuya Yoneyama4, Tetsuya Ito2, Kazuomi Kario3
1Department of Cardiovascular Medicine, Jichi Medical University, Shimotsuke, Japan
2Academic Promotion Section, Fukuda Denshi Co., Ltd.
3Jichi Medical University, Japan
4R&D Head Office, Fukuda Denshi Co., Ltd.
*Corresponding author. Email: md32144@gmail.com
Corresponding Author
Masao Takahashi
Available Online 17 February 2020.
DOI
10.2991/artres.k.191224.100How to use a DOI?
Abstract

Background: Aortic valve stenosis (AS) is the most common valve disease in an elderly population, therefore, simple screening examination for AS is needed. Although a prolonged carotid upstroke time (UT), and prolonged ejection time (ET) of a brachial pulse wave (BPW) have been observed in severe AS patients, it has been unclear which BPW parameters have a better correlation with the severity of AS. The aim of this study was to examine which BPW parameters are most relevant to the severity of AS.

Methods: Sixty-five Consecutive moderate and severe AS patients who were evaluated by trans-thoracic echocardiography were enrolled in this study. Control patients who were adjusted for age, gender, and blood pressure among outpatients were enrolled (N = 110). UT, ET, initial upstroke time (iUT), and half rise time of upstroke (1/2 hrUT) were evaluated correlations between mean pressure gradient (mPG) among AS patients.

Results: iUT and 1/2 hrUT have significant correlations with mPG among AS patients (iUT: R = 0.50, 95% CI = 0.29–0.67, p < 0.0001; 1/2 hrUT: R = 0.41, 95% CI = 0.19–0.60, p < 0.001), whereas UT and ET did not. Multivariate logistic regression analysis showed area under curve (AUC) of iUT and 1/2 hrUT were higher than UT and ET to predict mPG >40 mmHg (AUC: iUT vs 1/2 hrUT vs UT vs ET = 0.90 vs 0.89 vs 0.69 vs 0.77).

Conclusion: The severity of AS appeared strongly in the first half of the BPW upstroke. iUT and 1/2 hrUT may be a simple and useful screening test to assess the severity of AS.

Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Volume-Issue
25 - Supplement 1
Pages
S113 - S113
Publication Date
2020/02/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.191224.100How to use a DOI?
Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Masao Takahashi
AU  - Kyohei Fukatani
AU  - Tomoyuki Kabutoya
AU  - Satoshi Hoshide
AU  - Tatsuya Yoneyama
AU  - Tetsuya Ito
AU  - Kazuomi Kario
PY  - 2020
DA  - 2020/02/17
TI  - P69 The Initial Upstroke Time is Most Strongly Associated with the Severity of as Among Brachial Pulse Wave Parameters
JO  - Artery Research
SP  - S113
EP  - S113
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.100
DO  - 10.2991/artres.k.191224.100
ID  - Takahashi2020
ER  -