P135 Assessment of Novel Blood Pressure Corrected Cardio-ankle Vascular Index in Response to Acute Blood Pressure Changes
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Background: Cardio-ankle vascular index (CAVI) has long been considered a measure of arterial stiffness independent of short-term changes in blood pressure (BP) . Recently and theoretically, CAVI was found to be partially affected by actual BP, thus, a novel BP-corrected index, CAVI0, was proposed to diminish these effects [2,3]. Direct, repeated measures experimental data comparing CAVI’s and CAVI0’s acute blood pressure dependence is lacking. Hence, the aim of this study was to assess the effects of short-term changes of BP on CAVI0 in comparison with standard CAVI.
Methods: 60 healthy adults were examined using vascular screening system VaSera 1500 N (Fukuda Denshi Co., Tokyo, Japan) during four examination periods lasting 5 minutes – baseline, cold pressor test (CPT), recovery period, and isometric handgrip exercise (IHE). CAVI and cardiovascular parameters for calculation of CAVI0 were measured after baseline, at the peak of pressor response to CPT, after recovery period, and at the peak of pressor response to IHE. CAVI, CAVI0, and mean BP were assessed for all periods.
Results: CAVI significantly increased during CPT compared to baseline rest (p = 0.008), returned to baseline values during recovery period (p = 0.011 compared to CPT), and significantly increased during IHE compared to recovery period (p = 0.002). No significant changes of CAVI0 were found. CAVI significantly correlated with changes in mean BP (p = 0.012; multilevel regression); CAVI0 did not (p = 0.570).
Conclusion: In this repeated measures, experimental, acute study, CAVI showed short-term blood pressure dependence, whereas CAVI0 did not.
- © 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
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- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Michal Mestanik AU - Bart Spronck AU - Alexander Jurko AU - Andrea Mestanikova AU - Tomas Jurko AU - Mark Butlin AU - Alberto Avolio AU - Lucia Bona Olexova AU - Zuzana Visnovcova AU - Nikola Sekaninova AU - Ingrid Tonhajzerova PY - 2020 DA - 2020/02/17 TI - P135 Assessment of Novel Blood Pressure Corrected Cardio-ankle Vascular Index in Response to Acute Blood Pressure Changes JO - Artery Research SP - S173 EP - S173 VL - 25 IS - Supplement 1 SN - 1876-4401 UR - https://doi.org/10.2991/artres.k.191224.158 DO - 10.2991/artres.k.191224.158 ID - Mestanik2020 ER -