P90 Indexing Left Ventricular Mass to Body Size: Which Method is the Most Appropriate in Early Adulthood?
- DOI
- 10.2991/artres.k.191224.120How to use a DOI?
- Abstract
Introduction: Left ventricular mass (LVM) predicts cardiovascular risk. In early life, LVM is conventionally indexed to height 2.7 [1], although this may not account for sex differences in growth. We investigated allometric scaling of LVM to height, lean mass (LM) and body surface area (BSA) in a UK birth cohort.
Methods: 861 individuals underwent echocardiography to assess LVM at age 17.7 (SD 0.3) years and 24.0 (SD 0.6) years. LM was quantified using dual-energy X-ray absorptiometry. Group and sex-specific allometric relationships were determined by linear regression, following log transformation of x and y variables (log(y) = a + b * log(x)) (b = scaling exponent).
Results: LVM showed a linear relationship with LM and log(height), although the intercepts differed by sex. At age 17, the exponent relating LVM to height in males and females combined was 2.67 (95% CI: 2.41, 2.91), very close to the suggestion of height 2.7. Sex-specific estimates for height were lower and close to the estimate of 1.7 [2], at 1.77 (1.17, 2.37) and 1.83 (1.35, 2.31), for males and females, respectively. The female exponent at age 24 remained close to 1.7, while the male exponent increased to 2.14 (1.54, 2.73). Exponents for LM and BSA remained similar between ages 17 and 24 (see Table 1 for detail).
Conclusion: A universal approach for allometric indexing of LVM may be inappropriate in early adulthood, and indexation may need to be both age- and gender-specific. It remains unclear which indexing method is superior at these ages, although height may be unsuitable. These observations may have important implications for identifying young individuals with cardiac hypertrophy.
Height Lean BSA n Coefficient (+ 95% CI) p n Coefficient (+ 95% CI) p n Coefficient (+ 95% CI) p Age 17 Group 861 2.67 (2.41, 2.91) <0.001 861 0.85 (0.80, 0.91) <0.001 861 1.76 (1.64, 1.88) <0.001 Male 333 1.77 (1.17, 2.37) <0.001 333 1.18 (1.00, 1.36) <0.001 333 1.69 (1.45, 1.93) <0.001 Female 528 1.83 (1.35, 2.31) <0.001 528 1.10 (0.96, 1.24) <0.001 528 1.36 (1.20, 1.53) <0.001 Age 24 Group 861 2.97 (2.70, 3.23) <0.001 861 1.07 (1.01, 1.13) <0.001 861 1.78 (1.66, 1.90) <0.001 Male 333 2.14 (1.54, 2.73) <0.001 333 1.20 (1.05, 1.35) <0.001 333 1.60 (1.36, 1.84) <0.001 Female 528 1.65 (1.11, 2.19) <0.001 528 1.10 (0.98, 1.23) <0.001 528 1.32 (1.15, 1.50) <0.001 - Copyright
- © 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
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TY - JOUR AU - Hannah Taylor AU - Chloe Park AU - Abigail Fraser AU - Laura Howe AU - Dianna Ferreira AU - Nic Timpson AU - Debbie Lawlor AU - George Davey-Smith AU - Nishi Chaturvedi AU - Alun Hughes PY - 2020 DA - 2020/02/17 TI - P90 Indexing Left Ventricular Mass to Body Size: Which Method is the Most Appropriate in Early Adulthood? JO - Artery Research SP - S133 EP - S133 VL - 25 IS - Supplement 1 SN - 1876-4401 UR - https://doi.org/10.2991/artres.k.191224.120 DO - 10.2991/artres.k.191224.120 ID - Taylor2020 ER -