P107 Endothelial Dysfunction Associated with Arterial Stiffness in Postmenopausal Women with Obesity

Patricia Lizette Ramírez Soltero; Leonel García Benavides; Marycruz Barocio Pantoja; Brandon Giovanni Illescas Vidrio; David Cardona Müller; Ernesto Germán Cardona Muñoz; Sylvia Elena Totsuka Sutto

doi:10.2991/artres.k.191224.133

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Volume 25, Issue Supplement 1, December 2019, Pages S147 - S147

P107 Endothelial Dysfunction Associated with Arterial Stiffness in Postmenopausal Women with Obesity

Authors

Patricia Lizette Ramírez Soltero¹^{, *}, Leonel García Benavides², Marycruz Barocio Pantoja¹, Brandon Giovanni Illescas Vidrio¹, David Cardona Müller¹, Ernesto Germán Cardona Muñoz¹, Sylvia Elena Totsuka Sutto¹

¹Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico

²Department of Physiology, University Center Tonalá, University of Guadalajara, Guadalajara, Mexico

^*Corresponding author. Email: lizramsol@hotmail.com

Corresponding Author

Patricia Lizette Ramírez Soltero

Available Online 17 February 2020.

DOI: 10.2991/artres.k.191224.133 How to use a DOI?
Abstract: Background: Endothelial dysfunction (ED) represents an initial step of “vascular failure” [1]; several factors affect the functionality of the endothelium. Obesity [2] and estrogen deficiency [3] are independently associated with this. The early detection of ED is essential to intervene and prevent its progression. One of the most promising methods to assess vascular endothelial function is the measurement of endothelium- dependent flow-mediated vasodilation (FMD) [1]. Similarly, pulse wave velocity (PWV) is considered as a predictive value for the stratification of vascular risk [4], however, progression between endothelial events and arterial stiffness continues to be examined.

Objective: To evaluate the association between endothelial dysfunction and arterial stiffness in postmenopausal women with obesity.

Methods: Descriptive study of 19 postmenopausal women with grade I and II obesity, without associated comorbidities. Participants were classified into one of two groups: with ED (FMD < 6%) or non-ED (FMD > 6%). The hemodynamic metabolic, hormonal and arterial stiffness parameters were evaluated.

Results: The group with ED (n = 10) compared to the non-ED group (n = 9) presented age 57.30 ± 4.80 vs 52.40 ± 5.70 years (p = NS); BMI 34.75 ± 2.06 vs 33.06 ± 2.51 kg/m² (p = NS). Statically significant findings include: FSH 35.43 ± 11.04 vs 55.19 ± 19.27 mUI/ml (p = 0.018); PWV 9.18 ± 1.84 vs 7.52 ± 1.26 m/s (p = 0.041); central SBP 135 ± 15.90 vs 120 ± 18.2 mmHg (p = 0.041). We also measure estradiol, QIMT, SBP, DBP, PP, AIx, LDL-C, HDL-C and triglycerides, no significant differences were observed.

Conclusion: We can conclude that in the group with endothelial dysfunction the PWV and the cSBP are higher with a significant difference.
Copyright: © 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

References

[1]T Inoue, H Matsuoka, Y Higashi, S Ueda, M Sata, KE Shimada, et al., Flow-mediated vasodilation as a diagnostic modality for vascular failure, Hypertens Res, Vol. 31, 2008, pp. 2105-13.

[2]A Engin, Endothelial dysfunction in obesity, Adv Exp Med Biol, Vol. 960, 2017, pp. 345-79.

[3]YB Somani, JA Pawelczyk, MJ De Souza, PM Kris-Etherton, and DN Proctor, Aging women and their endothelium: Probing the relative role of estrogen on vasodilator function, Am J Physiol Heart Circ Physiol, Vol. 317, 2019, pp. H395-H404.

[4]L Engelen, J Bossuyt, I Ferreira, LM van Bortel, KD Reesink, P Segers, et al., Reference values for local arterial stiffness. Part A: carotid artery, J Hypertens, Vol. 33, 2015, pp. 1981-96.

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Journal: Artery Research
Volume-Issue: 25 - Supplement 1
Pages: S147 - S147
Publication Date: 2020/02/17
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.191224.133 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Patricia Lizette Ramírez Soltero
AU  - Leonel García Benavides
AU  - Marycruz Barocio Pantoja
AU  - Brandon Giovanni Illescas Vidrio
AU  - David Cardona Müller
AU  - Ernesto Germán Cardona Muñoz
AU  - Sylvia Elena Totsuka Sutto
PY  - 2020
DA  - 2020/02/17
TI  - P107 Endothelial Dysfunction Associated with Arterial Stiffness in Postmenopausal Women with Obesity
JO  - Artery Research
SP  - S147
EP  - S147
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.133
DO  - 10.2991/artres.k.191224.133
ID  - RamírezSoltero2020
ER  -

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