P107 Endothelial Dysfunction Associated with Arterial Stiffness in Postmenopausal Women with Obesity
- 10.2991/artres.k.191224.133How to use a DOI?
Background: Endothelial dysfunction (ED) represents an initial step of “vascular failure” ; several factors affect the functionality of the endothelium. Obesity  and estrogen deficiency  are independently associated with this. The early detection of ED is essential to intervene and prevent its progression. One of the most promising methods to assess vascular endothelial function is the measurement of endothelium- dependent flow-mediated vasodilation (FMD) . Similarly, pulse wave velocity (PWV) is considered as a predictive value for the stratification of vascular risk , however, progression between endothelial events and arterial stiffness continues to be examined.
Objective: To evaluate the association between endothelial dysfunction and arterial stiffness in postmenopausal women with obesity.
Methods: Descriptive study of 19 postmenopausal women with grade I and II obesity, without associated comorbidities. Participants were classified into one of two groups: with ED (FMD < 6%) or non-ED (FMD > 6%). The hemodynamic metabolic, hormonal and arterial stiffness parameters were evaluated.
Results: The group with ED (n = 10) compared to the non-ED group (n = 9) presented age 57.30 ± 4.80 vs 52.40 ± 5.70 years (p = NS); BMI 34.75 ± 2.06 vs 33.06 ± 2.51 kg/m2 (p = NS). Statically significant findings include: FSH 35.43 ± 11.04 vs 55.19 ± 19.27 mUI/ml (p = 0.018); PWV 9.18 ± 1.84 vs 7.52 ± 1.26 m/s (p = 0.041); central SBP 135 ± 15.90 vs 120 ± 18.2 mmHg (p = 0.041). We also measure estradiol, QIMT, SBP, DBP, PP, AIx, LDL-C, HDL-C and triglycerides, no significant differences were observed.
Conclusion: We can conclude that in the group with endothelial dysfunction the PWV and the cSBP are higher with a significant difference.
- © 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
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- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Patricia Lizette Ramírez Soltero AU - Leonel García Benavides AU - Marycruz Barocio Pantoja AU - Brandon Giovanni Illescas Vidrio AU - David Cardona Müller AU - Ernesto Germán Cardona Muñoz AU - Sylvia Elena Totsuka Sutto PY - 2020 DA - 2020/02/17 TI - P107 Endothelial Dysfunction Associated with Arterial Stiffness in Postmenopausal Women with Obesity JO - Artery Research SP - S147 EP - S147 VL - 25 IS - Supplement 1 SN - 1876-4401 UR - https://doi.org/10.2991/artres.k.191224.133 DO - 10.2991/artres.k.191224.133 ID - RamírezSoltero2020 ER -