5.6 Aortic Pressure Behind Flow Disorganization in Aneurismal Aorta: a Magnetic Resonance Imaging Study

DOI

10.2991/artres.k.191224.035How to use a DOI?

Abstract

Purpose: Understanding and prediction of ascending thoracic aortic aneurysms (ATAA) progression are not well established yet and aortic dissection is frequently occurring on normally sized and mildly dilated aortas. Despite known theoretical associations between pressures and blood flow patterns there are no studies focusing on their simultaneous evaluation. Our aim was to propose a comprehensive and quantitative evaluation of pressure-flow-wall interplay from 4D flow MRI in the setting of aortic dilation.

Methods: We studied 12 patients with ATAA (67 ± 14 years, 7 males) and 12 healthy subjects (63 ± 12 years, 8 males) who underwent 4D flow MRI. The segmented velocity fields were used to estimate: 1) local ascending aorta (AA) pressure changes from Navier-Stokes-derived relative pressure maps (AADP, mmHg), 2) AA wall shear stress (AAWSS, Pa) by estimating local velocity derivatives at the aortic borders, 3) aortic flow vorticity using the λ2 method (AAV, s-1).

Results: AA local pressure change (AADP) was significantly associated with both AAV (r = 0.55, p = 0.006) and AAWSS (r = 0.69, p < 0.001) and both associations remained significant after adjustment for diameter, age and BSA (p = 0.007 and p = 0.003 respectively). Such positive associations indicate that local pressure variations affect local blood flow, generating flow current from high to low pressures and subsequently vortices with the underlying stress exerted on the AA wall.

Conclusion: Local variations in aortic pressures, measured using 4D flow MRI, are associated with flow disorganization as quantified by vorticity and with the increase in the stress exerted on the aortic wall, as quantified by wall shear stress.

Copyright

© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

TY  - JOUR
AU  - Kevin Bouaou
AU  - Thomas Dietenbeck
AU  - Gilles Soulat
AU  - Sophia Houriez—Gombaud-Saintonge
AU  - Ioannis Bargiotas
AU  - Alain De Cesare
AU  - Umit Gencer
AU  - Alain Giron
AU  - Alban Redheuil
AU  - Emilie Bollache
AU  - Didier Lucor
AU  - Elie Mousseaux
AU  - 
 Nadjia Kachenoura
PY  - 2020
DA  - 2020/02/15
TI  - 5.6 Aortic Pressure Behind Flow Disorganization in Aneurismal Aorta: a Magnetic Resonance Imaging Study
JO  - Artery Research
SP  - S42
EP  - S42
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.035
DO  - 10.2991/artres.k.191224.035
ID  - Bouaou2020
ER  -