P17 Comparisons of Carotid-femoral Pulse Wave Velocity Obtained from the Surface-distance Measurement and from the Population-derived Distance Formula: Associations with Macro- and Microvascular Alterations in Older Adults

DOI

10.2991/artres.k.191224.051How to use a DOI?

Abstract

Introduction: Inaccurate determination of arterial path-length by surface-distance (SD) measurement is an inherent source of error in calculating carotid-femoral pulse wave velocity (CFPWV). A recent development in calculating arterial path-length by a simple distance formula (DF) for CFPWV has been shown to not only remove intercentre measurement variability but also strengthen the association between CFPWV and traditional cardiovascular risk factors [1]. We determined whether the association of macro- and microvascular alterations with CFPWV derived from the distance formula (CFPWV-DF) would be stronger than that with CFPWV derived from the surface-distance measurement (CFPWV-SD).

Methods: CFPWV-DF and CFPWV-SD were obtained from 489 older adults (67.2 ± 8.8 yrs, 154 F, 244 CVD). Macrovascular [carotid lumen diameter (LD), carotid inter-adventitial diameter (IAD), carotid intima-media thickness (IMT), carotid total plaque area, and ankle-brachial pressure index] and microvascular [reactive hyperaemia index and urinary albumin-creatinine ratio (UACR)] parameters were also obtained.

Results: CFPWV-DF was significantly lower than CFPWV-SD (9.27 ± 2.38 vs 9.88 ± 2.55 m/s, p < 0.001), which resulted from a longer arterial path-length estimated by SD than DF (495.4 ± 44.8 vs 465.3 ± 20.6 mm, p < 0.001). The significant associations observed between CFPWV-SD and LD (r = 0.264), IAD (r = 0.303), and IMT (r = 0.165) were similarly observed between CFPWV-DF and LD (r = 0.253), IAD (r = 0.303), and IMT (r = 0.183, all p < 0.001). This was also the case with UACR (r = 0.163 and r = 0.141, both p = 0.001). Other parameters did not show any association in either CFPWV.

Conclusion: The association of macro- and microvascular alterations with CFPWV-DF was not stronger than that with CFPWV-SD, suggesting that arterial path-length determination methods may not influence interactions between vascular biomarkers and CFPWV.

Copyright

© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Kunihiko Aizawa
AU  - Francesco Casanova
AU  - Dave Mawson
AU  - Kim Gooding
AU  - Salim Elyas
AU  - Damilola Adingupu
AU  - David Strain
AU  - Phillip Gates
AU  - Angela Shore
PY  - 2020
DA  - 2020/02/15
TI  - P17 Comparisons of Carotid-femoral Pulse Wave Velocity Obtained from the Surface-distance Measurement and from the Population-derived Distance Formula: Associations with Macro- and Microvascular Alterations in Older Adults
JO  - Artery Research
SP  - S60
EP  - S60
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.051
DO  - 10.2991/artres.k.191224.051
ID  - Aizawa2020
ER  -