Monoclonal Antibodies in Oncology and their Effect on Arterial Stiffness – A Systematic Review

DOI

10.2991/artres.k.200323.001How to use a DOI?

Keywords

Monoclonal antibodies; anticancer treatment; cardiotoxicity; arterial stiffness; arterial inflammation; pulse wave velocity

Abstract

Introduction: Malignancies are the second leading cause of death worldwide. Treatment Monoclonal Antibody (MAbs)-based treatment of cancer has been established as one of the most successful therapeutic strategies in the last 20 years; however, there is a growing concern about the effects of these agents on patients’ cardiovascular profile.

Areas Covered: In this manuscript we summarize current evidence regarding MAb effects on arterial stiffness, which is an recognised biomarker of cardiovascular risk. For this purpose, we explored two bibliographic databases [PubMed, Scopus] and one full-text database (Google-Scholar) for all publications published on MAbs’ effects on arterial stiffness until December 2019. Only few of the monoclonal antibody agents used in oncology have been investigated as per their effects on arterial properties and this limited evidence suggests that cancer therapy with monoclonal antibodies demonstrates either a temporary or long-term increase in arterial stiffness.

Discussion: It seems that by targeting ‘checkpoints’ in cancer genesis, anticancer MAbs also affects vascular properties causing endothelial dysfunction and arterial stiffness. Furthermore, several MAbs cause hypertension and may as a result increase pulse wave velocity. On the other hand, MAbs that target inflammatory cytokines seem to improve cardiovascular survival however, their effect on arterial stiffness is yet to be investigated. Further research is warranted in order to elucidate the biochemical pathways, clinical implications and potential reversibility of monoclonal antibody chemotherapy-induced vascular dysfunction.

Copyright

© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Eirini Solomou
AU  - Konstantinos Aznaouridis
AU  - Dimitrios Terentes-Printzios
AU  - Maria Drakopoulou
AU  - Konstantinos Toutouzas
AU  - Dimitris Tousoulis
AU  - Charalambos Vlachopoulos
PY  - 2020
DA  - 2020/04/18
TI  - Monoclonal Antibodies in Oncology and their Effect on Arterial Stiffness – A Systematic Review
JO  - Artery Research
SP  - 137
EP  - 142
VL  - 26
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.200323.001
DO  - 10.2991/artres.k.200323.001
ID  - Solomou2020
ER  -