Artery Research

Volume 7, Issue 3-4, September 2013, Pages 142 - 142

P4.25 COMPARISON BETWEEN EFFECTS OF BEZAFIBRATE AND EICOSAPENTAENOIC ACID ON ARTERIAL STIFFNESS MONITORING WITH CARDIO-ANKLE VASCULAR INDEX

Authors
Takashi Yamaguchi1, Saiki Atsuhito1, Tatsuno Ichiro1, Shirai Kohji2
1Center of Diabetes, Endocrine and metabolism, Sakura Hospital, Chiba, Japan
2Dept. Vascular function, Sakura Hospital, Toho UNIV., Chiba, Japan
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.143How to use a DOI?
Abstract

Background: Bezafibrate and Eicosapentanoic acid (EPA) were known to decrease serum triglyceride. And, EPA administration for 5 years was reported to improve cardiovascular events by JLIT study. Cardio-ankle vascular index (CAVI) was a new index reflecting arterial stiffness from the origin of the aorta to the ankle, and is reported to be a predictor of cardiac events or death rate of cardiovascular events. But, the effects of both agents on arterial stiffness were not fully clarified.

Object: The purpose of this paper is to clarify the effect of bezafibrate and EPA on the arterial stiffness monitored with CAVI in the type 2 diabetic patients with hypertriglyceridemia.

Subjects and methods: Eighty type 2 diabetic outpatients with hypertriglyceridemia were randomly divided into two groups: bezafibrate (BEZA; 400mg/day) and EPA (1800mg/day) groups and took each treatment for 6 months. Glucose and lipid metabolism, d-ROMs; an oxidative stress marker were also studied. CAVI was measured using Vasela1500 (Fukuda Denshi. Co.LTD).

Results: After 6 month treatment, blood pressure, LDL-cholesterol (LDL-C), CK were not significantly changed comparing with before values, in both groups. Triglyceride (TG) and remnant-like particle cholesterol decreased significantly in both groups, and there were no significant differences between groups. HDL-C, Apo A-1 increased and HbA1C, d-ROMs decreased significantly only in BEZA group. CAVI decreased by 0.1 in EPA group (not significant) and by 0.5 in BEZA group (p<0.005). There was a significant difference in the changes of CAVI between both groups (p<0.05). In BEZA group, there were no significant correlations between changes of CAVI and the changes of the other parameters.

Conclusion: Bezafibrate administration improved arterial stiffness monitored with CAVI significantly, whereas EPA administration did not changed CAVI, in type 2 diabetic patients with hypertriglyceridemia.

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Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
142 - 142
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.143How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Takashi Yamaguchi
AU  - Saiki Atsuhito
AU  - Tatsuno Ichiro
AU  - Shirai Kohji
PY  - 2013
DA  - 2013/11/11
TI  - P4.25 COMPARISON BETWEEN EFFECTS OF BEZAFIBRATE AND EICOSAPENTAENOIC ACID ON ARTERIAL STIFFNESS MONITORING WITH CARDIO-ANKLE VASCULAR INDEX
JO  - Artery Research
SP  - 142
EP  - 142
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.143
DO  - 10.1016/j.artres.2013.10.143
ID  - Yamaguchi2013
ER  -