Artery Research

Volume 26, Issue Supplement 1, December 2020, Pages S86 - S87

P.63 Sarcopenia and Atherosclerotic Occlusive Disease: How Much We Know and What We Need to Know About this Association?

Authors
Joana Ferreira1, 2, 3, *, Alexandre Carneiro4, Pedro Cunha2, 3, 5, 6, Armando Mansilha7, 8, Isabel Vila2, 3, 5, 6, Cristina Cunha2, 3, 5, 6, Cristina Silva2, 3, 5, 6, Adhemar Longatto-Filho2, 6, 9, 10, 11, Maria Correia-Neves2, 9, Gustavo Soutinho12, Luís Meira-Machado13, Amilcar Mesquita1, Jorge Cotter2, 3, 5, 6
1Vascular Surgery Department- Hospital da Senhora da Oliveira
2Life and Health Science Research Institute (ICVS), School of Medicine, University of Minho
3ICVS/3B’s-PT Government Associate Laboratory
4Radiology Department- ULSAM
5Medicine Department- Hospital da Senhora da Oliveira
6Center for the Research and Treatment of Arterial Hypertension and Cardiovascular Risk, Internal Medicine Department- Hospital da Senhora da Oliveira
7Faculdade de Medicina da Universidade do Porto
8Vascular Surgery Department Hospital de São João
9ICVS/3B’s-PT Government Associate Laboratory
10Department of Pathology (LIM-14), University of São Paulo School of Medicine
11Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos
12Institute of Public Health of the University of Porto (ISPUP)-University of Porto
13Centre of Molecular and Environmental Biology & Department of Mathematics-University of Minho
*Corresponding author. Email: joana222@gmail.com
Corresponding Author
Joana Ferreira
Available Online 31 December 2020.
DOI
10.2991/artres.k.201209.072How to use a DOI?
Keywords
Sarcopenia; strength; atherosclerosis
Abstract

Purpose/Background: Sarcopenia (decrease of muscle mass and function) has been linked with atherosclerosis [1]. The EWGSOP2 updated consensus, uses low muscle strength as the primary indicator of sarcopenia [2]. It is acknowledged that strength is better than mass for predicting adverse outcomes [2]. Handgrip strength (HGS) is a simple assessment to estimate overall muscular strength [3]. and is associated with cardiovascular mortality [4].

Objective: Analyze the relationship between HGS and atherosclerotic disease (carotid artery disease + lower extremity artery disease).

Methods: Prospective observation study was conducted from January to December 2019. The clinical and demographic data was recorded. Isometric HGS was measured with an adjustable handheld dynamometer (Jamar The higher value of each arm was used to classify the patient as sarcopenic or non-sarcopenic. Definition of sarcopenia: HGS <30 kgf in men and <20 kgf in women [5].

Results: 94 patients (aged 44–86 years) were analyzed: 64 sarcopenic and 30 non sarcopenic. Groups differed in the prevalence of diabetes and smoking status (Table 1). No differences were found in the carotid parameters analyzed (Table 1). There was, a difference in the prevalence of chronic limb-threatening ischemia (CLTI) in sarcopenic versus non-sarcopenic group (23.44% versus 6.67% p = 0.046). Importantly, binary logistic regression showed that diabetes (p = 0.014), and HGS (p = 0.027) have a significant effect on CLTI (Table 2).

Sarcopenia (n = 64) No Sarcopenia (n = 30) p
Age (years) 69.81 ± 8.79 62.6 ± 8.61 p = 0.889
Male 47 (73.44%) 27 (90.00%) p = 0.067
Hypertension 51 (79.69%) 21 (70.00%) p = 0.301
Dyslipidemia 47 (73.43%) 18 (60.00%) p = 0.189
Smoking load (UMA) 24.42 ± 33.14 37.76 ± 31.8 p = 0.748
Smoker/Ex-smoker 33 (51.56%) 24 (80.00%) p = 0.013*
Diabetes 28 (43.75%) 7 (23.33%) p = 0.049*
Coronary disease 11 (17.19%) 4 (13.33%) p = 0.613
History of stroke 11 (17.19%) 3 (10.00%) p = 0.347
Total cholesterol (mg/dL) 158.16 ± 39.82 159.6 ± 30.72 p = 0.22
LEAD 43 (67.19%) 17 (56.67%) p = 0.275
Claudicants 28 (43.75%) 15 (50.00%) p = 0.615
CLTI 15 (23.44%) 2 (6.67%) p = 0.046*
ABI right 0.83 ± 0.24 0.78 ± 0.29 p = 0.287
ABI left 0.81 ± 0.28 0.77 ± 0.23 p = 0.671
Right carotid artery stenosis
50–70 4 (6.25%) 2 (6.67%) p = 0.952
>70% 58 (90.63%) 27 (90.00%) p = 0.702
Light carotid artery stenosis
50–70 3 (4.79%) 1 (3.33%) p = 0.787
>70% 4 (6.25%) 2 (6.67%) p = 0.903
Area right carotid plaque (mm2) 21.22 ± 19.81 20.01 ± 17.04 p = 0.622
Average IMT- right (mm) 0.96 ± 0.41 0.88 ± 0.24 p = 0.159
Area left carotid plaque (mm2) 21.46 ± 18.73 21.47 ± 22.06 p = 0.948
Average IMT- left (mm) 0.93 ± 0.25 0.88 ± 0.29 p = 0.861
Independent variables Categories β 95% CI p
CLTI Diabetes 1.488 1.34–14.60 0.014
Higher HGS −0.888 0.846–0.990 0.027

Conclusions: No relationship was found between sarcopenia (measured by HGS) and carotid atherosclerosis, differing from other authors [1,6]. In this study, sarcopenic had a higher incident of diabetes and CLTI. Sarcopenia and diabetes are reciprocally related and may share a similar pathogenetic pathway [7,8,9].

Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

REFERENCES

Journal
Artery Research
Volume-Issue
26 - Supplement 1
Pages
S86 - S87
Publication Date
2020/12/31
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.201209.072How to use a DOI?
Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Joana Ferreira
AU  - Alexandre Carneiro
AU  - Pedro Cunha
AU  - Armando Mansilha
AU  - Isabel Vila
AU  - Cristina Cunha
AU  - Cristina Silva
AU  - Adhemar Longatto-Filho
AU  - Maria Correia-Neves
AU  - Gustavo Soutinho
AU  - Luís Meira-Machado
AU  - Amilcar Mesquita
AU  - Jorge Cotter
PY  - 2020
DA  - 2020/12/31
TI  - P.63 Sarcopenia and Atherosclerotic Occlusive Disease: How Much We Know and What We Need to Know About this Association?
JO  - Artery Research
SP  - S86
EP  - S87
VL  - 26
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201209.072
DO  - 10.2991/artres.k.201209.072
ID  - Ferreira2020
ER  -