Artery Research

Volume 26, Issue Supplement 1, December 2020

Conference Abstract

1. YI 1.1 Aortic Impedance and Total Arterial Compliance from Regional Pulse Wave Velocities

Vasiliki Bikia, Georgios Rovas, Stamatia Pagoulatou, Nikolaos Stergiopulos
Pages: S1 - S1
Background: In-vivo assessment of aortic characteristic impedance (Zao) and total arterial compliance (CT) has been hampered by the need for invasive methods to access simultaneous recordings of aortic pressure and flow, wall thickness, and cross-sectional area. In contrast, regional pulse wave velocity...
Conference Abstract

2. YI 1.2 Ideal Cardiovascular Health Score Declines from Adolescence to Emerging Adulthood

Chloe Park, Siana Jones, Suzanne Williams, Alicja Rapala, Hannah Taylor, Laura Howe, Abigail Fraser, Nish Chaturvedi, Alun Hughes
Pages: S2 - S2
Purpose: To define and compare cardiovascular (CV) health scores (CHS) from adolescence (17 yrs) to emerging adulthood (24 yrs) using longitudinal data from a large British birth cohort. Methods: 3142 participants from the Avon Longitudinal Study of Parents and Children (ALSPAC) study attended clinical...
Conference Abstract

3. YI 1.3 Retinal Microvascular Calibers and Incident Depressive Symptoms: The Multi-Ethnic Study of Atherosclerosis

April C.E. van Gennip, Sanaz Sedeghat, Mercedes R. Carnethon, Norrina B. Allen, Barbara E.K. Klein, Mary Frances Cotch, Diana A. Chirinos, Coen D.A. Stehouwer, Thomas T. van Sloten
Pages: S3 - S3
Background: Cerebral microvascular dysfunction may contribute to depression via disruption of brain structures involved in mood regulation, but evidence is scarce. The retina allows for direct visualisation of a microvascular bed that shares anatomical and physiological similarities with the cerebral...
Conference Abstract

4. YI 1.4 Increases in Circulating Trimethylamine-N-Oxide Contribute to the Development of Age-Related Aortic Stiffness in Humans and Mice

Abigail G Casso, Rachel A Gioscia-Ryan, Zachary J Sapinsley, Nicholas S VanDongen, Amy E Bazzoni, Andrew P Neilson, Melanie C Zigler, Kevin P Davy, Douglas R Seals, Vienna E Brunt
Pages: S4 - S4
Age-related increases in aortic stiffness, assessed by pulse wave velocity (PWV), predict cardiovascular (CV)-related mortality, but the upstream drivers are incompletely understood. Purpose: To determine if higher circulating levels of the gut microbiome-derived metabolite trimethylamine-N-oxide (TMAO)...
Conference Abstract

5. YI 1.5 Ten Years of Ageing in the Middle-Aged Does not Increase Input Impedance or Wave Reflection–Insights from the Asklepios Study

Daimé Campos Arias, Marc L. De Buyzere, Julio A. Chirinos, Ernst R. Rietzschel, Patrick Segers
Pages: S5 - S6
Background: The changes experienced by the arterial system due to ageing are still incompletely understood. The aim of this study is to analyze the 10-year longitudinal evolution of input impedance parameters and wave reflection indices in a middle-aged population, and how these effective changes compare...
Conference Abstract

6. YI 1.6 Flow Mediated Slowing of Pulse Wave Velocity as a Measure of Endothelial Function

Anju Sharma, Dinu S. Chandran, Ashok Jaryal, Kishore K. Deepak
Pages: S7 - S7
Purpose: Ultrasonographic measurement of flow mediated dilatation (FMD) of brachial artery is the gold standard non-invasive technique to measure endothelial function. However, measurement of FMD is technically cumbersome, operator dependent and requires trained manpower, all of which limits its clinical...
Conference Abstract

7. YI 1.7 Transmural Quantification of Murine Vascular Smooth Muscle Cell Density Distribution from 3D Microscopy Images

Koen W.F. van der Laan, Koen D. Reesink, Myrthe M. van der Bruggen, Armand M.G. Jaminon, Remco T.A. Megens, Leon J. Schurgers, Tammo Delhaas, Bart Spronck
Pages: S8 - S9
Purpose: Investigating the biomechanical role of smooth muscle cells (SMCs) in arteries requires knowledge of their structural distributions. Compared to histology, 3D microscopy offers non-destructive ex vivo imaging under realistic conditions [1]. Robust 3D segmentation of SMCs, however, is challenging....
Conference Abstract

8. YI 1.8 A Computational Model-Based Study on the Effect of Abdominal Aortic Aneurysm on Pulse Wave Morphology

Tianqi Wang, Jordi Alastruey, Fuyou Liang
Pages: S10 - S11
Background: Abdominal aortic aneurysm (AAA) is usually asymptomatic and has an extremely high mortality if rupture occurs. Therefore, early detection and intervention are important. However, AAA is most often detected as an accidental finding during clinical imaging for other purposes [1]. Considering...
Conference Abstract

9. YI 2.1 Pulse Wave Velocity Estimation from the Radial PulseWaveform using Gaussian Process Regression: A Machine Learning Based Study

Weiwei Jin, Phil Chowienczyk, Jordi Alastruey
Pages: S12 - S12
Objective and Motivation: Pulse wave velocity (PWV) is known to be associated with vascular ageing, a risk factor for cardiovascular disease (CVD) [1]. The European gold standard measurement of PWV requires an experienced operator to measure pulse waveforms at multiple sites, sometimes together with...
Conference Abstract

10. YI 2.2 Spontaneous Cardiovascular Ageing of C57bl6 Mice Results in the Development of Aortic Stiffness Prior to Periphral Blood Pressure Alterations

Sofie De Moudt, Jhana O. Hendrickx, Dorien G. De Munck, Arthur J. Leloup, Wim Martinet, Guido R.Y. De Meyer, Paul Fransen
Pages: S13 - S14
Background: Although generally assumed to be an adaptive response to increased blood pressure (BP), arterial stiffness is now recognized as an independent predictor of cardiovascular (CV) events [1]. Moreover it precedes hypertension in at least two mouse models [2,3]. Therefore, the present study aims...
Conference Abstract

11. YI 2.3 Methylglyoxal, 3-Deoxyglucosone, and Glyoxal – Precursors of Advanced Glycation Endproducts – are not Independently Associated with Indices of Carotid Stiffness: The Maastricht Study

Myrthe van der Bruggen, Marleen M.J. van Greevenbroek, Koen D. Reesink, Coen D.A. Stehouwer, Tammo Delhaas, Bart Spronck, Casper G. Schalkwijk
Pages: S15 - S16
Background: Arterial stiffness is a strong predictor of cardiovascular diseases and all-cause mortality [1]. Increased fasting plasma concentrations of highly reactive dicarbonyl compounds – methylglyoxal (MGO), 3-deoxyglucosone (3-DG), and/or glyoxal (GO) – may cause arterial stiffening via for mation...
Conference Abstract

12. YI 2.4 Neural Baroreflex Sensitivity and Long-Term Effect of Antihypertensive Agents—A Pharmacological Substudy of the Paris Prospective Study III

Nicolas Danchin, Catherine Guibout, Xavier Jouven, Marie-Cécile Perier, Frederique Thomas, Catherine Fortier, Jean-Philippe Empana, Hakim Khettab, Rosa-Maria Bruno, Pierre Boutouyrie
Pages: S17 - S17
Background/Objectives: The baroreflex is a crucial mechanism acutely modulating vascular tone and heart rate response to maintain blood pressure (BP) in an optimal range. A decrease in baroreflex sensitivity (BRS) is associated with ageing, and pathological conditions such as hypertension and diabetes....
Conference Abstract

13. YI 2.5 Direct Measurement of Stiffness Index β of Superficial Arteries Without Blood Pressure Estimation

Rahul Manoj, P.M. Nabeel, Kiran V. Raj, Jayaraj Joseph, Mohanasankar Sivaprakasam
Pages: S18 - S18
Background: Arterial stiffness index (β) is a clinically accepted vascular metric, calculated from arterial pressure and diameter obtained simultaneously from a single arterial site [1]. Hence, accurate measurement of β can only be performed on arteries where pressure can be recorded along with the diameter....
Conference Abstract

14. YI 2.6 Comparison of Cardiovascular Disease Primary Prevention Guidelines between Australia, England and the United States

Niamh Chapman, Monique Breslin, Sarah Lay-Flurrie, Zhen Zhou, James Sharman, Mark Nelson, Richard McManus
Pages: S19 - S19
Objective: Cardiovascular disease (CVD) primary prevention guidelines recommend absolute CVD risk estimation to guide blood pressure and lipid therapy recommendations but are inconsistent despite relying on similar evidence. This study aimed to compare the populations recommended for treatment according...
Conference Abstract

15. P.01 Where Does the Reflected Wave Observed in the Ascending Aorta Come from?

Shima Abdullateef, Ashraf W. Khir
Pages: S20 - S21
Background: Wave reflections play a major role in changing the shape of the pressure waveform. Reflections measured at the aortic root (AR) are thought to be due to the tapering of the aorta [1] and multiple reflection sites, however, there is no consensus on the source of those reflected waves. This...
Conference Abstract

16. P.02 Differential ‘Mediators’ of Low-Flow ‘Mediated’ Constriction in Healthy vs Patients of Ischemic Heart Disease

Smriti Badhwar, Dinu Chandran, Ashok Jaryal, Rajiv Narang, Chetan Patel, Kishore Kumar Deepak
Pages: S22 - S22
Background: Low-flow mediated constriction (LFMC) has emerged as a non-invasive tool for assessment of endothelial dysfunction [1]. There is insufficient data on association between change in artery diameter during occlusion with its possible stimulus; ‘low flow’ state. This study aims to evaluate the...
Conference Abstract

17. P.03 Local Pulse Wave Velocity Estimation using a Double Gaussian Propagation Model

Fabian Beutel, Chris Van Hoof, Evelien Hermeling
Pages: S23 - S23
Background: Pulse wave velocity (PWV) is an established marker of arterial stiffness [1]. Local PWV estimates, however, are affected by confluence of incident and reflected waves, biasing the spatiotemporal propagation of the systolic foot (SF) in the distension waveform [2,3]. We, therefore, propose...
Conference Abstract

18. P.04 A Transfer-Function-Free Technique for the Non-Invasive Estimation of Central Arterial Pressure

Alessandro Giudici, Ioana Cretu, Madalina Negoita, Ian B Wilkinson, Ashraf W Khir
Pages: S24 - S24
Background: Central aortic pressure (CAP) is important for the determination of the cardiovascular risk. Transfer function (TF)-based techniques allow for estimating CAP non-invasively from pressure waveforms acquired distally in the circulation. However, TF-based CAP might preserve the high frequencies...
Conference Abstract

19. P.05 Development and Validation of a Novel Centroid Method for Estimating Effective Reflection Time

Avinash Kondiboyina, Joseph J Smolich, Michael MH Cheung, Jonathan P Mynard
Pages: S25 - S25
Background: The time at which reflected waves arrive at central arteries has an important influence on ventricular afterload. Current methods of estimating reflection time (RT), including zero-crossover [1], inflection-point [2], and foot methods [3], use only a single point on the pressure waveforms,...
Conference Abstract

20. P.06 Comparison of Manual vs. Automated Haemodynamic Monitoring Systems in the Cardiac Catheterization Laboratory

AbdulRehman Alanezi, Fayaz Mohammad Khan, Taher Alotaibi, Bandar Alhaddadi, Fahad Alanazi, Mohammad Alqahtani, Jaber Alsheri, Ali Masrahi, Faisal Aljumah, Hanan AlShamamry, Ziyad Alwasel, Mohammad Balghith, Kamal Ayoub, Ali Al Ghamdi, Azra Mahmud
Pages: S26 - S26
Background: Hemodynamic monitoring is an integral part of a cardiac catheterization procedure; however it is prone to many distortions, including damping and resonance [1]. Objectives: We sought to compare damping ratio, ascending aortic pressure waveform and invasive blood pressure between Manifold...
Conference Abstract

21. P.07 The Progression of Left Ventricular Ejection Time in Simulated Microgravity

Stefan Orter, Stefan Möstl, Martin Bachler, Fabian Hoffmann, Christopher C. Mayer, Eugenijus Kaniusas, Michaela Reisinger, Siegfried Wassertheurer, Jens Tank, Bernhard Hametner
Pages: S27 - S27
Introduction: Microgravity in space is known to cause major alterations in the cardiovascular system. Left ventricular ejection time (LVET) can be measured by the time from the onset point of the pressure wave to the incisura of the dicrotic notch. The aim of this study was to simulate microgravity by...
Conference Abstract

22. P.08 Biomechanical Characterization of Ascending Thoracic Aortic Aneurysms in Humans: A Continuum Approach to in vivo Deformations

Shaiv Parikh, Bart Spronck, Gijs Debeij, Berta Ganizada, Mitch Ramaekers, Simon Schalla, Ehsan Natour, Jos Maessen, Tammo Delhaas, Wouter Huberts, Elham Bidar, Koen Reesink
Pages: S28 - S29
Background: Dysfunctional cellular mechanosensing appears central to aneurysm formation [1]. We aimed to derive material parameters of aneurysm tissue from in vivo deformations, which may increase insight into the underlying structural integrity of the pathological tissue. Methods: Videos of tracking...
Conference Abstract

23. P.09 Differential Low Flow Mediated Constriction (LFMC) Responses in Radial and Brachial Arteries of Healthy Humans are Attributed to Occlusion Induced Flow Changes

Sakshi Sen, Dinu Chandran, Ashok Jaryal, Kishore Kumar Deepak
Pages: S30 - S30
Background: Literature describes differences in Low flow mediated constriction (LFMC) of radial versus brachial artery [1,2]. We investigated whether differences in occlusion induced changes in luminal flow and shear rates could explain the observed radial vs brachial differences in LFMC responses. Methods:...
Conference Abstract

24. P.10 Distal Arterial Occlusion at Different Grades of Supra-Systolic Pressures Differentially Modulates Flow Velocity and Shear Rates in Radial Artery

Anchal Singh, Smriti Badhwar, Dinu Chandran, Ashok Jaryal, Kishore Kumar Deepak
Pages: S31 - S31
Background: Low-flow-Mediated Constriction (LFMC) is considered as a measure of resting endothelial function and is believed to occur in response to reduction in flow during supra-systolic occlusion [1]. However, supra-systolic occlusion may alter flow profile with differential effects on anterograde...
Conference Abstract

25. P.12 Investigating the Role of Glycemic Markers in Pulse Pressure Amplification in Young Adults: The African-PREDICT Study

Yolandi Breet, Leandi Lammertyn, Wayne Smith
Pages: S32 - S33
Objective: Pulse pressure amplification (PPA) is described as the amplification of pulse pressure from central arteries to the periphery [1] and individuals with a decreased PPA have an increased risk of cardiovascular disease [2]. Adverse changes in PPA are evident in diabetic populations [3]; however,...
Conference Abstract

26. P.13 Pulse Wave Velocity Trajectories during Covid-19 Epidemic: Effect of Lockdown on Cardiovascular Health

Rosa Maria Bruno, Jean-Louis Pepin, Rui-Yi Yang, Vincent Vercamer, Paul Jouhaud, Pierre Escorrou, Pierre Boutouyrie
Pages: S34 - S34
Aim: To investigate PWV trajectories before and during the lockdown period among Withings Body Cardio bathroom scale users in France, in which a strict total lockdown was imposed, and Germany, in which partial social distancing measures were adopted. Methods: The study population is constituted by Withings...
Conference Abstract

27. P.14 Transcranial Colour Duplex Reveals Haemodynamically Significant Venous Flow Alterations Following Resection of Arteriovenous Malformation of the Brain

Kathryn Busch, Andrew Davidson, Mark Butlin, Alberto Avolio, Hosen Kiat
Pages: S35 - S35
Background: Resection of a brain arteriovenous malformation (bAVM) can impose several post-operative challenges including post- operative haemorrhage (POH) [1]. The mechanism of such complications remains controversial although deliberately inducing hypotension has proven successful for POH prevention...
Conference Abstract

28. P.15 Isolated Systolic Hypertension and Central Blood Pressure: Implications from the National Nutrition and Health Survey in Taiwan

Shao-Yuan Chuang, Hsing-Yi Chang, Hao-Min Cheng, Wen-Harn Pan, Chen-Huan Chen
Pages: S36 - S36
Objectives: We aimed to investigate the association between isolated systolic hypertension (ISH) and central blood pressure (BP) in a nationally representative population. Methods: A total of 2029 adults without anti-hypertensive medicine, aged ≥19 years old participated in the 2013–2016 National Nutrition...
Conference Abstract

29. P.16 Expanding on the Observed Correlation between the Ambulatory Arterial Stiffness Index and the Lower Limit of Cerebral Autoregulation during Cardiac Surgery

Benjamin Gavish, Allan Gottschalk, Charles W Hogue, Jochen Steppan
Pages: S37 - S37
Background: The lower limit of cerebral autoregulation (LLA) refers to the mean blood pressure (BP) below which cerebral blood flow becomes pressure-dependent, resulting, among others, in an increased stroke risk. The LLA measured during cardiac surgery, correlates with the vascular measure Ambulatory...
Conference Abstract

30. P.17 Reduced Isometric Contractility and Isobaric Compliance of the ex vivo Thoracic Aorta of Hypertensive APP23+/− overexpressing Mice due to Serum Corticosterone Levels

Jhana O. Hendrickx, Sofie De Moudt, Debby Van Dam, Guido R.Y. De Meyer, Paul Fransen
Pages: S38 - S39
Objective: Alzheimer’s disease (AD) is characterized by noticeable neuropsychiatric symptoms and cognitive decline [1]. In addition, cardiovascular disease (CVD) is a known etiological hallmark of AD pathogenesis [2]. Recent epidemiological evidence suggests an interplay between arterial stiffness (AS)...
Conference Abstract

31. P.18 Carotid Stiffness Parameters and Cerebral Blood Flow Pulsatility in Young Healthy Individuals across Races

Jie Liu, Michelle E. Favre, Stephanie G. Iring, Allan Knox, Jorge M. Serrador
Pages: S40 - S40
Background: Higher cerebral blood flow (CBF) pulsatility was found to be associated with severer brain white matter lesions in the elderly [1]. It was hypothesized that the central/elastic arterial stiffness/compliance may directly affect CBF pulsatility. However, it is still unclear which carotid stiffness...
Conference Abstract

32. P.19 Intradialytic Changes in Cerebral Blood Flow and Regional Changes in Arterial Stiffness

Mathilde Paré, Hasan Obeid, Lawrence Labrecque, Audrey Drapeau, Karine Marquis, Patrice Brassard, Mohsen Agharazii
Pages: S41 - S41
Purpose/Background/Objective: Cognitive decline is highly prevalent amongst end-stage renal disease (ESRD) patients and is accelerated upon initiation of hemodialysis (HD) [1]. ESRD increases aortic stiffness and blood flow pulsatility, which may damage small vessels of target organs like the brain [2]....
Conference Abstract

33. P.20 Evolving Structure-Function Correlates during Aortic Maturation and Aging

Cristina Cavinato, Jay D Humphrey
Pages: S42 - S42
Introduction: Unraveling aortic cellular and extracellular microstructural and mechanical mechanisms triggered to maintain homeostasis in murine aortae during maturation and aging is fundamental to better understand remodeling in human arteriopathies [1]. Methods: This study, combining ex-vivo extension-inflation...
Conference Abstract

34. P.21 Albuminuria intensifies the relationship between urinary sodium excretion and central pulse pressure: the Wakuya study

Kaname Tagawa, Yusuke Tsuru, Katsumi Yokoi, Takanori Aonuma, Junichiro Hashimoto
Pages: S43 - S43
Objectives: Central pulse pressure (cPP) is responsible for vital organ hemodynamics, [1,2] and its monitoring is important for cardiovascular disease prevention. [3] Excess sodium intake and (micro)albuminuria, a manifestation of renal microvascular damage, are also known as strong predictors of cardiovascular...
Conference Abstract

35. P.22 Mortality in 98 Type 1 Diabetes Mellitus (T1DM) and Type 2 Diabetes Mellitus (T2DM) Individuals Presenting to a Specialist Podiatry Clinic: Foot Ulcer Location is an Independent Risk Determinant

Heather Schofield, Samantha Haycocks, Adam Robinson, Simon G Anderson, Adrian Heald
Pages: S44 - S44
Purpose/Background: We previously demonstrated in both longitudinal study and meta-analysis (pooled relative-risk RR, 2.45)[1,2] that all-cause and cardiovascular mortality is significantly higher in people with diabetes foot ulceration (DFU) than with those without a foot ulcer. In this prospective...
Conference Abstract

36. P.23 Relationship Between Aortic Stiffness, Aortic, and Carotid Impedance with Vascular Aging in Community-Based Healthy People

Chao-Feng Liao, Shao-Yuan Chuang, Hao-Min Cheng, Chen-Huan Chen
Pages: S45 - S46
Background: Stiffening of the aorta has been associated with microvascular structural brain damage and cognitive dysfunction in cross-sectional and longitudinal studies, probably due to the reduced wave reflection at the interface between carotid and aorta and transmission of excessive flow pulsatility...
Conference Abstract

37. P.24 Factors Associated with Premature Vascular Aging in Patients with Arterial Hypertension

I.V. Inna Melekhina, E.G. Elizaveta Georgievna Medvedeva, S.V. Svetlana Ivanova, E.N. Elena Yushchuk, E.Yu. Ekaterina Trush
Pages: S47 - S47
Objectives: Identification of factors associated with premature vascular aging in patients with arterial hypertension (AH). Methods: The study included 61 patients (29 men, 32 women) with 1–2 grade AH without cardiovascular complications, aged 40 to 60 years, of which 28 (45.9%) had type 2 diabetes....
Conference Abstract

38. P.25 Radial-Digital Pulse Wave Velocity: A Non-Invasive Method for Assessing Stiffness of Peripheral Small Arteries

Hasan Obeid, Charles-Antoine Garneau, Catherine Fortier, Mathilde Pare, Pierre Boutouyrie, Mohsen Agharazii
Pages: S48 - S48
Pulse wave velocity (PWV) has been used to evaluate arterial stiffness of large arteries. Here, we examine the feasibility of radial-digital PWV (RD-PWV) as a measure of stiffness of smaller arteries, and its response to changes in local mean arterial pressure. In 29 healthy subjects, we used Complior...
Conference Abstract

39. P.26 Liver Transglutaminase 2 Level Comparison Among Different Dietary Interventions

Elif Oztemiz, Soner Dogan, Bilge Guvenc Tuna
Pages: S49 - S49
Purpose/Background/Objectives: Tissue transglutaminase (TG2) is a highly expressed protein especially in endothelial cells. TG2 has several functions including transamidation activity which is important in several processes such as extracellular matrix remodeling [1]. TG2 activity takes place in aortic...
Conference Abstract

40. P.27 Mechanisms of NADPH Oxidase Participation in the Regulation of Diaphragm Artery Contractile Responses

Anna Borzykh, Ilya Kuzmin, Olga Vinogradova, Olga Tarasova
Pages: S50 - S50
Reactive oxygen species (ROS) produced by NADPH-oxidase (NOX) participate in vascular tone control, but their effects in the arteries of respiratory muscles is poorly understood. Possible targets of vasoregulatory ROS influence are NO-pathway in the endothelium and Rho-kinase pathway in smooth muscle...
Conference Abstract

41. P.28 Comparison of Regional vs Local Arterial Parameters Using New us Technology

Pedro Forcada, NG Kendy, Ricardo Garcia, Romina Maur, Jose Florio, Horacio Almada
Pages: S51 - S51
Environment: It has been described that muscular arteries behaviour is different from aorta, and regional parameters like IMT, atherosclerotic plaques burden, PWV-c and endothelial function are related with age and risk factors and are powerful prognostic markers but it is not the case of local parameters...
Conference Abstract

42. P.29 Involvement of Cannabinoid Receptors in Regulation of MMPs, Cell Proliferation and Apoptosis in Vascular Smooth Muscle Cells

Bettina Greiner, Manuela Sommerfeld, Ulrich Kintscher, Kai Kappert, Elena Kaschina
Pages: S52 - S52
Objectives: Cannabinoid receptors CB1R and CB2R are expressed in the vascular smooth muscle cells (VSMCs) and may contribute to vascular remodeling process (O’Sullivan, 2015). This study aimed to investigate the implication of CB1R and CB2R in the regulation of matrix metalloproteases MMP2 and MMP9,...
Conference Abstract

43. P.30 Angiotensin II Infusion Leads to Aortic Dissection in LRP8 Deficient Mice

Jeremy Lagrange, Stefanie Finger, Sabine Kossmann, Venkata Garlapati, Wolfram Ruf, Philip Wenzel
Pages: S53 - S53
Background/Objectives: Myeloid cells are crucial for the development of vascular inflammation. Low-density lipoprotein receptor-related protein 8 (LRP8) or Apolipoprotein E receptor 2 (ApoER2), is expressed by macrophages, endothelial cells and platelets and has been implicated in the development of...
Conference Abstract

44. P.31 Von Willebrand Factor Induces Vascular Smooth Muscle Cell Proliferation and Migration Through Low Density Lipoprotein-Related Receptor Protein 4 and αvβ3 Integrin

Cécile V. Denis, Patrick Lacolley, Jeremy Lagrange, Peter J. Lenting, Jean-Baptiste Michel, Alexandre Raoul, Veronique Regnault
Pages: S54 - S54
Background and Objectives: Von Willebrand factor (VWF) is a plasma glycoprotein involved in primary hemostasis but recent data suggest additional roles beyond hemostasis in angiogenesis and potentially in vascular smooth muscle cell (VSMC) proliferation. Our aim was to investigate how VWF can modulate...
Conference Abstract

45. P.32 Non-Invasive Measures of Arteriosclerosis Across Childhood and Adolescence: Insights Into the Natural History of Disease

Reeja Nasir, Tommy Ye Cai, Alice Meroni, Michael Skilton
Pages: S55 - S55
Objectives: Non-invasive methodologies for assessing arteriosclerosis, including carotid intimal-medial thickness (cIMT) for assessing subclinical atherosclerosis and carotid-femoral pulse wave velocity (cfPWV) for measuring arterial stiffness, are well established and validated in adults [1, 2]. However,...
Conference Abstract

46. P.33 Changes in Blood Pressure, Pulse Wave Velocity and Augmentation Index Induced by Postural Changes and Exercise

Enrique Rodilla, José Chordá, Andrea Gea, Jose Antonio Costa
Pages: S56 - S56
Objectives: To determine how orthostatic changes in body position alter BP and estimation of pulse wave velocity (PWV) and Augmentation Index (AIx), when changing from supine to the sitting position [1]. Also, to analyze the effect of a short physical exercise and of physical training status on PWV/AIx...
Conference Abstract

47. P.34 Preeclampsia Leads to the Delayed Development of Sympathetic Control of the Cardiovascular System in the Offspring

Ekaterina Selivanova, Anastasia Shvetsova, Victoria Potekhina, Dina Gaynullina, Anna Borzykh, Oxana Kiryukhina, Vladislav Kuzmin, Olga Tarasova
Pages: S57 - S57
Background: Preeclampsia is a common pregnancy disease characterized by hypertension and kidney failure. Recent studies have shown that even in the case of successful delivery, preeclampsia could induce long-term effects in the offspring. Nevertheless, the effects of preeclampsia on the cardiovascular...
Conference Abstract

48. P.35 TASK-1 Channels Play an Anticontractile Role in Rat Septal Coronary Artery Under Pharmacological Blockade of Endothelium

B.S. Varvara Lazarenko, Anastasia Shvetsova, Dina Gaynullina, Rudolph Schubert
Pages: S58 - S58
Purpose/Background/Objectives: TASK-1 (TWIK-related acid-sensitive potassium) channels conduct background K+ currents in smooth muscle cells of pulmonary arteries suppressing vasocontraction. However, the vasomotor role of TASK-1 channels in systemic arteries as well as their regulation by the endothelium...
Conference Abstract

49. P.37 An Assessment of Potential Sources of Error that May Arise in the Measurement of Carotid-Femoral Pulse Wave Velocity

James Cox, Isabella Tan, Alberto Avolio, Mark Butlin
Pages: S59 - S59
Objectives: Carotid-femoral pulse wave velocity (cfPWV) approximates aortic stiffness and is a predictor of cardiovascular events. Despite the literature highlighting the clinical relevance of cfPWV, there is minimal integration of this parameter in clinical assessments. An underlying reason may stem...
Conference Abstract

50. P.38 Comparison of Arterial Hemodynamics in Early Vascular Aging (EVA), Average Vascular Aging (AVA) and Healthy Vascular Aging (HVA)

Chen-hua Lin, Hao-Min Cheng, Yu-Ting Ko, Li-Ning Peng, Liang-Kung Chen, Chen-Huan Chen
Pages: S60 - S60
Background: Large artery stiffening, as indexed by carotid-femoral pulse wave velocity (cfPWV), may vary substantially among individuals. The present study aimed to characterize the arterial mechanical properties of the macro- and microvasculature in subjects with early or healthy vascular aging (EVA,...
Conference Abstract

51. P.39 The Role of Advanced Glycation End Products in Vascular Ageing. Which Parameter is the Most Suitable as Biomarker?

Otto Mayer, Július Gelžinský, Jitka Seidlerová, Jan Filipovský
Pages: S61 - S61
Background: Advanced glycation end products (AGEs) are involved into several pathophysiologic processes in vascular diseases, including progressive loss of elasticity of vessel wall (arterial stiffness). Circulating soluble receptor for AGEs (sRAGE) act as a decoy and counterbalanced the harmful properties...
Conference Abstract

52. P.40 Ambulatory Measurement of Carotid Stiffness with a Novel Accelerometric System

R. Arathy, P.M Nabeel, Joseph Jayaraj, V.V Abhidev, Sivaprakasam Mohanasankar
Pages: S62 - S62
Purpose: Arterial stiffness is a well-established marker for cardiovascular health assessment. Current methods rely on expensive imaging systems and specialised operators to perform local stiffness evaluation from the common carotid artery (CCA) and cannot be used for ambulatory monitoring in chronic...
Conference Abstract

53. P.41 Measurement of Pressure-dependent Intra-Beat Changes in Carotid Pulse Wave Velocity using Image-Free Fast Ultrasound

Kiran V Raj, P M Nabeel, Jayaraj Joseph, Dinu Chandran, Mohanasankar Sivaprakasam
Pages: S63 - S63
Background: The clinical significance of pressure-dependent intra-beat changes in local pulse-wave velocity (C) has recently come to light [1]. While reported methods require arterial pressure and diameter measurements from a single site to assess intra-beat changes in C, we present an image-free fast...
Conference Abstract

54. P.42 The Effects of Chemotherapy on Arterial Stiffness in Patients with Hodgkin Lymphoma

Constantinos Anagnostopoulos, Stavroula Giannouli, Nikolaos Ioakimidis, Paulos Kafouris, Iosif Koutagiar, Anastasia Sioni, Eirini Solomou, Dimitrios Terentes-Printzios, Dimitrios Tousoulis, Charalampos Vlachopoulos
Pages: S64 - S64
Introduction: Malignancies and cardiovascular disease are the two leading causes of mortality worldwide [1]. While there is extensive literature describing the cardiotoxic effects of chemotherapy on left ventricular systolic function [2,3], there is only little evidence regarding chemotherapy effects...
Conference Abstract

55. P.43 The Association Between Early Vascular Aging and Cyclothymic Affective Temperament

Milan Vecsey-Nagy, Bálint Szilveszter, Márton Kolossváry, Xénia Gonda, Zoltán Rihmer, Béla Merkely, Pál Maurovich-Horvat, János Nemcsik
Pages: S65 - S65
Objectives: Affective temperaments (depressive, anxious, irritable, hyperthymic, cyclothymic) are regarded as the biologically stable core of personality, and accumulating data implies their relationship with cardiovascular diseases. There are currently limited data on the association of affective temperaments...
Conference Abstract

56. P.44 Application of an Algorithm Developed for Measuring Gastrointestinal Motility to the Assessment of Arterial Mechanical Properties

Andrew Bard, Stephen Greenwald, Sandip Sarkar
Pages: S66 - S67
Background: GIQuant (Motilent, London) is an algorithm for analysing cine-MRI, using the displacement fields generated by registration of indivisdual ciné frames. It produces a summary of how much movement occurs (“motility”) for anatomical locations within a reference image [1]. Although it is used...
Conference Abstract

57. P.45 Characterization of the Microcirculatory Response to Gravity-Induced Changes using Thermal Imaging

Noam Moyal, Noa Darchi, Oshrit Hoffer, Neta Rabin, Benjamin Gavish, Moshe Halak, Zehava Ovadia-Blechman
Pages: S68 - S68
Objective: The goal of this study was to characterize the changes in the palm’s blood distribution in response to a decrease in blood pressure due to gravity-induced changes, using thermal imaging. Methods: Thermal hands images were taken from ten healthy volunteers, without any known vascular pathologies,...
Conference Abstract

58. P.46 Assessment of Intraplaque Hemorrhage by Photoacoustics Imaging (PAI): First in-vivo Human Validation Study

Rosa Maria Bruno, Yuki Imaizumi, Hasan Obeid, Michael Jaeger, Pierre Julia, Patrick Bruneval, David Calvet
Pages: S69 - S69
Aim: To validate a photoacoustic imaging (PAI) system, for the identification of intraplaque hemorrhage, comparing it with MRI and histology (gold standard). Methods: 25 patients with carotid stenosis >70% and clinical indication to tromboendoarterectomy were recruited. Angio-MRI for intraplaque...
Conference Abstract

59. P.47 Feasibility Evaluation of Imaging-Free Ultrasound Technology to Measure Diameters of Brachial and Radial Arteries for Assessment of Endothelial Function

Dinu Chandran, Jayaraj Joseph, Sakshi Sen, Kiran Raj, P.M. Nabeel, Kishore Kumar Deepak
Pages: S70 - S70
Background: Ultrasonographic imaging to record changes in peripheral arterial diameter associated with Flow mediated dilatation or Low flow mediated constriction is routinely used to assess various facets of vascular endothelial function. Imaging poses many challenges including requirement of costly...
Conference Abstract

60. P.48 Ultrasound-Based Velocity and Acceleration of the Carotid Atheromatous Plaque in Asymptomatic Patients with Moderate and Severe Stenosis

Kalliopi Dalakleidi, Spyretta Golemati, Aimilia Gastounioti, Christos Liapis, Konstantina Nikita
Pages: S71 - S71
Purpose: The purpose of this study was to investigate differences in ultrasound-based velocities and accelerations of the carotid atheromatous plaque between asymptomatic patients with moderate and severe stenosis, based on the assumption that plaque motion features are sensitive to cardiovascular health...
Conference Abstract

61. P.49 Aortic Root Longitudinal Strain by Speckle-Tracking Echocardiography: Comparison with Cardiac Magnetic Resonance and Predictive Value in Marfan Syndrome Patients

Andrea Guala, Maria Isabel Pons, Aroa Ruiz-Muñoz, Lydia Dux-Santoy, Laura Madrenas, Minerva Gandara, Filipa Valente, Angela Lopez-Sainz, Laura Galian, Laura Gutierrez, Augusto Sao-Aviles, Teresa Gonzalez-Alujas, Ignacio Ferreira, Arturo Evangelista, Jose Rodriguez-Palomares, Gisela Teixido-Tura
Pages: S72 - S72
Background: Low longitudinal strain of the ascending aorta (AAo) by cardiac magnetic resonance (CMR) predicts dilation and aortic events in Marfan syndrome (MFS) [1], possibly reflecting aortic stiffness [2]. Speckle-tracking is established for cardiac deformation, but proximal aorta applications are...
Conference Abstract

62. P.50 Radial Artery Phenotyping in Fibromuscular Dysplasia Through Ultra-High Frequency Ultrasound: A Radiomic Approach

Federica Poli, Rosa Maria Bruno, Francesco Faita, Hakim Khettab, Michel Azizi, Saverio Vitali, Mirco Cosottini, Davide Caramella, Lorenzo Ghiadoni, Stefano Taddei, Pierre Boutouyrie, Alexandre Persu, Xavier Jeunemaitre, Aurélien Lorthioir
Pages: S73 - S73
Rationale and Aim: This study is aimed at identifying possible patterns of vascular wall disarray and remodeling in radial arteries of patients with fibromuscular dysplasia (FMD), by means of ultrahigh frequency ultrasound (UHFUS). Methods: UHFUS scans of the radial arteries and of 30 FMD patients and...
Conference Abstract

63. P.53 Ascending Aorta Diameter and Pulse Wave Velocity are Increased and Local Hemodynamic is Disrupted in Patients with Blunt Traumatic Thoracic Aortic Injury Treated by TEVAR

Andrea Guala, Daniel Gil Sala, Aroa Ruiz-Muñoz, Marvin Garcia-Reyes, Lydia Dux-Santoy, Gisela Teixido-Tura, Cristina Tello, Filipa Valente, Angela Lopez-Sainz, Laura Galian, Laura Gutierrez, Kevin Johnson, Oliver Wieben, Ignacio Ferreira, Arturo Evangelista, Sergi Bellmunt-Montoya, Jose Rodriguez-Palomares
Pages: S74 - S75
Background: Thoracic endovascular aortic repair (TEVAR) is becoming the preferred treatment option to repair the proximal descending aorta after rupture following blunt traumatic injury. However, hemodynamic and mechanic implications of this intervention are poorly understood. Exploiting the possibilities...
Conference Abstract

64. P.54 Biomarkers and Haemodynamic Predictors of Left Atrial Strain in Early Hypertension

Maryam Bukhamseen, Nada Al-Saileek, Ahmed Al-Saileek, Mohammad Ghormalla Ghamdi, Tahlil Wasame, Ahmed Omran, Azra Mahmud
Pages: S76 - S76
Background: In the early stages of atrial remodeling, increased aortic stiffness might indicate atrial fibrosis. Objective: This study aimed to investigate the association between left atrial (LA) mechanical function, assessed by two-dimensional speckle tracking echocardiography and aortic stiffness...
Conference Abstract

65. P.55 Dietary Nitrate Prevents Progression of Carotid Subclinical Atherosclerosis Through BP-Independent Mechanisms in Patients with or at Risk of Type 2 Diabetes Mellitus: Results from the Double-Blind, Randomized-Controlled, Factorial Vasera Trial

Franca Morselli, Luca Faconti, Charlotte E Mills, Steve Morant, Philip J Chowienczyk, J Kennedy Cruickshank, Andrew J Webb, Alessandro Cavarape
Pages: S77 - S77
Background: Epidemiological and animal studies suggest the potential of dietary nitrate (NO 3−) to inhibit atherogenesis. Spironolactone may improve arterial stiffness. We tested if 6 months’ intervention with dietary nitrate and spironolactone could affect carotid subclinical atherosclerosis and stiffness...
Conference Abstract

66. P.56 Differences in Vascular Effects Between One Session of Moderate-Intensity Continuous Physical Exercise and High-Intensity Interval Physical Exercise in Individuals with High Blood Pressure

Sara Rodrigues, Renata G S Verardino, Marcel J A Costa, Ana Luíse Duenhas-Berger, Valéria Costa-Hong, Luiz A Bortolotto
Pages: S78 - S78
Purpose: To compare augmentation index (AIx) between one Moderate-intensity continuous physical exercise (MICPE) and one High-intensity interval physical exercise (HIIPE) session in normal/high normal blood pressure (BP) (120–140 for systolic and 80–90 mmHg for diastolic). Additionally, to compare two...
Conference Abstract

67. P.57 Acetylsalicylic Acid Reduces Passive Aortic Wall Stiffness and Cardiac Remodelling in a Mouse Model of Advanced Atherosclerosis

Lynn Roth, Wim Martinet, Guido R.Y. De Meyer
Pages: S79 - S80
Background: Acetylsalicylic acid (ASA) is used in secondary prevention of cardiovascular disease (CVD) because of its antithrombotic effects. We investigated whether ASA has additional therapeutic value by preventing the progression of inflammation and cardiovascular remodelling in mice with stable atherosclerosis...
Conference Abstract

68. P.58 Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice

Bart Spronck, Marcos Latorre, Sameet Mehta, Alexander W. Caulk, Abhay B. Ramachandra, Sae-Il Murtada, Alexia Rojas, Chang-Sun He, Bo Jiang, Mo Wang, Matthew R. Bersi, George Tellides, Jay D. Humphrey
Pages: S81 - S82
Background: Many genetic mutations affect aortic structure and function in mice, but little is known about the influence of background strain. We compared the biomechanical, structural, and gene expression responses of C57BL/6J and 129SvEv aortas to angiotensin II (AngII)-induced hypertension. Methods:...
Conference Abstract

69. P.60 Improvement in Muscular Strength Within One Year is Associated with Increased Arterial Stiffness in Young Male Soccer Players

MPH Lisa Baumgartner, Heidi Weberruß, Katharina Appel, Tobias Engl, Renate Oberhoffer-Fritz, Thorsten Schulz
Pages: S83 - S83
Purpose: The adaptation process of the cardiovascular system to exercise and muscular strength in young athletes is unclear. Therefore, we investigated the influence of changes in muscular strength and weekly training load within one year on arterial stiffness in young male soccer players. Methods:...
Conference Abstract

70. P.61 Impact of Kidney Transplantation on Arterial Reservoir-Wave Analysis

Nadège Côté, Emy Philibert, Mathilde Paré, Rémi Goupil, Catherine Fortier, Martin G. Schultz, James E. Sharman, Mohsen Agharazii
Pages: S84 - S84
Purpose/Background/Objective: According to reservoir-wave approach (RWA) arterial pressure is the sum of a reservoir pressure (RP) accounting for dynamic storage and release of blood from arteries, and an excess pressure (XSP) analogous to flow. RP is the minimal left ventricular work required to generate...
Conference Abstract

71. P.62 Assessment of Isoflavone and Ethanolic Extract of Inonotus Obliquus on Experimentally Induced Diabetes

Kingsley Duru, Cara Hildreth, Alberto P. Avolio, Jacqueline K. Phillips, Mark Butlin
Pages: S85 - S85
Purpose: Studies support beneficial effects of isoflavones, but antidiabetic effects of these agents remains unconfirmed [1,2]. This pilot study investigates isoflavones and Inonotus obliquus (chaga) extract effects on diabetes. Methods: Diabetes was induced (streptozotocin 65 mg/kg, nicotinamide 110...
Conference Abstract

72. P.63 Sarcopenia and Atherosclerotic Occlusive Disease: How Much We Know and What We Need to Know About this Association?

Joana Ferreira, Alexandre Carneiro, Pedro Cunha, Armando Mansilha, Isabel Vila, Cristina Cunha, Cristina Silva, Adhemar Longatto-Filho, Maria Correia-Neves, Gustavo Soutinho, Luís Meira-Machado, Amilcar Mesquita, Jorge Cotter
Pages: S86 - S87
Purpose/Background: Sarcopenia (decrease of muscle mass and function) has been linked with atherosclerosis [1]. The EWGSOP2 updated consensus, uses low muscle strength as the primary indicator of sarcopenia [2]. It is acknowledged that strength is better than mass for predicting adverse outcomes [2]....
Conference Abstract

73. P.64 Active Vitamin D Treatment Does Not Improve Arterial Stiffness and Markers of Cardio-Renal Risk in Patients with Type 2 Diabetes and Stage 3 Chronic Kidney Disease: a Randomised Controlled Trial

Nikolaos Fountoulakis, Salma Ayis, Anastasios Mangelis, Angeliki Panagiotou, Maria Flaquer, Stanimir Stoilov, Giuseppe Maltese, GianCarlo Viberti, Stephen Thomas, Luigi Gnudi, Janaka Karalliedde
Pages: S88 - S88
Background and Aims: Active vitamin D [1,25(OH)2D3] deficiency is a potential modifiable risk factor for cardiovascular (CVD) and renal disease in patients with type 2 diabetes (T2DM) and stage 3/4 chronic kidney disease (CKD). Exact mechanisms are unclear. Arterial stiffness is an independent predictor...
Conference Abstract

74. P.65 Increased Biomarkers of Endothelial Dysfunction and Thrombotic Microenvironment in Patients with Autoimmune Rheumatic Disorders Free from Cardiovascular Comorbidities

Eleni Gavriilaki, Panagiota Anyfanti, Stella Douma, Eugenia Gkaliagkousi
Pages: S89 - S89
Purpose/Background/Objectives: Cardiovascular risk is increased in patients with autoimmune rheumatic disorders [1]. Endothelial and platelet MVs (EMVs, PMVs) are small vesicles (0.1–1 μm) released from plasma membrane and represent novel markers of endothelial dysfunction and thrombosis. Their levels...
Conference Abstract

75. P.66 Radial Artery Systolic-Diastolic Pulse Transit Time After Kidney Transplantation

Emy Philibert, Hasan Obeid, Mathilde Paré, Nadège Côté, Catherine Fortier, Rémi Goupil, Mohsen Agharazii
Pages: S90 - S90
Purpose/Background/Objective: We have previously shown that restoration of kidney function through kidney transplantation (KTx) is associated with improved aortic stiffness. In this study, we aim to examine whether this change in aortic stiffness translates into improvement of radial artery systolic-diastolic...
Conference Abstract

76. P.67 The Effects of Chemotherapy on Arterial Inflammation Assessed by 18FDG PET-CT in Patients with Lymphoma

Constantinos Anagnostopoulos, Stavroula Giannouli, Nikolaos Ioakimidis, Paulos Kafouris, Iosif Koutagiar, Anastasia Sioni, Eirini Solomou, Dimitrios Terentes-Printzios, Dimitrios Tousoulis, Charalampos Vlachopoulos
Pages: S91 - S91
Introduction: Anti-cancer treatment can lead to increased cardiovascular morbidity among lymphoma survivors [1]. This may be the result of direct effect of treatment on heart function, or indirect acceleration of atherosclerosis. 18F-fluorodeoxyglucose (FDG) uptake is a sensitive and robust marker for...
Conference Abstract

77. P.68 WaveGraft–A Novel Endovascular Device Concept for Restoring the Natural Arterial Cushioning Effect

Florian Stefanov, Dave Veerasingam, Sarah Sayed, Patrick Delassus, Jonathan Bouchier-Hayes, Liam Morris
Pages: S92 - S92
Background and Objectives: The cushioning effect of large, healthy arteries reduces pulsatile afterload to the heart, reduces pulsatility in the microvasculature of target organs, and promotes coronary/cerebral perfusion [1]. With age, large arteries become stiffer, which increases both pulse wave velocity...