Artery Research

Volume 26, Issue Supplement 1, December 2020, Pages S90 - S90

P.66 Radial Artery Systolic-Diastolic Pulse Transit Time After Kidney Transplantation

Authors
Emy Philibert1, 2, *, Hasan Obeid1, 2, 4, 5, Mathilde Paré1, 2, Nadège Côté1, 2, Catherine Fortier1, 2, 4, 5, Rémi Goupil3, Mohsen Agharazii1, 2
1CHU de Québec Research Center, L’Hôtel-Dieu de Québec Hospital
2Division of Nephrology, Faculty of Medicine, Université Laval
3Hôpital du Sacré-Cœur de Montréal
4INSERM U-970, Paris Cardiovascular research Center (PARCC)
5AP-HP, Pharmacology Unit, Hôpital Européen Georges Pompidou, Université de Paris
*Corresponding author. Email: emy.philibert.1@ulaval.ca
Corresponding Author
Emy Philibert
Available Online 31 December 2020.
DOI
10.2991/artres.k.201209.075How to use a DOI?
Keywords
Kidney-transplantation; pulse-transit-time; radial-artery
Abstract

Purpose/Background/Objective: We have previously shown that restoration of kidney function through kidney transplantation (KTx) is associated with improved aortic stiffness. In this study, we aim to examine whether this change in aortic stiffness translates into improvement of radial artery systolic-diastolic pulse transit time.

Methods: Before and three months after KTx, we obtained radial pressure waveforms using applanation tonometry, in a group of 61 patients with restored renal function (eGFR > 45 ml/min/1,73 m2). Radial waveforms were recorded over a 10 seconds period and ensemble-averaged (using in house-MATLAB program) to obtain a single waveform and then modelled using two Gaussian functions, was then determined as the transit time between the first systolic peak T1 and the early diastolic peak T2.

Results: 61 patients (66% male, mean age: 48 ± 14 years, mean eGFR 3 months after Ktx: 66.0 ± 17.1) were assessed. After KTx, there was a significant reduction in central systolic (125,266 ± 21,848 to 108,994 ± 14,407, p < 0.001) and diastolic BP (84,718 11,679 to 74,092 9,774, p < 0.001), carotid-femoral PWV (11,444 2,626 to 10,235 1,890, p < 0.001) and carotid-radial PWV (9,350 1,485 to 8,831 1,291, p = 0,003). While T1 declined (0.184 [0.173–0.198] to 0.180 [0.168–0.194], p = 0.018), there were no significant changes in T2 (0.322 [0.295–0.360] to 0.318 [0.283–0.355], p = 0.169) and in dT1-2 (0.135 [0.119–0.161] to 0.134 [0.117–0.167], p = 0.457).

Conclusions: Contrary to our expectation, three months after KTx, we did not observe a significant change in radial systolic-diastolic pulse transit time after kidney transplantation, despite an improvement of BP, aortic and brachial stiffness.

Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Volume-Issue
26 - Supplement 1
Pages
S90 - S90
Publication Date
2020/12/31
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.201209.075How to use a DOI?
Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Emy Philibert
AU  - Hasan Obeid
AU  - Mathilde Paré
AU  - Nadège Côté
AU  - Catherine Fortier
AU  - Rémi Goupil
AU  - Mohsen Agharazii
PY  - 2020
DA  - 2020/12/31
TI  - P.66 Radial Artery Systolic-Diastolic Pulse Transit Time After Kidney Transplantation
JO  - Artery Research
SP  - S90
EP  - S90
VL  - 26
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201209.075
DO  - 10.2991/artres.k.201209.075
ID  - Philibert2020
ER  -