P.03 Local Pulse Wave Velocity Estimation using a Double Gaussian Propagation Model
- 10.2991/artres.k.201209.017How to use a DOI?
- Local pulse wave velocity
Background: Pulse wave velocity (PWV) is an established marker of arterial stiffness . Local PWV estimates, however, are affected by confluence of incident and reflected waves, biasing the spatiotemporal propagation of the systolic foot (SF) in the distension waveform [2,3]. We, therefore, propose a Double Gaussian Propagation Model (DGPM) to estimate PWV in consideration of local wave dynamics.
Methods: Ten subjects (38 ± 10 years) were measured in rest for 2 minutes, repeatedly in 3 sessions over 3 weeks. From carotid ultrasonography (Vantage64, VerasonicsInc.,USA), we acquired 32 distension waveforms over a 19 mm wide arterial segment, simultaneously with noninvasive continuous blood pressure (NOVA, FinapresMedicalSystemsB.V., NL). The DGPM, fitted to the detrended second derivative (of the SF-complex, was defined as:
with time t[s], segment distance x[m] and 8 parameters modelling all 32 waveforms, i.e. a(mplitude)[a.u.], c(entroid)[s], w(idth)[s] and v(elocity)[m/s] of the forward (1) and backward (2) propagating wave, respectively (see Figure). Quality of fitting (QoF) was assessed as percentage of the waveform accounted by DGPM relative to the mean amplitude. Per cardiac cycle, PWVDGPM (= v1), spatiotemporal PWV(PWVST) from linear regression of SF distances and timings, and Bramwell-Hill PWV (PWVBH) were computed . Pearson correlation coefficients were computed between session means of local PWV measures and PWVBH.
Results: The DGPM adequately models the SF-complex (mean QoF = 85% for >20.000 cardiac cycles). For PWVBH, PWVDGPM shows a significantly higher predictive utility compared to PWVST (r: 0.64 vs. 0.10).
Conclusion: The proposed DGPM demonstrates significant predictive utility for PWV by accounting for wave confluence. This may facilitate the clinical practicality of local arterial stiffness estimation.
- © 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Fabian Beutel AU - Chris Van Hoof AU - Evelien Hermeling PY - 2020 DA - 2020/12/31 TI - P.03 Local Pulse Wave Velocity Estimation using a Double Gaussian Propagation Model JO - Artery Research SP - S23 EP - S23 VL - 26 IS - Supplement 1 SN - 1876-4401 UR - https://doi.org/10.2991/artres.k.201209.017 DO - 10.2991/artres.k.201209.017 ID - Beutel2020 ER -