Artery Research

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Volume 26, Issue Supplement 1, December 2020, Pages S3 - S3

YI 1.3 Retinal Microvascular Calibers and Incident Depressive Symptoms: The Multi-Ethnic Study of Atherosclerosis

Authors
April C.E. van Gennip1, *, Sanaz Sedeghat2, Mercedes R. Carnethon2, Norrina B. Allen2, Barbara E.K. Klein3, Mary Frances Cotch4, Diana A. Chirinos2, Coen D.A. Stehouwer1, Thomas T. van Sloten1
1Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre
2Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University
3Ocular Epidemiology, University of Wisconsin-Madison
4Division of Epidemiology and Clinical Applications, Intramural Research Program, National Eye Institute, National Institutes of Health
*Corresponding author. Email: april.van.gennip@mumc.nl
Corresponding Author
April C.E. van Gennip
Available Online 31 December 2020.
DOI
10.2991/artres.k.201209.003How to use a DOI?
Keywords
Depression; retina; microvasculature; epidemiology
Abstract

Background: Cerebral microvascular dysfunction may contribute to depression via disruption of brain structures involved in mood regulation, but evidence is scarce. The retina allows for direct visualisation of a microvascular bed that shares anatomical and physiological similarities with the cerebral microvasculature. We investigated the association between baseline central retinal arteriolar and venular calibers (CRAE and CRVE) and 7.8-year change of CRAE and CRVE and incident depressive symptoms.

Methods: Longitudinal data are from the Multi-Ethnic Study of Atherosclerosis (MESA) of 3,999 participants (62.3 ± 9.7 years; 48.2% women; 26.6% black) without depressive symptoms at baseline. Presence of depressive symptoms, defined as Centre for Epidemiological Studies Depression Scale score ≥16 and/or use of antidepressant medication, was determined in 2002–2004 (baseline, MESA exam 2) and at three follow-up examinations every 1.5–2 years thereafter. Fundus photography was performed at MESA exam 2 and exam 5 after a mean of 7.8 years.

Results: After a mean follow-up of 6.1 years, 21.7% (n = 869) had incident depressive symptoms. After adjustment for socio- demographic, lifestyle and cardiovascular factors, one SD larger baseline CRVE (21.8 µm) was associated with a higher risk of depressive symptoms (hazard ratio: 1.10; 95% confidence interval: 1.02–1.18), but one SD larger baseline CRAE (14.1 µm) was not (hazard ratio: 1.05; 0.98–1.13). Neither 7.8-year change of CRAE nor CRVE were associated with depressive symptoms (odds ratios: 1.06; 0.90–1.24, and 1.06; 0.91–1.23, respectively).

Conclusions: Larger baseline CRVE is associated with a higher incidence of depressive symptoms. This might support the hypothesis that cerebral microvascular dysfunction contributes to the development of depression.

Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
26 - Supplement 1
Pages
S3 - S3
Publication Date
2020/12/31
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.201209.003How to use a DOI?
Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - April C.E. van Gennip
AU  - Sanaz Sedeghat
AU  - Mercedes R. Carnethon
AU  - Norrina B. Allen
AU  - Barbara E.K. Klein
AU  - Mary Frances Cotch
AU  - Diana A. Chirinos
AU  - Coen D.A. Stehouwer
AU  - Thomas T. van Sloten
PY  - 2020
DA  - 2020/12/31
TI  - YI 1.3 Retinal Microvascular Calibers and Incident Depressive Symptoms: The Multi-Ethnic Study of Atherosclerosis
JO  - Artery Research
SP  - S3
EP  - S3
VL  - 26
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201209.003
DO  - 10.2991/artres.k.201209.003
ID  - vanGennip2020
ER  -