P.21 Albuminuria intensifies the relationship between urinary sodium excretion and central pulse pressure: the Wakuya study
- 10.2991/artres.k.201209.034How to use a DOI?
- Central hemodynamics; kidney; sodium
Objectives: Central pulse pressure (cPP) is responsible for vital organ hemodynamics, [1,2] and its monitoring is important for cardiovascular disease prevention.  Excess sodium intake and (micro)albuminuria, a manifestation of renal microvascular damage, are also known as strong predictors of cardiovascular disease. [4,5] We sought to investigate the cross-sectional relationships among dietary sodium consumption, albuminuria and cPP in the general population.
Methods: Subjects were 933 apparently healthy adults in Wakuya town, Miyagi, Japan (mean age, 56 ± 10 years). Radial pressure waveforms were recorded with applanation tonometry to estimate mean arterial pressure (MAP), cPP, forward and backward pressure amplitudes, and augmentation index. Urinary sodium/creatinine ratio (UNaCR) and albumin/creatinine ratio (UACR) were measured in spot urine samples.
Results: Median values of UNaCR, UACR and cPP were 139 (interquartile range, 89–205) mEq/g, 5 (4–11) mg/g and 38 (33–45) mmHg, respectively. Both UACR and UNaCR were positively correlated with cPP, even after adjusted for MAP (p < 0.001). Moreover, UACR and UNaCR had a synergistic influence on increasing cPP, which was independent of age, sex, estimated glomerular filtration rate, hyperlipidemia and diabetes (interaction p < 0.05). A similar synergistic influence between UACR and UNaCR was found on the forward but not backward pressure amplitude or augmentation index. The overall results were not altered on replacement of UACR with the existence of chronic kidney disease.
Conclusions: (Micro)albuminuria strengthens the positive association between urinary sodium excretion and central pulse (and systolic forward) pressure. Excess sodium intake may magnify cardiovascular risk through widening aortic pulsatile pressure, particularly in the presence of concomitant chronic kidney disease.
- © 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Kaname Tagawa AU - Yusuke Tsuru AU - Katsumi Yokoi AU - Takanori Aonuma AU - Junichiro Hashimoto PY - 2020 DA - 2020/12/31 TI - P.21 Albuminuria intensifies the relationship between urinary sodium excretion and central pulse pressure: the Wakuya study JO - Artery Research SP - S43 EP - S43 VL - 26 IS - Supplement 1 SN - 1876-4401 UR - https://doi.org/10.2991/artres.k.201209.034 DO - 10.2991/artres.k.201209.034 ID - Tagawa2020 ER -